A Coordination Chemical Approach to Prepare Organ-Specific Antitumor Platinum Complexes in Cancer Chemotherapy

  • Y. Kidani
Part of the Developments in Oncology book series (DION, volume 54)

Abstract

Since the discovery of the antitumor activity of cis-Platin by Rosenberg et al. in 1969, it has become one of the most useful antitumor agents in cancer chemotherapy. With the view to develop superior 2nd generation Pt complexes to cis-Platin, without kidney and unfavorable toxicity, the author is conducting a coordination chemical approach to prepare organ-specific antitumor complexes. Metal complexes are represented by he chemical formula,

(Carrier Ligand)—(Pt)—(Leaving Group)

Keywords

Toxicity HPLC Benzene Platinum Leukemia 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Kidani, Y. Yakugaku Zasshi, 105, 909–925, 1985.PubMedGoogle Scholar
  2. 2.
    Mathé, G., Kidani, Y., Noji, M., Maral, R., Bourut, C., Ehenu,E., Cancer Letts., 27, 135–143, 1985.CrossRefGoogle Scholar
  3. 3.
    Mathé, G., Kidani, Y., Triana, K., Brienza, S., Ribaud, P., Goldschmidt, E., Exstein, E., Dspak, R., Musset, M., Misset, J.L. Biomedicine Pharmacotherapy, 40, 372–376, 1986.PubMedGoogle Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • Y. Kidani

There are no affiliations available

Personalised recommendations