Abstract
Excitatory amino acid receptors have been classified into four major subclasses characterized by their high affinity binding specificity for N-methyl-D-aspartate (NMDA), quisqualate, kainate, and 2-amino-4-phosphonobutyrate (APB), none of which are the endogenous ligands for their recognition sites. This classification is based on the results of electrophysiological and radioligand binding studies [1–5], which are insufficient to express the complete profile of the transmitter receptor function. Transmitter receptor function includes the transduction of an extraneuronal chemical signal into the stimulation of intraneuronal biochemical mechanisms, leading to a change of neuronal function of variable time course. This transduction occurs at synapses and involves the activation of specific enzymes located in the membrane of the postsynaptic cells that are part of a complex receptorial system including a recognition site for the chemical signal, a coupling unit, and a catalytic unit for the production of the intracellular second messenger. Often, instead of generating a second messenger, the receptor activation gates specific ion channels. This generates ion currents that can now be recorded with patch clamp techniques. The intracellular changes induced by these ion fluxes often last longer than the detectable changes in membrane conductance associated with the activation of specific ion channels.
Keywords
- Granule Cell
- Excitatory Amino Acid
- Cerebellar Granule Cell
- Allosteric Modulation
- Excitatory Amino Acid Receptor
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Costa, E., Fadda, E., Kozikowski, A.P., Nicoletti, F., Wroblewski, J.T. (1988). Classification and Allosteric Modulation of Excitatory Amino Acid Signal Transduction in Brain Slices and Primary Cultures of Cerebellar Neurons. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_3
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