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Radiation, Lipid Peroxidation and the Role of Oxygen Radicals in Eicosanoid Metabolism

Chapter
Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)

Abstract

Exposure to ultraviolet or ionizing radiation can initiate the production and/or release of potent metabolites within specific organs, tissues or cell types, resulting in a wide range of effects. One class of biologically active agents whose production is affected by radiation is the eicosanoids. The biosynthesis of eicosanoids from their fatty acid precursors can be stimulated by either specific cell surface membrane receptors or general cell injury. Numerous studies have demonstrated that radiation alters the biosynthesis of prostaglandins (PGs) in a wide variety of tissues, including the lung, spleen, liver, skin and vasculature. While the precise role of PGs in the biological response to radiation is not fully understood, these alterations may be related to subsequent normal as well as pathophysiological responses.

Keywords

Lipid Peroxidation Platelet Activate Factor Lecithin Liposome Fluorescence Polarization Measurement Cellular Peroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Department of BiochemistryBoston University School of MedicineBostonUSA

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