Abstract
Numerous studies support the concept that DNA is the likely target for the antitumor drug cis-diamminedichloroplatinum (II) (cis-DDP) (1–3). Most of the adducts formed in the reaction of cis-DDP and DNA have been identified (4–6). Two major adducts arise from an intrastrand cross-link between two adjacent guanine residues and between adjacent adenine and guanine residues. Minor adducts arise from intrastrand cross-links between two guanine residues separated by one base and from interstrand cross-links between two guanine residues.
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© 1988 Martinus Nijhoff Publishing, Boston
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Rahmouni, A., Schwartz, A., Leng, M. (1988). Importance of DNA Sequence in the Reaction of d(ApG) and d(GpA) with Cis-Diamminedichloroplatinum (II). In: Nicolini, M. (eds) Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy. Developments in Oncology, vol 54. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1717-3_15
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DOI: https://doi.org/10.1007/978-1-4613-1717-3_15
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