Dermal Damage from Ultraviolet Radiation

Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)


Ultraviolet (UV) radiation is increasingly recognized as the cause of a vast number of changes in the skin of humans and animals. These include alterations at the molecular, cellular, tissue and systemic levels. In the recent past, much has been learned about the immediate effects in skin of acute UV exposure (i.e. sunburn) with its epidermal cell death, inflammation and vasodilation (1,2). With chronic exposure, many of the clinical and histologic effects can be seen only after decades. Visually, these are hyper-and hypopigmented macules, dry scaly, wrinkled skin with a variety of benign, pre-malignant and malignant neoplasms. All epidermal in origin, they lead, inexorably in humans, to the appearance we described as photo-aged (3). Underlying many of these visible manifestations are drastic changes in the dermis. These relate chiefly to destruction of mature collagen, with a compensatory overproduction of reticulin fibers, hyperplasia of elastic fibers eventuating in elastosis, increased levels of the glycosaminoglycans (GAGs) comprising the ground substance and changes in the microvasculature. First described in actinically damaged humans (4,5), systematic investigation required an animal model.


Elastic Fiber Ground Substance Hairless Mouse Irradiate Animal Black Light 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Gilchrest, B.A., Soter, N.A., Stoff, J.S. and Mihm, M.C. Jr. J. Amer. Acad. Dermatol. 5:411–422, 1981.CrossRefGoogle Scholar
  2. 2.
    Kaidbey, K.H. and Kligman, A.M. J. Invest. Dermatol. 72:253–256, 1979.PubMedCrossRefGoogle Scholar
  3. 3.
    Kligman, L.H. In: Dermatology Clinics. Aging Skin (Ed. B.A. Gilchrest), W.B. Saunders Co. Vol. 4, Philadelphia, 1986, pp.517–528.Google Scholar
  4. 4.
    Sams, W.M. Jr. and Smith, J.G. Jr. J. Invest. Dermatol. 37:447–452, 1961.PubMedCrossRefGoogle Scholar
  5. 5.
    Kligman, A.M. J. Amer. Med. Assoc. 210:2377–2380, 1969.CrossRefGoogle Scholar
  6. 6.
    Sams, W.M. Jr., Smith, J.G. Jr. and Burk, P.G. J. Invest. Dermatol. 43:467–471, 1964.PubMedGoogle Scholar
  7. 7.
    Cole, CA., Davies, R.E., Forbes, P.D. and D’Aloisio, L.C. Photo-chem. Photobiol. 217:623–631, 1983.CrossRefGoogle Scholar
  8. 8.
    Kligman, L.H. and Kligman, A.M. J. Nat. Cancer Inst. 67:1289–1297, 1981.PubMedGoogle Scholar
  9. 9.
    Kligman, L.H., Akin, F.J. and Kligman, A.M. J. Invest. Dermatol. 78:181–189, 1982.PubMedCrossRefGoogle Scholar
  10. 10.
    Kligman, L.H., Akin, F.J. and Kligman, A.M. J. Invest. Dermatol. 81:98–102, 1983.PubMedCrossRefGoogle Scholar
  11. 11.
    Kligman, L.H., Akin, F.J. and Kligman, A.M. J. Invest. Dermatol. 84:272–276, 1985.PubMedCrossRefGoogle Scholar
  12. 12.
    Kligman, L.H. Amer. J. Dermatopath. 3:199–200, 1981.CrossRefGoogle Scholar
  13. 13.
    Kajikawa, K., Yamaguchi, T., Katsuda, S. and Miwa, A. J. Electron Micro. 24:287–289, 1975.Google Scholar
  14. 14.
    Hirose, R. and Kligman, L.H. J. Invest. Dermatol. 86:481, 1986.Google Scholar
  15. 15.
    Braverman, I.M. and Fonferko, E. J. Invest. Dermatol. 78:434–443, 1982.CrossRefGoogle Scholar
  16. 16.
    Gilchrest, B.A., Soter, N.A., Hawk, J.L.M., Barr, R.M., Black, A.K., Hensby, C.N., Mallet, A.I., Greaves, M.W. and Parrish, J.A. J. Amer. Acad. Dermatol. 9:213–219, 1983.CrossRefGoogle Scholar
  17. 17.
    Johnston, K.J., Oikarinen, A.I., Lowe, N.J., Clark, J.G. and Uitto, J. J. Invest. Dermatol. 82:587–590, 1984.CrossRefGoogle Scholar
  18. 18.
    Berger, H., Tsambaos, D. and Kaase, H. Z. Hautkr. 55:1510–1527, 1980.PubMedGoogle Scholar
  19. 19.
    Sakura, S., Fujimoto, D., Sakamoto, K., Mizuno, A. and Motegi, K. Can. J. Biochem. 60:525–529, 1982.PubMedCrossRefGoogle Scholar
  20. 20.
    Lovell, W.W. Trans. St. Johns Hosp. Dermatol. Soc. 59:166–174, 1973.PubMedGoogle Scholar
  21. 21.
    Werb, Z., Banda, M.J. and Jones, P.A. J. Exp. Med. 152:1340–1357, 1980.PubMedCrossRefGoogle Scholar
  22. 22.
    Mainardi, C.L., Hasty, D.L., Seyer, J.M. and Kang, A.H. J. Biol. Chem. 255:12006–12010, 1980.PubMedGoogle Scholar
  23. 23.
    Baugh, R.J. and Travis, J. Biochem. 15:836–841, 1976.CrossRefGoogle Scholar
  24. 24.
    Camp, R.D., Greaves, M.W., Hensby, C.N., Plummer, N.A. and Warin, A.P. Br. J. Clin. Pharmacol. 6:145–148, 1978.PubMedGoogle Scholar
  25. 25.
    Black, A.K., Fincham, N., Greaves, M.W. and Hensby, C.N. Br. J. Clin. Pharmacol. 10:453–457, 1980.PubMedGoogle Scholar
  26. 26.
    Hawk, J.L.M., Black, A.K., Jaenicke, K.F., Barr, R.M., Soter, N.A., Mallett, A.I., Gilchrest, B.A., Hensby, C.N., Parrish, J.A. and Greaves, M.W. J. Invest. Dermatol. 80:496–499, 1983.PubMedCrossRefGoogle Scholar
  27. 27.
    Ruzicka, T., Walters, J.F. and Printz, M.P. J. Invest. Dermatol. 81:300–303, 1983.PubMedCrossRefGoogle Scholar
  28. 28.
    Burrall, B. and Ziboh, V.A. J. Invest. Dermatol. 86:643–648, 1986.PubMedCrossRefGoogle Scholar
  29. 29.
    DeLeo, V.A., Hanson, D., Weinstein, LB. and Harber, L.C. Photo-chem. Photobiol. 41:51–56, 1985.CrossRefGoogle Scholar
  30. 30.
    DeLeo, V.A., Miller, S., Chew, S. and Scheide, S. Photochem. Photobiol. 43s:92, 1986.Google Scholar
  31. 31.
    Kragballe, K. and Voorhees, J.J. J. Invest. Dermatol. 81:293–296, 1983.PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Department of DermatologyThe University of Pennsylvania School of MedicinePhiladelphiaUSA

Personalised recommendations