Abstract
After 20 years of research we got insight into the molecular pharmacodynamic of platinum drugs, i.e. we can draw the structure of the complex formed between the platinum atom and the DNA molecule which is responsible for the cytostatic effect. We have also collected enough evidence supporting the hypothesis that the block of cytokinesis is part of a complex cellular response to specific DNA damage induced by platinum coordination compounds with cis-position of leaving ligands.
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© 1988 Martinus Nijhoff Publishing, Boston
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Drobnik, J. (1988). Macromolecular Antitumor Drugs: Pharmacology and Biology. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_5
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8967-8
Online ISBN: 978-1-4613-1717-3
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