Abstract
We are interested in the contribution of cisplatin- (cis-diamminedichloroplatinum, cDDP) and carboplatin- (cis-diammine (1,1-cyclobutanedicarboxylato)-platinum(II), CBDCA) induced DNA modifications to the cytotoxic and other biological effects of these drugs. An antiserum against in vitro cDDP modified DNA was therefore applied in an immunocytochemical double peroxidase assay. It proved to be possible to visualize cDDP-DNA and CBDCA-DNA binding both in tissues and cultured cells (1).
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© 1988 Martinus Nijhoff Publishing, Boston
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Terheggen, P., Begg, A.C., Floot, B., Emondt, J., Den Engelse, L. (1988). Visualization of Cisplatin-DNA and Carboplatin-DNA Adducts in Tissues and Cultured Cells. In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_17
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_17
Publisher Name: Springer, Boston, MA
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