Abstract
It has now been some eighteen years since Rosenberg’s momentous discovery of the antitumor activity of cisplatin (1). In the intervening period, cisplatin has become established as a leading anticancer agent and a great deal has been learned concerning its activity and toxicity as well as the nature of its interaction with its presumed biological target, DNA (2,3). During the same interval, several thousand platinum and, perhaps, a hundred or so other metal complexes have been synthesized and evaluated in various model tumor systems in hopes of discovering new drugs with improved properties. Of these, only a relatively small number have entered clinical trials and only one, carboplatin, has, to date, received regulatory approval and been commercialized. At this time it would be useful to review the requirements for an improved platinum drug, along with what has been acomplished so far in meeting these, what problems have been encountered, and what future progress is likely.
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Stern, E.W. (1988). The Search for New Platinum Antitumor Agents: Progress, Problems and Prospects. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_60
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_60
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