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Cisplatin Efficacy and Toxicity: Are they Separable?

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Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy

Part of the book series: Developments in Oncology ((DION,volume 54))

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Abstract

Rosenberg first reported the antitumor activity of cis-diamminedichloroplatinum (II) (DDP) in 1969 and since that time DDP has become one of the most widely used cancer chemotherapeutic drugs in the clinic. DDP has marked activity in several types of tumors including testicular, ovarian and head and neck carcinomas (1–3). In spite of the impressive activity of DDP in selected tumors a number of factors, such as a limited spectrum of responsive tumors, severe host toxicity, the development of resistance by tumor cells and relatively poor water solubility, have hampered the clinical usefulness of this drug.

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References

  1. Einhorn, L.H. and Williams, S.D. N. Engl. J. Med. 300:289–291, 1979.

    Article  PubMed  CAS  Google Scholar 

  2. Prestayko, A.W., D’Aoust, J.C., Issell, B.F. and Crooke, S.T. Cancer Treat Rev. 6: 17–39, 1979.

    Article  PubMed  CAS  Google Scholar 

  3. Burchenal, J.H. Biochimie 60:915–919, 1978.

    Article  Google Scholar 

  4. Van Hoff, D.D., Schilsky, R., Reichert, C.M., Reddick, R.L., Rosencweig, M., Young, R.C. and Muggia, F.M. Cancer Treat. Rep. 63:1527–1531, 1979.

    Google Scholar 

  5. Rosencweig, M., Von Hoff, D.D., Slavik, M. and Muggia, F.M. Ann. Intern. Med. 86:803–812, 1977.

    Google Scholar 

  6. Dentino, M., Luft, F.C., Yum, M.N., Williams, S.D. and Einhorn, L.H. Cancer 41:1274–1281, 1978.

    Article  PubMed  CAS  Google Scholar 

  7. Schilsky, R.L. Semin. Oncol. 9:75–83, 1982.

    PubMed  CAS  Google Scholar 

  8. Meijes, S., Sleisfer, D., Molder, N.H., Sluiter, W.J., Marrink, J. and Schraffordt, H. Cancer 51:2035–2040, 1983

    Article  Google Scholar 

  9. Safirstein, R., Miller, P., Dikman, S., Lyman, N. and Shapiro, C. Am. J. Physiol. 241:F175-F185, 1982

    Google Scholar 

  10. Daugaard, G. and Rrth, M. Eur. J. Clin. Oncol. 22:477–485, 1986.

    Article  Google Scholar 

  11. Pera, M.F., Jr., Zook, B.C. and Harder, H.C. Cancer Res. 39:1269–1275, 1979.

    PubMed  CAS  Google Scholar 

  12. Litterst, C.L., Tox. Appl. Pharmacol. 61:99–108, 1981.

    Article  CAS  Google Scholar 

  13. Ozols, R.F., Corden, B.J., Jacob, J., Wesley, M.N., Ostchega, Y., and Young, R.C. Ann. Intern. Med. 100:19–24, 1984.

    PubMed  CAS  Google Scholar 

  14. Ozols, R.F., Corden, B.J., Collins, J. and Young, R.C. In: Platinum Coordination Complexes in Cancer Chemotherapy (Eds. Hacker, M.P., Douple, E.B., Krakoff, I.H.). 1984, pp. 321–329.

    Google Scholar 

  15. Bodenner, D.L., Dedon, P.C., Keng, P.C. and Borch, R.F. Cancer Res. 46:2745–2750, 1986.

    PubMed  CAS  Google Scholar 

  16. Dedon, P.C. and Borch, R.F. Biochem. Pharmacol. 36: In press, 1987.

    Google Scholar 

  17. Markman, M., Cleary, S. and Howell, S.B. Eur. J. Cancer Clin. Oncol. 21:1015–1018, 1985.

    Article  PubMed  Google Scholar 

  18. Nagy, B., Dale, P.J. and Grdina, D.J. Cancer Res. 46:1132–1135, 1986.

    PubMed  CAS  Google Scholar 

  19. Ozols, R.F., Reed, E., Poirier, M.C. and Young, R.C. Presented at the First International Symposium on Organ Directed Toxicities of Anticancer Drugs, Burlington, VT, June 1987.

    Google Scholar 

  20. Oriana, S., Spatti, G.B., Bohm, S., Tognella, S., Tedeschi, M., Zunino, F. and DiRe, F. Presented at the First International Symposium on Organ Directed Toxicities of Anticancer Drugs, Burlington, VT, June 1987.

    Google Scholar 

  21. Calvert, A.H., Harland, S.J., Harrap, K.R., Wiltshaw, E. and Simita, I.E. In: Platinum Coordination Complexes in Cancer Chemotherapy (Eds. Hacker, M.P., Douple, E.B. and Krakoff, I.H.), 1984, pp. 240–251.

    Google Scholar 

  22. Anderson, W.K., Quagliato, D.A., Haugwitz, R.D., Narayanan, V.L. and Wolpert-DeFillipes, M.K. Cancer Treat Rep. 70:997–1002, 1986.

    PubMed  CAS  Google Scholar 

  23. Gylys, J.A., Doran, K.M. and Buyniski, J.P. Res. Commun. Chem. Pathol. Pharmacol. 23:61–68, 1979.

    PubMed  CAS  Google Scholar 

  24. Schurig, J.E., Florczyk, A.P. and Bradner, W.T. In: Platinum Coordination Complexes in Cancer Chemotherapy (Eds. Hacker, M.P., Douple, E.B. and Krakoff, I.H.) 1984, pp. 187–199.

    Google Scholar 

  25. Kris, M.G., Gralla, R.J. and Tyson, L.B. Cancer 55:527–534, 1985.

    Article  PubMed  CAS  Google Scholar 

  26. Strum, S.B. and McDermed, J.E. Cancer Treat. Rep. 62:1049–1050, 1983.

    Google Scholar 

  27. Allan, S.G., Cornbleet, M.A. and Warrington, P.S. Brit. Med. J. 289:878–879, 1984.

    Google Scholar 

  28. Kris, M.G., Gralla, R.J., Clark, R.A., Tyson, L.B., O’Connell, J.P., Wertheim, M.S. and Kelsen, D.P. J. Clin. Oncol. 3:1379–1384, 1985.

    PubMed  Google Scholar 

  29. Technical Report to the National Cancer Institute, 1979.

    Google Scholar 

  30. Kovach, J.S., Moertel, CG., Schutt, A.J., Reitomeier, R.G., and Hahn, R.G. Cancer Chemo Rep. 57:351–362, 1973.

    Google Scholar 

  31. Guarino, A.M., Miller, D.S., Arnold, S.T., Pritchard, J.B., Davis, R.D., Urbanek, M.A., Miller, T.J. and Litterst, C.L. Cancer Treat Rep. 63:1475–1483, 1979.

    PubMed  CAS  Google Scholar 

  32. Vermoken, J.B., Kapteijn, T.S. and Hart, A.A. Cancer Clin. Oncol. 19:53–58, 1983.

    Article  Google Scholar 

  33. Schweitzer, V.G., Dolan, D.F., Abrams, G.E., Davidson, T., and Snyder, R. Laryngo. 96:948–958, 1986.

    CAS  Google Scholar 

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Authors
  1. M. P. Hacker
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  2. J. D. Roberts
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Editor information

Editors and Affiliations

  1. University of Padua, Padua, Italy

    Marino Nicolini

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© 1988 Martinus Nijhoff Publishing, Boston

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Hacker, M.P., Roberts, J.D. (1988). Cisplatin Efficacy and Toxicity: Are they Separable?. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_19

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  • DOI: https://doi.org/10.1007/978-1-4613-1717-3_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8967-8

  • Online ISBN: 978-1-4613-1717-3

  • eBook Packages: Springer Book Archive

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