Abstract
Radiation is one of the sheet anchors of cancer therapy. More often than not radiation is used in combination with anticancer drugs and surgery in the management of cancer. The death of any cell can be observed if the dose of radiation to which it is exposed is sufficiently high. However, after low doses of radiation (precise values vary with the tissue) disturbances in cell proliferation can be observed which may include interference with mitosis and DNA synthesis. This can lead to the formation of cells with abnormal DNA, with qualitative and/ or quantitative abnormalities. These effects of radiation are seen mainly in the tissues undergoing continual renewal such as mucosa, bone marrow, gonads etc., and the spectrum of damage ranging from progressive hypoplesia to total atrophy, depending on the dose. One of the late effects of radiation is the development of cancer.
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© 1988 Kluwer Academic Publishers, Boston
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Das, U.N., Devi, G.R. (1988). Radiation — Induced Genetic Damage and the Prostaglandin System. In: Polgar, P. (eds) Eicosanoids and Radiation. Prostaglandins, Leukotrienes, and Cancer, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1723-4_9
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DOI: https://doi.org/10.1007/978-1-4613-1723-4_9
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