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Metal-Coordination Chemistry with Biomolecules: Platinum-Nucleobase Interactions

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Part of the book series: Developments in Oncology ((DION,volume 54))

Abstract

This lecture is intended to point out, from an inorganic chemist’s view, some aspects of Pt coordination chemistry involving nucleobases. Most of the studies I will be refering to, have been done with models and therefore, their relevance might be considered limited. However, models developed by coordination chemists, have strongly influenced the thinking of scientists from various disciplines as, on the other hand, observations of biochemists have encouraged inorganic chemists to try to interpret these findings by modeling.

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References

  1. Martin, R.B. Acc. Chem. Res. 18: 32, 1985.

    Article  CAS  Google Scholar 

  2. Beyerle-Pfnür, R., Brown, B., Faggiani, R., Lippert, B. and Lock, C.J.L. Inorg. Chem. 24: 4001, 1985.

    Article  Google Scholar 

  3. Lock, C.J.L., Speranzini, R.A., Turner, G. and Powell, J. J. Am. Chem. Soc. 98: 7865, 1976.

    Article  CAS  Google Scholar 

  4. Den Hartog, J.H.J., van den Eist, H. and Reedijk, J. J. Inorg. Biochem. 21: 83, 1984.

    Article  Google Scholar 

  5. Sigel, H. J. Am. Chem. Soc. 97: 3209, 1975.

    Article  CAS  Google Scholar 

  6. Ford, P., de Rudd, F.P., Gaunder, R. and Taube, H. J. Am. Chem. Soc. 90: 1187, 1986.

    Article  Google Scholar 

  7. Lippert, B. J. Am. Chem. Soc. 103: 5691, 1981.

    Article  CAS  Google Scholar 

  8. Raudaschl-Sieber, G., Schöllhorn, H., Thewalt, U. and Lippert, B. J. Am. Chem. Soc. 107: 3591, 1985.

    Article  CAS  Google Scholar 

  9. Simpson, R.B. J. Am. Chem. Soc. 86: 2059, 1964.

    Article  CAS  Google Scholar 

  10. Korte, H.-J. and Bau, R. Inorg. Chim. Acta 79: 251, 1983.

    Article  Google Scholar 

  11. Lippert, B. Inorg. Chim. Acta 56: L 23, 1981.

    Article  CAS  Google Scholar 

  12. Faggiani, R., Lock, C.J.L. Inorg. Chim. Acta 106: 75, 1985.

    Article  CAS  Google Scholar 

  13. Orbell, J.D., Marzilli, L.G. and Kistenmacher, T.J. J. Am. Chem. Soc. 103: 5126, 1981.

    Article  CAS  Google Scholar 

  14. Faggiani, R., Lippert, B., Lock, C.J.L. Inorg. Chem. 21: 3210, 1982.

    Article  CAS  Google Scholar 

  15. Lock, C.J.L. and Lippert, B., unpublished results.

    Google Scholar 

  16. Lippert, B., Raudaschl, G., Lock, C.J.L. and Pilon, P. Inorg. Chim. Acta 93: 43, 1984.

    Article  CAS  Google Scholar 

  17. Schöllhorn, H., Raudaschl-Sieber, G., Müller, G., Thewalt, U. and Lippert, B. J. Am. Chem. Soc. 107: 5932, 1985.

    Article  Google Scholar 

  18. Van der Veer, J.L., van den Elst, H. and Reedijk, J. Inorg. Chem. 26: 1536, 1987.

    Article  Google Scholar 

  19. Lippert, B. and Neugebauer, D. Inorg. Chim. Acta 46: 171, 1980.

    Article  CAS  Google Scholar 

  20. Lippert, B., Lock, C.J.L. and Speranzini, R.A. Inorg. Chem. 20, 335, 1981.

    Article  CAS  Google Scholar 

  21. Schöllhorn, H., Thewalt, U. and Lippert, B. Inorg. Chim. Acta 124: 207, 1986.

    Article  Google Scholar 

  22. Lippert, B., Neugebauer, D. and Raudaschl, G. Inorg. Chim. Acta 78: 161, 1983.

    Article  CAS  Google Scholar 

  23. Lippert, B. and Neugebauer, D. Inorg. Chem. 21: 451, 1982.

    Article  CAS  Google Scholar 

  24. Lippert, B., Schöllhorn, H. and Thewalt, U. Inorg. Chem. 26: 1736, 1987.

    Article  CAS  Google Scholar 

  25. Mansy, S. and Tobias, R.S. Biochemistry 14: 2952, 1975.

    Article  PubMed  CAS  Google Scholar 

  26. Lippert, B. Inorg. Chim. Acta 55: 5, 1981. (b) Schöllhorn, U., Thewalt, U. and Lippert, B., to be submitted. (c) Krizanovic, O. and Lippert, B., unpublished results.

    Article  CAS  Google Scholar 

  27. Schöllhorn, H., Thewalt, U. and Lippert, B. J. C. S., Chem. Commun. 769, 1984, and references cited therein.

    Google Scholar 

  28. Charland, J.-P., Simard, M. and Beauchamp, A.L. Inorg. Chim. Acta 80: L57, 1983.

    Article  CAS  Google Scholar 

  29. Faggiani, R., Lippert, B., Lock, C.J.L., Speranzini, R.A. J. Am. Chem. Soc. 103: 1111, 1981.

    Article  CAS  Google Scholar 

  30. Britten, J.F., Lippert, B., Lock, C.J.L. and Pilon, P. Inorg. Chem. 21: 1936, 1982.

    Article  CAS  Google Scholar 

  31. Schöllhorn, H., Beyerle-Pfnür, R., Thewalt, U. and Lippert, B. J. Am. Chem. Soc. 108: 3680, 1986.

    Article  Google Scholar 

  32. Den Hartog, J.H.J., Altona C., Chottard, J.-C., Girault, J.-P., Lallemand, J.-Y., de Leeuw, F.A.A.M., Marcelis, A.T.M. and Reedijk, J. Nucl. Acids Res. 10: 4715, 1982.

    Article  Google Scholar 

  33. Sherman, S.E., Gibson, D., Wang, A.H.-J. and Lippard, S.J. Science (Washington), 230: 412, 1985.

    Article  CAS  Google Scholar 

  34. Admiraal, G., van der Veer, J.L., de Graaf, R.A.G., den Hartog, J.H.J. and Reedijk, J. J. Am. Chem. Soc. 109: 592, 1987.

    Article  CAS  Google Scholar 

  35. Sindellari, L., Raudaschl-Sieber, G., Schöllhorn, H., Thewalt, U. and Lippert, B., to be published.

    Google Scholar 

  36. Sundquist, W.I., Lippard, S.J. and Stollar, B.D. Biochemistry 25: 1520, 1986.

    Article  PubMed  CAS  Google Scholar 

  37. Lock, C.J.L. In: Inorganic Chemistry in Biology and Medicine (Ed. Martell, A.E.), ACS Symp. Ser. 140, American Chemical Society, Washington, 1980, pp.210–224.

    Google Scholar 

  38. Faggiani, R., Lippert, B., Lock, C.J.L. and Speranzini, R.A. Inorg. Chem. 21: 3216, 1982.

    Article  CAS  Google Scholar 

  39. Beyerle-Pfnür, R., Lippert, B. and Lock, C.J.L., unpublished results.

    Google Scholar 

  40. Beauchamp, A.L. and Belanger-Gariepy, F. Inorg. Chim. Acta 124: L23, 1986.

    Article  CAS  Google Scholar 

  41. Cozak, D., Mardhy, A., Olivier, M.J. and Beauchamp, A.L. Inorg. Chem 25: 2600, 1986.

    Article  CAS  Google Scholar 

  42. Lippert, B., Lock, C.J.L. and Speranzini, R.A. Inorg. Chem. 20: 808, 1981.

    Article  CAS  Google Scholar 

  43. Quigley, G.J., Ughetto, G., van der Marel, G.A., van Boom, J.H., Wang, A.H.-J. and Rich, A. Science (Washington) 232: 1255, 1986.

    Article  CAS  Google Scholar 

  44. Eichhorn, G.L. Met. Ions Biol. Syst. 10: 1, 1979.

    Google Scholar 

  45. Lippert, B., Schöllhorn, H. and Thewalt, U. J. Am. Chem. Soc. 108: 6616, 1986.

    Article  CAS  Google Scholar 

  46. Brown, T., Hunter, W.N., Kneale, G. and Kennard, O. Proc. Natl. Acad. Sci. USA 83: 2402, 1986.

    Article  PubMed  CAS  Google Scholar 

  47. Hunter, W.N., Brown, T., Anand, N.N. and Kennard, O. Nature 320: 552, 1986.

    Article  PubMed  CAS  Google Scholar 

  48. Drake, J.W., Baltz, R.H. Ann. Rev. Biochem. 45: 11, 1976.

    Article  PubMed  CAS  Google Scholar 

  49. Faggiani, R., Lock, C.J.L. and Lippert, B. J. Am. Chem. Soc. 102: 5418, 1980.

    Article  CAS  Google Scholar 

  50. Fichtinger-Schepman, A.M.J., van der Veer, J.L., den Hartog, J.H.J, Lohman, P.H.M. and Reedijk, J. Biochemistry 24: 707, 1985.

    Article  PubMed  CAS  Google Scholar 

  51. Eastman, A. Biochemistry 25: 3912, 1986.

    Article  PubMed  CAS  Google Scholar 

  52. Eastman, A. Biochemistry 22: 3927, 1983.

    Article  PubMed  CAS  Google Scholar 

  53. Butour, J.-L. and Johnson, Biochemistry 25, 4534, 1986.

    Article  PubMed  CAS  Google Scholar 

  54. Fichtinger-Schepman, A.M.J., van der Veer, J.L., Lohman, P.H.M. and Reedijk, J. J. Inorg. Biochem. 21: 103, 1984.

    Article  CAS  Google Scholar 

  55. Schaller, W., Reisner, H. and Holler, E. Biochemistry 26: 943, 1987.

    Article  PubMed  CAS  Google Scholar 

  56. Saenger, W. Principles of Nucleic Acid Structure. Springer, New York, 1984.

    Google Scholar 

  57. Geliert, R.W. and Bau, R. J. Am. Chem. Soc. 97: 7379, 1975.

    Article  Google Scholar 

  58. Kozelka, J., Petsko, G.A., Quigley, G.J. and Lippard, S.J. Inorg. Chem. 25: 1075, 1986.

    Article  CAS  Google Scholar 

  59. Martin, R.B. In: Platinum, Gold, and Other Metal Chemothera-peutic Agents (Ed. Lippard, S.J.), ACS Symp. Ser. 209, American Chemical Society, Washington, 1983, pp.231–244.

    Chapter  Google Scholar 

  60. Raudaschl-Sieber, G. and Lippert, B. Inorg. Chem. 24: 2426, 1985.

    Article  CAS  Google Scholar 

  61. Johnson, N.P., Mazard, A.M., Escalier, J. and Macquet, J.-P. J. Am. Chem. Soc. 107: 6376, 1985.

    Article  CAS  Google Scholar 

  62. Neugebauer, D. and Lippert, B. Inorg. Chim. Acta 67: 151, 1982.

    Article  CAS  Google Scholar 

  63. Bauer, W., Gonias, S.L., Kam, S.K., Wu, K.C. and Lippard, S.J. Biochemistry 17, 1060, 1978.

    Article  PubMed  CAS  Google Scholar 

  64. Clarke, M.J. Tnorg. Chem. 16: 738, 1977.

    Article  CAS  Google Scholar 

  65. Kastner, M.E., Coffey, K.F., Clarke, M.J., Edmonds, S.E., Eriks, K. J. Am. Chem. Soc. 103: 5747, 1981.

    Article  CAS  Google Scholar 

  66. Clarke, M.J., Taube, H. J. Am. Chem. Soc. 97: 1397, 1975.

    Article  CAS  Google Scholar 

  67. Clarke, M.J. J. Am. Chem. Soc. 100: 5068. 1978.

    Article  CAS  Google Scholar 

  68. Menard, R., Phan Viet, M.T. and Zador, M. Inorg. Chim. Acta 136: 25, 1987.

    Article  CAS  Google Scholar 

  69. Lippert, B. Inorg.Chem. 20: 4326, 1981.

    Article  CAS  Google Scholar 

  70. see ref. 15

    Article  Google Scholar 

  71. O’Halloran, T.V. and Lippard, S.J. J. Am. Chem. Soc. 105: 3341 (1983).

    Article  Google Scholar 

  72. Hollis, L.S., Amundsen A.R. and Stern, E.W. Eur. Pat. Appl. 199524 (1986).

    Google Scholar 

  73. Woollins, J.D. and Rosenberg, B. J. Inorg. Biochem. 19: 41, 1983.

    Article  CAS  Google Scholar 

  74. Hollis, L.S., Stern, E.W., Amundsen, A.R. and Doran, S.L. J. Am. Chem. Soc. 109, in press.

    Google Scholar 

  75. see refs. 37 (structure) and 11 (reactivity).

    Article  Google Scholar 

  76. Lippard, S.J. Science (Washington) 218: 1075, 1982.

    Article  CAS  Google Scholar 

  77. Davidson, J.P., Faber, P.J., Fischer, R.G., Jr., Mansy, S., Peresie, H.J., Rosenberg, B. and VanCamp, L. Cancer Chemother. Rep. Part1, 59: 287, 1975.

    CAS  Google Scholar 

  78. Hofmann, K.A. and Bugge, G. Chem. Ber. 41: 312, 1908.

    Article  CAS  Google Scholar 

  79. Krogmann, K. Angw. Chem. 81: 10, 1969.

    Article  Google Scholar 

  80. Lippert, B. J. Clin. Hematol. 7: 26, 1977.

    CAS  Google Scholar 

  81. Barton, J.K., Rabinowitz, Szalda, D.J. and Lippard, S.J. J. Am. Chem. Soc. 99: 2827, 1977.

    Article  CAS  Google Scholar 

  82. O’Halloran, T.V., Mascharak, P.K., Williams, I.D., Roberts, M.M. and Lippard, S.J. Inorg. Chem. 26: 1261, 1987.

    Article  Google Scholar 

  83. Hollis, L.S. and Lippard, S.J. Inorg. Chem. 22: 2605, 1983.

    Article  CAS  Google Scholar 

  84. Matsumoto, K. Bull. Chem. Soc. Jpn. 58: 651, 1985 and references cited therein.

    Article  CAS  Google Scholar 

  85. Micklitz, W., Müller, G., Riede, J. and Lippert, B. J. C. S., Chem. Commun., 76, 1987.

    Google Scholar 

  86. Muraveiskaya, G.S. Dokl.Akad. Nauk SSSR 226: 596, 1976.

    CAS  Google Scholar 

  87. O’Halloran, T.V. and Lippard, S.J. Isr. J. Chem. 25: 130, 1985.

    Google Scholar 

  88. Woollins, J.D. and Kelly, P.F. Coord. Chem. Rev. 65: 115, 1985.

    Article  CAS  Google Scholar 

  89. Schöllhorn, H., Thewalt, U. and Lippert, B. J. C. S., Chem. Commun. 258, 1986.

    Google Scholar 

  90. Schöllhorn, H., Eisenmann, P., Thewalt, U. and Lippert, B. Inorg. Chem. 25: 3384, 1986.

    Article  Google Scholar 

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Authors
  1. B. Lippert
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  2. J. Arpalahti
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  3. O. Krizanovic
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  4. W. Micklitz
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  5. F. Schwarz
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  6. G. Trötscher
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Editors and Affiliations

  1. University of Padua, Padua, Italy

    Marino Nicolini

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© 1988 Martinus Nijhoff Publishing, Boston

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Lippert, B., Arpalahti, J., Krizanovic, O., Micklitz, W., Schwarz, F., Trötscher, G. (1988). Metal-Coordination Chemistry with Biomolecules: Platinum-Nucleobase Interactions. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_64

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  • DOI: https://doi.org/10.1007/978-1-4613-1717-3_64

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