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Immunosuppression

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Pancreas Transplantation

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Abstract

In clinical practice the recipient of a pancreatic organ graft requires treatment to modify the immune response so that the graft is able to survive within the host. This is usually achieved by the administration of nonspecific agents, which endeavor to create a compromise between the need for immunosuppression and the protection of the graft, and depleting the recipient’s own immune system such that overwhelming infection can occur. Agents such as steroids [1] and azathioprine [2] were the mainstay of clinical organ transplantation for over a decade and additional agents such as cyclosporine [3] and monoclonal antibodies [4] have only recently become available. Monoclonal antibodies themselves perhaps represent the first real attempt to be more selective in depletion of recipient target lymphocytes.

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Authors
  1. Paul McMaster
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Editors and Affiliations

  1. Department of Surgery, Mount Carmel Mercy Hospital, Detroit, Michigan, USA

    Luis H. Toledo-Pereyra M.D., Ph.D., Ph.D. (Chief, Transplantation, Director, Research) (Chief, Transplantation, Director, Research)

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© 1988 Kluwer Academic Publishers

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McMaster, P. (1988). Immunosuppression. In: Toledo-Pereyra, L.H. (eds) Pancreas Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1735-7_11

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  • DOI: https://doi.org/10.1007/978-1-4613-1735-7_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8976-0

  • Online ISBN: 978-1-4613-1735-7

  • eBook Packages: Springer Book Archive

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