Abstract
Cholecystokinin (CCK) was originally isolated from the intestine and was later discovered to be widely distributed in gut endocrine tissue and the central and peripheral nervous systems. Numerous studies have concluded that CCK displays many properties of a neurotransmitter or neuromodulator [1]. CCK is very abundant in the caudato-putamen (cp) of the rat, where it appears to be mainly extrinsic. In the rat, some dopamine neurons in the substantia nigra also contain CCK [2], These neurons are known to be, at best, a minor source of CCK for the cp [3, 4]. The precise CCK cell groups projecting to the cp have not been conclusively identified, but it appears that the claustrumpiriform cortex area or the amygdala are likely sites for these CCK perikarya [3, 4].
Keywords
- Excitatory Amino Acid
- Vasoactive Intestinal Polypeptide
- Excitatory Amino Acid Receptor
- Inhibitory Amino Acid
- Modulate Ligand Binding
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This work was supported in part by NIH grants NS 18667 and RS 05388 to St. Louis University.
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© 1988 Kluwer Academic Publishers
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Stone, J.M., Allard, L.R., Han, S.P., Beinfeld, M.C. (1988). Cholecystokinin Release from Rat Caudatoputamen Slices Incubated in Vitro is Inhibited by Excitatory Amino Acids. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_25
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DOI: https://doi.org/10.1007/978-1-4613-1721-0_25
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