Protection against Ionizing Radiation with Eicosanoids

Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)


Prostaglandins (PGs) are extremely diverse in their pharmacological activities. They exhibit both antagonistic as well as cytoprotective properties in the pathogenesis of inflammation. Participation of PGs as chemical mediators in the regulation of immune responses and inflammation are increasingly apparent (1–3). The antagonistic properties of PGs have been implicated in a variety of symptoms resulting from exposure to ionizing radiation. Post irradiation increases in small bowel motility (4), diarrhea, flatulence, abdominal pain (5), mucositis (6), and esophagitis (7,8) have been attributed, in part, to excessive PG production.


Essential Fatty Acid Radiation Injury Essential Fatty Acid Deficiency Intestinal Stem Cell Increase Cell Survival 
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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Department of Radiation Biochemistry and Chair of ScienceArmed Forces Radiobiology Research InstituteBethesdaUSA

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