Abstract
For the maximum potential of an antineoplastic drug to be realized, a torough understanding of its pharmacology “in vivo” is essential. The investigation, therefore, on the tissue distribution of Platinum are interesting both from a pathophysiology point of view, as they give an insight into the mechanism leading to different tissue concentrations of this drug, and from a clinical point of view, since they provide a pharmocological explanation for organ-specific toxicity or for antitumor activity.
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© 1988 Martinus Nijhoff Publishing, Boston
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Arslan, P., Cagol, P.P., Da Pian, P.P., Pilati, P.L., Gori, P., Beltrame, M. (1988). Administration Route of Cis-Platinum Plays an Important Role in the in Vivo Pharmacokinetics. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_28
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_28
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