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Role of Atriopeptin in Central Cardiovascular Control

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Neurobiology of Amino Acids, Peptides and Trophic Factors

Part of the book series: Topics in the Neurosciences ((TINS,volume 8))

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Abstract

Atriopeptin (AP), the atrial natriuretic peptide, is a 28 amino acid hormone that is synthesized in the atria of mammalian hearts [1]. During atrial stretch, AP is released into the circulation, where it binds to receptors in the renal glomeruli and papilla, resulting in profound natriuresis and diuresis (for review see Refs. 2–6). AP also binds to the adrenal glomerulosa, inhibiting the secretion of aldosterone, and to vascular smooth muscle, causing vasodilatation. AP, therefore, acts as a counterregulatory hormone to reduce blood volume and blood pressure, particularly during right atrial volume overload.

The work described in this communication was supported by NINCDS grant NS22835, NIGMS grants GM07200 and GM07895, American Heart Association grant-in-aid 850894, the Washington University-Monsanto Grant, and a grant from the Brain Research Foundation.

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Authors
  1. Clifford B. Saper
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  2. David G. Standaert
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Editors and Affiliations

  1. Washington University School of Medicine, USA

    James A. Ferrendelli , Robert C. Collins  & Eugene M. Johnson ,  & 

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© 1988 Kluwer Academic Publishers

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Saper, C.B., Standaert, D.G. (1988). Role of Atriopeptin in Central Cardiovascular Control. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_11

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  • DOI: https://doi.org/10.1007/978-1-4613-1721-0_11

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8969-2

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