Summary
Interference of thio-compounds with cis-DDP in vitro on metastatic subline of murine B16 melanoma was investigated.
Our results confirm a protective role exerted in vitro by Mesna on cis-DDP toxicity. CPDS and 2,2′-PDS, two “thione-forming” disulfides show, on the contrary, a synergic effect with cis-DDP: it suggests their possible role in sensitizing tumor cells to anticancer drugs (through a changing of cell surface, a reduction of GSH content and/or an inhibition of poly A formation). The possible mechanisms of the interactions between thio-compounds and cis-DDP are discussed.
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© 1988 Martinus Nijhoff Publishing, Boston
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Magnolfi, G., D’Ancona, S., Berti, T. (1988). Interference of Thio-Compounds with Cis-Diamminodichloroplatinum (DDP) on Tumor Cells in Vitro . In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_36
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_36
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