Radiation, Lipid Peroxidation and the Role of Oxygen Radicals in Eicosanoid Metabolism

Part of the Prostaglandins, Leukotrienes, and Cancer book series (PLAC, volume 5)


Exposure to ultraviolet or ionizing radiation can initiate the production and/or release of potent metabolites within specific organs, tissues or cell types, resulting in a wide range of effects. One class of biologically active agents whose production is affected by radiation is the eicosanoids. The biosynthesis of eicosanoids from their fatty acid precursors can be stimulated by either specific cell surface membrane receptors or general cell injury. Numerous studies have demonstrated that radiation alters the biosynthesis of prostaglandins (PGs) in a wide variety of tissues, including the lung, spleen, liver, skin and vasculature. While the precise role of PGs in the biological response to radiation is not fully understood, these alterations may be related to subsequent normal as well as pathophysiological responses.


Lipid Peroxidation Platelet Activate Factor Lecithin Liposome Fluorescence Polarization Measurement Cellular Peroxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Edwards, J.C., Chapman, D., Cramp, W.A. and Yatvin, M.B. Progr. Biophys. Mol. Biol. 43:71–93, 1984.CrossRefGoogle Scholar
  2. 2.
    Anbar, M. and Neta, P. Int. J. Appl. Radiat. Isot. 18:493–523, 1967.CrossRefGoogle Scholar
  3. 3.
    Petkau, A. Can. J. Chem. 49:1187–1195, 1971.CrossRefGoogle Scholar
  4. 4.
    Petkau, A. and Chelack, W.S. Int. J. Radiat. Biol. 25:321–328, 1974.CrossRefGoogle Scholar
  5. 5.
    Petkau, A. and Chelack, W.S. Int. J. Radiat. Biol. 26:421–426, 1974.CrossRefGoogle Scholar
  6. 6.
    Behar, D., Czapski, G., Dorfman, L.M., Rabani, J. and Schwarz, H.A.J. Phys. Chem. 74:3209–3213, 1970.CrossRefGoogle Scholar
  7. 7.
    Klug, D., Rabani, J. and Fridovich, I. J. Biol. Chem. 247:4839–4842, 1972.PubMedGoogle Scholar
  8. 8.
    Goda, K., Kimura, T., Thayer, A.L., Kees, K. and Schaap, A.P. Biochem. Biophys. Res. Commun. 58:660–666, 1974.PubMedCrossRefGoogle Scholar
  9. 9.
    Rawls, H.R. and Van Santen, P.J. J. Am. Oil Chem. Soc. 47:121–125, 1970.CrossRefGoogle Scholar
  10. 10.
    Rawls, H.R. and Van Santen, P.J. Ann. N.Y. Acad. Sci. 171:135–137, 1970.CrossRefGoogle Scholar
  11. 11.
    Halliwell, B. New Phytol. 73:1075–1086, 1974.CrossRefGoogle Scholar
  12. 12.
    McCord, J.M. and Fridovich, I. J. Biol. Chem. 244:6049–6055, 1969.PubMedGoogle Scholar
  13. 13.
    Pederson, T.C. and Aust, S.D. Biochem. Biophys. Res. Commun. 52:1071–1078, 1973.PubMedCrossRefGoogle Scholar
  14. 14.
    Debey, P. and Balny, C. Biochimie 55:329–332, 1973.PubMedCrossRefGoogle Scholar
  15. 15.
    Tyler, D.D. Febs Lett. 51:180–183, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    Petkau, A. and Chelack, W.S. Biochim. Biophys. Acta 433:445–456, 1976.PubMedCrossRefGoogle Scholar
  17. 17.
    Inouye, B., Aono, K., Iida, S. and Utsumi, K. Physiol. Chem. & Physics 11:151–160, 1979.Google Scholar
  18. 18.
    Haber, F. and Weiss, J. Proc. R. Soc. Ser. A. 147:332–351, 1934.CrossRefGoogle Scholar
  19. 19.
    Singh, A. and Singh, H. Prog. Biophys. Molec. Biol. 39:69–107, 1982.CrossRefGoogle Scholar
  20. 20.
    Leyko, W. and Bartosz, G. Int. J. Radiat. Biol. 49:743–770, 1986.CrossRefGoogle Scholar
  21. 21.
    Myers, D.K. In: Advances in Biological and Medical Physics (Eds. J.H. Lawrence and J.W. Gofman), Academic Press, New York, 1970, Vol. 13, pp. 219–234.Google Scholar
  22. 22.
    Wilbur, K.M., Bernhein, F. and Shapiro, O.W. Arch. Biochem 24:305–313, 1949.PubMedGoogle Scholar
  23. 23.
    Ingold, K.U. Chem. Rev. 61:563–589, 1961.CrossRefGoogle Scholar
  24. 24.
    Dahle, L.K., Hill, E.G. and Holman, R.T. Arch. Biochem. Biophys. 98:253–261, 1962.PubMedCrossRefGoogle Scholar
  25. 25.
    Pryor, W.A. Fed. Proc. 32:1862–1869, 1973.PubMedGoogle Scholar
  26. 26.
    Nakazawa, T., Nagatsuka, S. and Sakurai, T. Int. J. Radiat. Biol. 40:365–373, 1981.CrossRefGoogle Scholar
  27. 27.
    Mooibroek, J., Trieling, W.B. and Konings, A.W.T. Int. J. Radiat. Biol. 42:601–609, 1982.CrossRefGoogle Scholar
  28. 28.
    O’Connell, M.J. and Garner, A. Int. J. Radiat. Biol. 44:615–625, 1983.CrossRefGoogle Scholar
  29. 29.
    Konings, A.W.T. Int. J. Radiat. Biol. 40:441–444, 1981.CrossRefGoogle Scholar
  30. 30.
    Konings, A.W.T., Damen, J. and Trieling, W.B. Int. J. Radiat. Biol. 35:343–350, 1979.CrossRefGoogle Scholar
  31. 31.
    Wills, E.D. and Wilkinson, A.E. Radiat. Res. 31:732–747, 1967.CrossRefGoogle Scholar
  32. 32.
    Barber, D.J.W. and Thomas, J.K. Radiat. Res. 74:51–65, 1978.CrossRefGoogle Scholar
  33. 33.
    Purohit, S.C., Bisby, R.H. and Cundall, R.B. Int. J. Radiat. Biol. 38:C147–158, 1980.CrossRefGoogle Scholar
  34. 34.
    Purohit, S.C., Bisby, R.H. and Cundall, R.B. Int. J. Radiat. Biol. 38:159–166, 1980.CrossRefGoogle Scholar
  35. 35.
    Nakazawa, T., Nagatsuka, S. Int. J. Radiat. Biol. 38:537–544, 1980.CrossRefGoogle Scholar
  36. 36.
    Cataldi de Flombaum, M.A. and Stoppani, A.O.M. Biochem. International 12:785–793, 1986.Google Scholar
  37. 37.
    Das, D.K. and Neogi, A. Clin. Physiol. Biochem. 2:32–38, 1984.PubMedGoogle Scholar
  38. 38.
    Burkhardt, H., Scwingel, M., Menninger, H., McCartney, H.W. and Tschesche, H. Arthritis and Rheumatism 29:379–387, 1986.PubMedCrossRefGoogle Scholar
  39. 39.
    Ortiz, X., Ragsdale, C. and Test, S.T. Science 227:747–749, 1985.PubMedCrossRefGoogle Scholar
  40. 40.
    Wills, E.D. Biochem. J. 123:983–991, 1971.PubMedGoogle Scholar
  41. 41.
    Kamataki, T. and Kitagawa, H. Biochem. Pharmacol. 22:3199–3207, 1973.PubMedCrossRefGoogle Scholar
  42. 42.
    Koster, J.F. and Slee, R.G. Biochem. Biophys. Acta 620:489–499, 1980.PubMedGoogle Scholar
  43. 43.
    Wills, E.D. and Wilkinson, A.E. Int. J. Radiat. Biol. 17:229–236, 1970.CrossRefGoogle Scholar
  44. 44.
    Yukawa, O. and Nakazawa, T. Int. J. Radiat. Biol. 37:621–631, 1980.Google Scholar
  45. 45.
    Yukawa, O., Nagatsuka, S. and Nakazawa, T. Int. J. Radiat. Biol. 43:391–398, 1983.CrossRefGoogle Scholar
  46. 46.
    Hemler, M. and Lands, W.E.M. J. Biol. Chem. 251:5575–5579, 1976.PubMedGoogle Scholar
  47. 47.
    Van der Ouderaa, F.J., Buytenhek, F.J., Nugteren, D.H. and Van Dorp, D.A. Biochim. Biophys. Acta 487:315–331, 1977.PubMedGoogle Scholar
  48. 48.
    Hamberg, M. and Samuelsson, B. Biochem. Biophys. Res. Commun. 61:942–949, 1974.PubMedCrossRefGoogle Scholar
  49. 49.
    Hamberg, M. and Samuelsson, B. Proc. Natl. Acad. Sci. (USA) 71:3400–3404, 1974.CrossRefGoogle Scholar
  50. 50.
    Nugteren, D.H. and Hazelhof, E. Biochim. Biophys. Acta 326:448–461, 1973.PubMedGoogle Scholar
  51. 51.
    Egan, R.W., Paxton, J. and Kuehl, F.A., Jr. J. Biol. Chem. 251:7329–7335, 1976.PubMedGoogle Scholar
  52. 52.
    Egan, R.W., Gale, P.H. and Kuehl, F.A., Jr. J. Biol. Chem. 254:3295–3302, 1979.PubMedGoogle Scholar
  53. 53.
    Miyamoto, T., Oginn, N., Yamamoto, S. and Hayaishi, O. J. Biol. Chem. 251:2629–2636, 1976.PubMedGoogle Scholar
  54. 54.
    Smith, W.L. and Lands, W.E.M. Biochem. 11:3276–3285, 1972.CrossRefGoogle Scholar
  55. 55.
    Ham, E.A., Egan, R.W. Soderman, D.D., Gale, P.H. and Kuehl, F.A., Jr. J. Biol. Chem. 254:2191–2194, 1979.PubMedGoogle Scholar
  56. 56.
    Hemler, M.E., Lands, W.E.M. and Graff, G. Biochem. Biophys. Res. Commun. 85:1325–1331, 1978.PubMedCrossRefGoogle Scholar
  57. 57.
    Hemler, M.E., Cook, H.W. and Lands, W.E.M. Arch. Biochem. Biophys. 193:340–345, 1979.PubMedCrossRefGoogle Scholar
  58. 58.
    Panganamala, R.V., Sharma, H.M., Sprecher, H., Greer, J.C. and Cornwell, D.G. Prostglandins 8:3–11, 1974.CrossRefGoogle Scholar
  59. 59.
    Morse, D.E., Duncan, H., Hooker, N. and Morse, A. Science 196:298–300, 1977.PubMedCrossRefGoogle Scholar
  60. 60.
    Polgar, P. and Taylor, L. Prostaglandins 19:693–700, 1980.PubMedCrossRefGoogle Scholar
  61. 61.
    Taylor, L., Menconi, M., Leibowitz, H. and Polgar, P. Invest. Opthalmol. & Vis. Sci. 23:378–382, 1982.Google Scholar
  62. 62.
    Taylor, L., Menconi, M.J. and Polgar, P. J. Biol. Chem. 258:6855–6857, 1983.Google Scholar
  63. 63.
    Hemler, M. E. and Lands, W.E.M. J. Biol. Chem. 255:6253–6261, 1980.PubMedGoogle Scholar
  64. 64.
    Fujimoto, Y, Tanioka, H., Keshi, I. and Fujita, T. Biochem. J. 212:167–171, 1983.PubMedGoogle Scholar
  65. 65.
    Deby, C. and Deby-Dupont, G. In:Biological and Clinical Aspects of Superoxide and Superoxide Dismutase (Eds. W.H. Bannister and J.V. Bannister), Proc. Fed. Eur. Biochem. Soc. Symposium No. 62, 1982, pp. 84–97.Google Scholar
  66. 66.
    Donlon, J., Steel, L., Helgeson, E.A., Wolfe, W.W. and Catravas, G.N. Int. J. Radiat. Biol. 47:205–212, 1985.CrossRefGoogle Scholar
  67. 67.
    Fowler, J.F. Int. J. Radiat. Oncol. Biol. Phys. 11:665–674, 1985.PubMedCrossRefGoogle Scholar
  68. 68.
    Menconi, M., Taylor, L. and Polgar, P. In:Prostaglandin and Lipid Metabolism in Radiation Injury (Eds. T.L. Waiden, Jr. and H.N. Hughes), 1987, in press.Google Scholar
  69. 69.
    Friedman, M., Saunders, D.S., Madden, M.C., Chaney, E.L. and Kwock, L. Radiat. Res. 106:171–181, 1986.PubMedCrossRefGoogle Scholar
  70. 70.
    Hahn, G.L., Menconi, M.J., Cahill, M. and Polgar, P. Prostaglandins 25:783–791, 1983.PubMedCrossRefGoogle Scholar
  71. 71.
    Camussi, G., Aglietta, M., Malavasi, F., Tetta, C, Piacibello, W., Sanavio, F. and Bussolino, F. J. Immunol. 131:2397–2403, 1983.PubMedGoogle Scholar
  72. 72.
    Prescott, S.M., Zimmerman, G.A. and McIntyre, T.M. Proc. Natl. Acad. Sci. (USA) 81:3534–3538, 1984.CrossRefGoogle Scholar
  73. 74.
    Fujimoto, Y. and Fujita, T. Biochim. Biophys. Acta 710:82–86, 1982.PubMedGoogle Scholar
  74. 75.
    Ogawa, Y., Kondo, T., Sugiyama, S., Ogawa, K., Satake, T. and Ozawa, T. Cancer Res. 47:1239–1243, 1987.PubMedGoogle Scholar
  75. 76.
    Hong, K., Meyer, D.J., Belin, J. and Ketterer, B. Biochem. J. 220:243–252, 1984.Google Scholar
  76. 77.
    Sevanian, A., Muakkassah-Kelly, S.F. and Montestruque, S. Archiv. Biochim. Biophys. 441–452, 1983.Google Scholar
  77. 78.
    Shewfelt, R. and Hultin, H.O. Biochim. Biophys. Acta 751:432–438, 1983.PubMedGoogle Scholar
  78. 79.
    Grossmann, A. and Wendel, A. European J. Biochem. 135:549–552, 1983.CrossRefGoogle Scholar
  79. 80.
    Ziboh, V.A., Lord, J.T., Uematsu, S. and Blick, G. J. Invest. Dermatol. 70:211, 1978.CrossRefGoogle Scholar
  80. 81.
    Lord, J.T., Ziboh, V.A., Poitier, J., Legget, G. and Penneys, N.S. Br. J. Dermatol. 95:397–406, 1976.PubMedCrossRefGoogle Scholar
  81. 82.
    Orlov, S.N., Malkov, Y.A., Rebrov, V.G. and Danilov, V.S. Biophysics (USSR) 21:278–282, 1976.Google Scholar
  82. 83.
    Pathak, M.A. and Stratton, K. Arch. Biochem. Biophys. 123:468–476, 1968.PubMedCrossRefGoogle Scholar
  83. 84.
    Meffert, H., Diezel, W. and Sonnichsen, N. Experientia 32:1397–1398, 1976.PubMedCrossRefGoogle Scholar
  84. 85.
    Mandai, T.K. and Chatterjee, S.N. Radiat. Res. 83:290–302, 1980.CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers, Boston 1988

Authors and Affiliations

  1. 1.Department of BiochemistryBoston University School of MedicineBostonUSA

Personalised recommendations