A Coordination Chemical Approach to Prepare Organ-Specific Antitumor Platinum Complexes in Cancer Chemotherapy
Part of the Developments in Oncology book series (DION, volume 54)
Since the discovery of the antitumor activity of cis-Platin by Rosenberg et al. in 1969, it has become one of the most useful antitumor agents in cancer chemotherapy. With the view to develop superior 2nd generation Pt complexes to cis-Platin, without kidney and unfavorable toxicity, the author is conducting a coordination chemical approach to prepare organ-specific antitumor complexes. Metal complexes are represented by he chemical formula,
(Carrier Ligand)—(Pt)—(Leaving Group)
KeywordsToxicity HPLC Benzene Platinum Leukemia
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© Martinus Nijhoff Publishing, Boston 1988