Effects of Gamma Irradiation on Prostaglandin Biosynthesis and Metabolism: Intact Tissues

Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)


Exposure to gamma irradiation can affect the synthesis and metabolism of potent biochemical agents within various organs, tissues, and cell types, resulting in a wide range of effects (1,2), potentially either harmful or protective. Ionizing radiation has been shown to produce changes in prostaglandin production by a variety of tissues (3,4); however the precise mechanisms of such alterations and the role of prostaglandins in the patho-physiological effects of ionizing radiation have not been fully elucidated.


Gamma Irradiation Mefenamic Acid Intact Tissue Prostaglandin Production Prostaglandin Biosynthesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Altman KI, Gerber GB, Okada S: Radiation Biochemistry, Vol II:Tissues and body fluids. Academic Press, New York, 1970Google Scholar
  2. 2.
    Berdjis CC: Pathology of Irradiation. Williams and Wilkins, Baltimore, 1971Google Scholar
  3. 3.
    Eisen V and Walker DI: Br J Pharmac 57:527–532, 1976Google Scholar
  4. 4.
    Eisen V, Walker DI, Binysh SG, Tedder RS: Agents and Actions, Suppl 2:99–103, 1977Google Scholar
  5. 5.
    Hahn GL, Menconi M J, Polgar P: In: Prostaglandins and Cancer (eds. TJ Powles, RS Bockman, KV Honn, P Ramwell) Alan R. Liss, New York, 1981, pp. 381–384Google Scholar
  6. 6.
    Hahn GL, Menconi MJ, Cahill M, and Polgar P: Prostaglandins 25:783–791, 1983PubMedCrossRefGoogle Scholar
  7. 7.
    Rubin P, Casarett GW: In: Clinical Radiation Pathology, Vol 1 (eds. P Rubin, GW Casarett) W. B. Saunders, Philadelphia 1968, pp. 38–61Google Scholar
  8. 8.
    Dunsmore LD, LoPonte MA, Dunsmore RA: J Am Coll Cardiol 8:239–244, 1986PubMedCrossRefGoogle Scholar
  9. 9.
    Eldor A, Vlodavsky I, HyAm E, Atzmon R, Fuks Z: Prostaglandins 25:263–279, 1983PubMedCrossRefGoogle Scholar
  10. 10.
    Allen JB, Sagerman RH, Stuart MJ: Lancet 2:1193–1196, 1981PubMedCrossRefGoogle Scholar
  11. 11.
    Sinzinger H, Firbas W, Cromwell M: Prostaglandins 24:323–329, 1982PubMedCrossRefGoogle Scholar
  12. 12.
    Steel LK and Catravas GN: Int J Radiat Biol 42:517–530, 1982CrossRefGoogle Scholar
  13. 13.
    Heinz TR, Schneidkraut MJ, Kot PA, Ramwell PW, Rose JC: Prog Biochem Pharmacol 20:74–83, 1985PubMedGoogle Scholar
  14. 14.
    Haymaker W, Ibrahim MZM, Miguel J, Cell N, Riopelle AJ: J Neuropathol Exp Neurol 17:50–79, 1958Google Scholar
  15. 15.
    Rubenstein LJ, Herman MM, Long TF, Wilbur JR: Cancer 35:291–305, 1975CrossRefGoogle Scholar
  16. 16.
    Price RA, Birdwell DA: Cancer 42:717–728, 1978PubMedCrossRefGoogle Scholar
  17. 17.
    Pausescu E, Chirvasie R, Teodosiu T, Paun C: Rad Res 65:163–171, 1976CrossRefGoogle Scholar
  18. 18.
    Trocha PJ and Catravas GN: Int J Radiat Biol 38:503–511, 1980CrossRefGoogle Scholar
  19. 19.
    Trocha PJ and Catravas GN: In: Advances in Prostaglandin and Thromboxane Research, Vol. 7 (eds. B Samuelsson, PW Ramwell, and R Paoletti), Raven Press, New York, 1980, pp. 851–855Google Scholar
  20. 20.
    Tanner NSB, Stamford IF, Bennet A: Br J Cancer 43: 767–771, 1981PubMedCrossRefGoogle Scholar
  21. 21.
    Northway MG, Libshitz HI, Osborne BM, Feldman MS, Mamel JJ, West JH, Szwarc ILA: Gastroenterology 78:883–892, 1980PubMedGoogle Scholar
  22. 22.
    Borowska A, Sierakowski S, Mackowiak J, Wisniewski K: Experientia 35:1368–1370, 1979PubMedCrossRefGoogle Scholar
  23. 23.
    Gal D, Strickland DM, Lifshitz S, Buchsbaum HJ, Mitchell MD: Int J Rad Biol Oncol Phys 10:653–657, 1984CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Division of Maternal & Child HealthWilford Hall USAF Medical CenterSan AntonioUSA
  2. 2.Department of Reproductive MedicineUniversity of California-San DiegoLa JollaUSA

Personalised recommendations