Abstract
Studies of naturally-occurring neuronal death have tended to emphasize almost exclusively the role of neuron-target interactions in the competitive events that result in the survival of a proportion of a pre-cell death population of neurons and the degeneration and death of the remainder. The reason for this restricted focus on targets, of course, is that a large number of studies examining different types of neurons in a variety of species have shown that increases or decreases in the size, volume, number, or type of targets is associated with increased or decreased survival of those neurons that innervate the altered targets [1, 2]. Consequently, there is a consensus among workers in this field that for many populations of neurons, targets are exceedingly important for regulating how many neurons will survive the cell death period. However, there is also a growing recognition that afferent influences may be involved in regulating cell death [3–5]. Ideally, in order to critically examine the relative contributions of afferent and target influences on neuronal survival and death, it would be advantageous to focus on a neuronal population that receives a single source of afferent input and projects to a single target region and in which the afferent and target cells can be independently and systematically perturbed at developmental stages prior to the onset of naturally-occurring cell death. The ciliary ganglion of the chick embryo is one of the few neuronal populations that meets these criteria.
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Supported by NIH grant NS 20402.
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Oppenheim, R.W. (1988). Evidence for the Role of Afferents in the Regulation of Neuronal Survival during Normal Periods of Developmental Cell Death: Motoneurons and the Ciliary Ganglion. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_6
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