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Detection of central nervous system involvement in patients with leukemia or non-Hodgkin’s lymphoma by immunological marker analysis of cerebrospinal fluid cells

  • Chapter
Immunologic Approaches to the Classification and Management of Lymphomas and Leukemias

Part of the book series: Cancer Treatment and Research ((CTAR,volume 38))

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Abstract

Central nervous system (CNS) involvement is observed at diagnosis in up to 20% of all patients with acute lymphoblastic leukemia (ALL), acute myeloid leukemia (AML), or non-Hodgkin’s lymphoma (NHL) [1–12]. Follow-up of these patients revealed that without prophylactic CNS therapy, up to 70% of the ALL, up to 25% of the AML, and, depending on the histological subtype, up to 40% of the NHL patients will develop the serious complication of CNS involvement [1, 5, 7, 12–26]. This increase in CNS involvement has been explained by the application of improved systemic therapy leading to longer survival of patients, which allows the growth of tumor cells present in relatively therapy-resistent sites such as the CNS. In addition, primary NHL can be located in the CNS, and they constitute about 1% of all brain tumors and about 2% of all NHL [27–30]. These primary NHL located in the CNS are increasingly diagnosed, especially in immunodeficient individuals, probably as a result of the increased use of radiotherapy and immunosuppressive drugs; furthermore, improved diagnostic procedures might be responsible for this increase [31–36].

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Authors
  1. Herbert Hooijkaas
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  2. Henk J. Adriaansen
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  3. Jacques J. M. van Dongen
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Editors and Affiliations

  1. University of Rochester Cancer Center, Rochester, New York, 14642, USA

    John M. Bennett

  2. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, 48109, USA

    Kenneth A. Foon

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Hooijkaas, H., Adriaansen, H.J., van Dongen, J.J.M. (1988). Detection of central nervous system involvement in patients with leukemia or non-Hodgkin’s lymphoma by immunological marker analysis of cerebrospinal fluid cells. In: Bennett, J.M., Foon, K.A. (eds) Immunologic Approaches to the Classification and Management of Lymphomas and Leukemias. Cancer Treatment and Research, vol 38. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1713-5_3

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  • DOI: https://doi.org/10.1007/978-1-4613-1713-5_3

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