Human mammary epithelial cells in culture: differentiation and transformation

  • Martha R. Stampfer
  • Jack C. Bartley
Part of the Cancer Treatment and Research book series (CTAR, volume 40)


The development of human mammary epithelial cell (HMEC) tissue culture systems has permitted these cells to be examined under controlled experimental conditions. Since recourse to in vivo studies is not possible with humans, the fidelity with which the culture system reflects the in vivo situation is particularly important, if the information obtained in vitro is to have meaning for understanding the normal and perturbed functions of the human breast. We describe here our results in developing a system for long term growth of human mammary epithelial cells in monolayer culture [1–4]. While this system is still far from providing an accurate representation of the many different stages of functional differentiation which may occur in the breast, it is a useful beginning to understand control of normal differentiated states, and to examine the multiple steps in the progression from normal to malignantly transformed cells.


Human Mammary Epithelial Cell Human Epithelial Cell Extended Lifespan Reduction Mammoplasty Human Breast Epithelial Cell 
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Copyright information

© Kluwer Academic Publishers, Boston/Dordrecht/London 1988

Authors and Affiliations

  • Martha R. Stampfer
  • Jack C. Bartley

There are no affiliations available

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