Immunologic approaches to the classification of non-Hodgkin’s lymphomas

  • Thomas M. Grogan
  • Catherine M. Spier
  • Lynne C. Richter
  • Catherine S. Rangel
Part of the Cancer Treatment and Research book series (CTAR, volume 38)


This chapter employs the working formulation (WF) of the non-Hodgkin’s lymphomas as a histologic base, because its ten morphologic categorizations are well defined and of established clinical utility, identifying prognostic gradations relevant to therapy [1]. Using this firm histologic base, the immunologic characteristics within each category are emphasized. As this chapter repeatedly demonstrates, many immunologic subtypes exist within certain WF categories, and these cannot always be predicted by morphologic classification [2]. Figure 1A details the WF categorizations relevant to the previously widely used Rappaport classification [3]. Figure 1B details some closely related entities to be discussed. Some of these represent lymphoma-related diseases, others represent newer categorizations derived from immunologic studies (e.g., peripheral T-cell lymphoma).


Follicular Lymphoma Malignant Lymphoma Acquire Immune Deficiency Syndrome Mycosis Fungoides Hairy Cell Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Thomas M. Grogan
  • Catherine M. Spier
  • Lynne C. Richter
  • Catherine S. Rangel

There are no affiliations available

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