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Clinical Use of Foscarnet (Phosphonoformate)

  • B. Öberg
  • S. Behrnetz
  • B. Eriksson
  • H. Jozwiak
  • A. Larsson
  • J. O. Lernestedt
  • V. Lindsö Aberg
Part of the Developments in Medical Virology book series (DIMV, volume 3)

Abstract

Foscarnet is a selective inhibitor of several viral DNA polymerases. When used topically, foscarnet has a limited effect on recurrent mucocutaneous herpes, possibly due to the rapid course of virus replication. In immunocompromised patients with severe CMV infections, parenteral foscarnet has beneficial effects especially against CMV retinitis in AIDS patients. Preliminary data indicate that parenteral foscarnet decreases HIV replication in vivo. Following iv treatment with foscarnet for two weeks or longer and with median daily doses of 6 to 10 g in different subgroups of patients, transient renal impairment, decreases in haemoglobin concentration and calcium have been observed. Effects on the central nervous system, e.g. hallucinations and tremor, may be associated with high plasma foscarnet levels.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Graft Versus Host Disease Renal Transplant Patient Genital Herpes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Martinus Nijhoff Publishing 1988

Authors and Affiliations

  • B. Öberg
    • 1
  • S. Behrnetz
    • 2
  • B. Eriksson
    • 2
  • H. Jozwiak
    • 2
  • A. Larsson
    • 2
  • J. O. Lernestedt
    • 2
  • V. Lindsö Aberg
    • 2
  1. 1.Department of Antiviral ChemotherapyASTRA ALAB ABSödertäljeSweden
  2. 2.Department of Clinical ResearchASTRA ALAB ABSödertäljeSweden

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