Ternary Complexes of Pt+2 and Pd+2 with Ino, Guo and Amino Acids
Nucleic acids and proteins interact through specific amico acid side chains and nucleic acid bases in biological systems and this may be done with the aid of a metal ion, forming a ternary compex (1,2). The compounds cis-Pt(ino)2Cl2 and cis-Pd(guo)2Cl2 were allowed to react with various amino acids, in order to detect such nucleoside-amino acid interactions, as a first attempt. This may substantiate earlier suggestions of cis-DDP produced DNA-protein crosslinks (3), exhibiting its anticancer properties.
KeywordsSugar Acetone Platinum Glycine Palladium
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- 1.C. Helene, Nucl.Acid.Research, 2, 96 (1975).Google Scholar
- 3.L.A. Zwelling and K.W. Kohn, “CIS PLATIN, Current Status and New Developments”, (Eds. A.W. Prestayko, S.T. Crooke, S.K. Canter), Academic Press, New York etc, Chap.3, p. 21 (1980).Google Scholar
- 5.A.Garoufis, R.Haran, M.Pasdeloup, J.P. Laussac and N .Hadjiliadis, J.Inorg. Bioch., in press.Google Scholar