Chemotherapy of Head and Neck Cancer

  • A. Choksi
  • W. K. Hong
Part of the Developments in Oncology book series (DION, volume 54)

Abstract

It is estimated that in the U.S.A. in 1987, there will be 29,800 new cases of cancer of the oral cavity and pharynx and 12,100 new cases of cancer of the larynx (1). Overall 5-year survival of head and neck cancer (HNCa) is 54% (2). Patients (pts) presenting with early disease can be cured with surgery and/or XRT. These treatment methods have not provided adequate tumor control in the majority of pts who present with advanced local and regional disease. Following initial treatment, up to 60% of these pts develop local recurrences: 20% to 30% develop distant metastases, and 10% to 40% also develop second primary malignancies (3). Traditionally, chemotherapy (CT) has been used as a palliative agent in recurrent and/or metastatic tumors. Induction CT in untreated locally advanced pts is under intensive investigation at present.

Keywords

Toxicity Platinum Hydrocortisone Oncol Methotrexate 

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Copyright information

© Martinus Nijhoff Publishing, Boston 1988

Authors and Affiliations

  • A. Choksi
  • W. K. Hong

There are no affiliations available

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