Role of Nerve Growth Factor in the Central Nervous System

  • Franz Hefti
  • Jukka A. Hartikka
  • Claudia N. Montero
  • Emmanuel O. Junard
Part of the Topics in the Neurosciences book series (TINS, volume 8)


In recent years, the concept has evolved that survival of neurons during development is influenced by “neurotrophic factors.” Paradigmatic studies were those on nerve growth factor (NGF), which affects survival and function of peripheral sympathetic and sensory neurons [1–4]. Other neurotrophic factors have been characterized that affect the survival and function of parasympathetic neurons [5], of cholinergic motorneurons [6], of retinal cells, and of a subpopulation of sensory neurons [7, 8]. These findings have been taken to suggest that populations of neurons require the presence of specific neurotrophic factors for survival during development, during differentiation, and for maintenance of function [9, 10].


Nerve Growth Factor Cholinergic Neuron Basal Forebrain Nucleus Basalis Choline Acetyltransferase 
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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Franz Hefti
  • Jukka A. Hartikka
  • Claudia N. Montero
  • Emmanuel O. Junard

There are no affiliations available

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