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Preclinical Studies and Antitumor Mechanism of Action of LHRH Analogues

  • Chapter
Endocrine Therapies in Breast and Prostate Cancer

Part of the book series: Cancer Treatment and Research ((CTAR,volume 39))

Abstract

In the last 15 years a new class of pharmacologic agents has emerged—luteinizing hormone-releasing hormone (LHRH) analogues. As their name suggests, they are modified versions of LHRH and can either have agonistic or antagonistic properties. Because LHRH is essential for normal reproductive functions in mammals, it is not surprising that the availability of these drugs has generated much excitement, and they are currently under examination as clinical agents in such diverse areas as the augmentation of fertility [1], contraception [2], and oncology [3,4]. Our own interest in LHRH analogues began in 1977 following an approach by ICI Pharmaceuticals division in the United Kingdom to screen a series of LHRH agonists that they believed might have interesting endocrinologic and antitumor properties. The results obtained at that time clearly showed that in female rats the compounds were able to suppress ovarian activity, reduce circulating levels of estradiol, and cause a decrease in size of estrogen target tissue [5], including an ability to promote extensive regressions in estrogen receptor-positive, dimethylben-zanthracene-induced mammary tumours [6, 7]. Similarly, in male animals, LHRH agonists decreased circulating levels of testosterone and, at least in young animals, promoted an atrophy of the accessory sex organs [8–10].

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Authors
  1. Robert I. Nicholson
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  2. Kerry J. Walker
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Editors and Affiliations

  1. Department of Medicine, Division of Oncology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA

    C. Kent Osborne

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© 1988 Kluwer Academic Publishers, Boston

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Nicholson, R.I., Walker, K.J. (1988). Preclinical Studies and Antitumor Mechanism of Action of LHRH Analogues. In: Osborne, C.K. (eds) Endocrine Therapies in Breast and Prostate Cancer. Cancer Treatment and Research, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1731-9_1

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  • DOI: https://doi.org/10.1007/978-1-4613-1731-9_1

  • Publisher Name: Springer, Boston, MA

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