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Irradiation and Blood Vessel Prostaglandin Metabolism

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Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)

Abstract

Nowadays, it is well known, that tissue damage is associated with thrombosis of vessels in irradiated areas. As early as in 1944 Sheehan (43) was the first relating the foam cell plaque formation to an effect of irradiation. Warren (61) reported in 1942 atherosclerosis-like lesions. Later on, a number of experimental studies have been performed in order to elucidate the pathomechanism of irradiation- induced vasculopathy showing in rat (2), chicken (58) and swine (30) that irradiation accelerates the development of atherosclerosis. Endothelial damage (9, 10, 25, 27, 28, 29, 57), increased vascularwallpermeability(35), enhanced mitotic activity (14, 44, 46) and parietal thrombus formation (6, 15, 16) have been shown to be early mechanisms involved. Human data provide evidence for cerebrovascular consequences (7) and the development of coronary heart disease induced by irradiation (5, 38). Although all these mechanisms together with the finding, that aspirin reduces the severity of radiation-induced vascular lesions (56) indicate, that the prostaglandin (PG)-system is involved to an important extent too, there is only limited information available so far concerning the importance of the PG-systemin the blood-vessel wall interaction during and after irradiation.

Keywords

Cervical Cancer Arachidonic Acid Aggregation Response Control Segment Serum TXB2 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Dept. of Nuclear Medicine, Atherosclerosis Research Group (ASF), 1st Dept. of Gynecology and Obstetrics(R.R.)University of ViennaVienna(H.S.)Austria

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