Abstract
The acidic amino acids, L-glutamate and L-aspartate, appear to be the major excitatory transmitters in the central nervous system. Glutamate, for example, in enriched in select neurons, synthesized in nerve terminals primarily via the enzyme glutaminase, and accumulated by high-affinity uptake. Both endogenous and exogenously loaded L-glutamate exhibit Ca2+-dependent release upon depolarization. Ablation of various neuronal pathways is associated with a modest decrease in glutamate levels and a greater loss of the high-affinity uptake system (for review see [1]).
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© 1988 Kluwer Academic Publishers
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Cotman, C.W. (1988). Excitatory Amino Acid Synapses: Studies of Normal and Reorganized Pathways. In: Ferrendelli, J.A., Collins, R.C., Johnson, E.M. (eds) Neurobiology of Amino Acids, Peptides and Trophic Factors. Topics in the Neurosciences, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1721-0_1
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DOI: https://doi.org/10.1007/978-1-4613-1721-0_1
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