Flutamide and Other Antiandrogens in the Treatment of Advanced Prostatic Carcinoma

  • Pramod C. Sogani
  • Willet F. WhitmoreJr.
Part of the Cancer Treatment and Research book series (CTAR, volume 39)

Abstract

Prostatic cancer is the second most common malignancy in males and the third leading cause of cancer deaths in men in the United States. It is estimated that in 1987 there were 96,000 newly diagnosed cases and 27,000 deaths from prostatic cancer in the United States [1] Approximately 50% of men with prostatic cancer have advanced disease at the time of initial presentation. The realistic objective of treatment in these patients is palliation rather than cure. In 1941, Huggins and Hodges reported the results of their pioneering work, revealing that castration or additive estrogen therapy produced regression of prostatic cancer [2,3]. Although the majority of patients with advanced prostatic cancer can be palliated by either of these hormonal manipulations, the treatments are not without drawbacks. For example, castration is an invasive procedure, psychologically unacceptable to some patients, and estrogen therapy may be associated with fluid retention, thromboembolic complications, gynecomastia, and gastrointestinal side effects. Therefore, an effective systemic therapy readily acceptable to all patients and without side effects remains a desirable goal. Antiandrogens are one of several approaches that have been explored as alternatives to castration or estrogens in patients with advanced prostatic cancer.

Keywords

Estrogen Oncol Flare Estradiol Prolactin 

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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  • Pramod C. Sogani
  • Willet F. WhitmoreJr.

There are no affiliations available

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