Abstract
The substitution of the two NH3 groups in cisplatinum (cDDP) by ethylene diamine ligands leads to complexes with good pharmacological activity against experimental tumors (1). Our aim was to increase the activity/toxicity ratio and also to provide compounds against tumors which are either nonresponsive or resistant to cisplatinum. We prepared new platinum complexes of 1,2-diaminoethanes derived from phenylalanine.
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Literature
Brunner, H., Schmidt, M., Unger, G. and Schoenenberger H. Eur. J. Med. Chem. — Chim. Ther. 20:509-512, 1985.
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© 1988 Martinus Nijhoff Publishing, Boston
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Voegeli, R. et al. (1988). Synthesis and Therapeutic Effect of New Cis-Platinum Complexes on Experimental Tumors. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_40
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_40
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8967-8
Online ISBN: 978-1-4613-1717-3
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