Abstract
Two types of nonselective acidic amino acid antagonists have been reported to block non-NMDA receptors more potently than NMDA receptors in the spinal cord. These are y-glutamyl-aminomethylsulfonate (GAMS) [1] and the N-(p-chlorobenzoyl) and N-(p-bromobenzoyl) derivatives of piperazine-2,3-dicarboxylate (pCB-PzDA and pBB-PzDA, respectively) [2]. Recently, the effects of the piperazine dicarboxylate derivatives have been evaluated in the hippocampal slice. In contrast to the spinal cord, these compounds were shown to more effectively block NMDA responses than responses induced by kainate or quisqualate [3].
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© 1988 Kluwer Academic Publishers
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Rader, R.K., Lanthorn, T.H. (1988). Antagonist Effects of Y-Glutamyl-Aminomethylsulfonate in the in Vitro Hippocampal Slice. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_21
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DOI: https://doi.org/10.1007/978-1-4613-1721-0_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8969-2
Online ISBN: 978-1-4613-1721-0
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