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Radiation — Induced Genetic Damage and the Prostaglandin System

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Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)

Abstract

Radiation is one of the sheet anchors of cancer therapy. More often than not radiation is used in combination with anticancer drugs and surgery in the management of cancer. The death of any cell can be observed if the dose of radiation to which it is exposed is sufficiently high. However, after low doses of radiation (precise values vary with the tissue) disturbances in cell proliferation can be observed which may include interference with mitosis and DNA synthesis. This can lead to the formation of cells with abnormal DNA, with qualitative and/ or quantitative abnormalities. These effects of radiation are seen mainly in the tissues undergoing continual renewal such as mucosa, bone marrow, gonads etc., and the spectrum of damage ranging from progressive hypoplesia to total atrophy, depending on the dose. One of the late effects of radiation is the development of cancer.

Keywords

Arachidonic Acid Free Radical Generation Bone Marrow Suppression Genetic Damage Genotoxic Action 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Department of Clinical Pharmacology and Medical ResearchNizam’s Institute of Medical SciencesPunjagutta, HyderabadIndia

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