Abstract
Recently, the use of reducing thiols and reduced glutathione (GSH) has been proposed in vivo in an attempt to lower cis-platinum (DDP) induced nephrotoxicity. Thiol-containing compounds have been tested as antidotal agents, since toxic effects of DDP are reminiscent of heavy metal intoxication (1). It is well known that the nephrotoxicity of the heavy metals appears to be related to a depletion of intracellular GSH or attachment to SH groups of proteins necessary for enzyme function (2). Also the nephrotoxic effect of DDP may be related to depletion of SH groups.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Borch, R.F. and Pleasants, M.E. Proc. Natl. Acad. Sci. USA 76: 6611–6614, 1979.
Clarkson, T.W. Ann. Rev. Pharmacol. 12: 375–406, 1972.
Borch, R.F., Bodenner, D.L. and Katz, J.C. In: Platinum Coordination Complexes in Cancer Chemotherapy (Eds. M.P. Hacker, E.B. Bouple and I.H. Krakess), Martinus Nijhoff, Boston, 1984, p. 154.
Hamburger, A.W. and Salmon, S.E. Science 197: 461–463, 1977.
Volm, M., Kaufmann, M., Hinderer, H. and Goerttler, K. Klin. Wochenschr. 48: 374–376, 1970.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Martinus Nijhoff Publishing, Boston
About this chapter
Cite this chapter
Stefanelli, S., Faggionato, O., Peracchi, M., Carrara, M., Cima, L., Fiorentino, M.V. (1988). Cisplatin Interactions with Reduced Glutathione: An in Vitro Study. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_38
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1717-3_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8967-8
Online ISBN: 978-1-4613-1717-3
eBook Packages: Springer Book Archive