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Influenza Virus and Reye’s Syndrome

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Clinical and Molecular Aspects of Neurotropic Virus Infection

Part of the book series: Developments in Medical Virology ((DIMV,volume 5))

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Abstract

In 1963, in Australia, Reye, Morgan and Baral reported 21 cases of a newly recognized clinical and pathologic entity (1). In the children they studied, a mild prodromal illness of malaise, cough, sore throat, ear ache, and rhinorrhea usually occurred. One to three days later severe vomiting, convulsions and profoundly disturbed consciousness developed. Seventeen children died. At autopsy, all had cerebral edema and fatty metamorphosis of the viscera. That same year in the United States, Johnson et al. reported 16 children with a similar illness (2). These investigators noted that the peak incidence of the cases coincided with an influenza B virus epidemic that was present in North Carolina. The association of Reye’s syndrome with influenza virus dates back to the original pair of observations. This chapter will review the clinical, biochemical, pathologic and experimental studies that focus on the association between influenza virus and Reye’s syndrome.

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References

  1. Reye, R.D.K., Morgan, G., and Baral J, Lancet 2: 749–752, 1963.

    Article  PubMed  CAS  Google Scholar 

  2. Johnson, G.M., Scurletis, T.D., and Carroll, N.B. North Carolina Med. 24:464–473, 1963.

    CAS  Google Scholar 

  3. Utian, H.L., Wagner, J.M., and Sichel, R.J.S. Lancet 2:1043–1045, 1964.

    Article  PubMed  CAS  Google Scholar 

  4. Randolph, M.R., Kranwinkel, R., Johnson, R., and Gelfman, N.A. A. J. Dis. Child. 110:519–532, 1965.

    Google Scholar 

  5. Golden, G.S., and Duffell, D. Pediatr. 36:67–74. 1965.

    CAS  Google Scholar 

  6. Becroft, D.M.O. Brit. Med. J. 2:135–140, 1966.

    Article  PubMed  CAS  Google Scholar 

  7. Dvorackova, I., Vortel, V. and Hroch, M. Arch. Path. 81:240–246, 1966.

    Google Scholar 

  8. Human, D.G. S. African Med. J. 50:1450–1451, 1976.

    CAS  Google Scholar 

  9. Rogers, M.F., Schonberger, L.B., Hurwitz, E.S., and Rowley, D.L. Pediatr. 75:260–264, 1985.

    CAS  Google Scholar 

  10. Communicable Disease Surveillance Center. Brit. Med. J. 291:329–330, 1985.

    Article  Google Scholar 

  11. Sullivan-Bolyai, J.Z., and Corey, L. Epidemiol. Rev. 3:1–26, 1981.

    PubMed  CAS  Google Scholar 

  12. Reynolds, D.W., Riley, H.D., Lafont, D.S., Vorse, H., Stout, L.C., and Carpenter, R.L. J. Pediatr. 80:429–432, 1972.

    Article  PubMed  CAS  Google Scholar 

  13. Hochberg, F.H., Nelson, K., and Janzen, W. JAMA 231:817–821, 1975.

    Article  PubMed  CAS  Google Scholar 

  14. Linnemann, C.C. Jr., Shea, L., Kaufman, C.A., Schiff, G.M., Partin, J.C., and Schubert, W.K. Lancet 2:179–182, 1974.

    Article  PubMed  Google Scholar 

  15. Corey, L., Rubin, R.J., Hattwick, M.A.W., Noble, G.R., Cassidy, E. Am. J. Med. 61:615–625, 1976.

    Article  PubMed  CAS  Google Scholar 

  16. Morbidity and Mortality Weekly Report. 29:27, 1980.

    Google Scholar 

  17. Corey, L., Rubin, R.J., Thompson, T.R., Noble, G.R., Cassidy, E., Hattwick, M.A.W., Gregg, M.B., and Eddins, D. J. Infect. Dis. 135:398–407, 1977.

    Article  CAS  Google Scholar 

  18. Linnemann, C.C., Shea, L., Partin, J.C., Schubert, W.K., and Schiff, G.M. J. Epidemiol. 101:517–526. 1975.

    Google Scholar 

  19. Davis, L.E., and Kornfeld, M. J. Neurol. Neurosurg. Psychiat. 43:516–521, 1980.

    Article  CAS  Google Scholar 

  20. Partin, J.C., Schubert, W.K., Partin, J.S., Jacobs, R., and Saalfeld, K. Lancet 2:599–602, 1976.

    Article  PubMed  CAS  Google Scholar 

  21. Visudhiphan, D. and Chatiyanonda, K. Southeast Asian J. Trop. Med. Pub. Health 6:260–263, 1975.

    CAS  Google Scholar 

  22. Ruben, F.L., and Michaels, R.H. JAMA 234:410–412, 1975.

    Article  PubMed  CAS  Google Scholar 

  23. Nelson, D.B., Hurwitz, E.S., Sullivan-Bolyai, J.Z., Morens, D.M., and Schonberger, L.B. J. Infect. Dis. 140:436–439, 1979.

    Article  CAS  Google Scholar 

  24. Halsey, N.A., Hurwitz, E.S., Meiklejohn, G., Todd, W.A., Edell, T., Todd, J.K., and Mcintosh, K. J. Pediatr. 97:535–539, 1980.

    Article  PubMed  CAS  Google Scholar 

  25. Huttenlocher, P.R., and Trauner, D.A. Pediatr. 62:62–84, 1978.

    Google Scholar 

  26. Bellman, M.H., Ross, E.M., and Miller, D.L. Arch. Dis. Child. 57:259–263, 1982.

    Article  PubMed  CAS  Google Scholar 

  27. Atkins, J.N., and Haponik, E.F. Am. J. Med. 67:672–678, 1979.

    Article  PubMed  CAS  Google Scholar 

  28. Hurwitz, E.S., Nelson, D.B., Davis, C., Morens, D., and Schonberger, L.B. Pediatr. 70:895–900, 1982.

    CAS  Google Scholar 

  29. Corey, L., Rubin, R.J., Hattwick, M.A.W., Noble, G.R., and Cassidy, E. Pediatr. 60:702–708, 1977.

    CAS  Google Scholar 

  30. DeVivo, D.C. Neurol. Clin. 3:95–115, 1985.

    CAS  Google Scholar 

  31. DeVivo, D.C. J. Nat. Reye’s Syndr. Found. 4: 39–47, 1983.

    Google Scholar 

  32. Trauner, D.A. Current Probl. in Pediatr. 12:1–31. 1982.

    CAS  Google Scholar 

  33. Davis, L.E.SPI In: Handbook of Clinical Neurology (Eds. R. McKendall, P.J. Vinken, and G.W. Bruyn), North-Holland, Amsterdam, (in press).

    Google Scholar 

  34. Lovejoy, Jr., F.H., Smith, A.L., Bresnan, M.J., Wood, J.N., Victor, D.I., and Adams, P.C. Am. J. Dis. Child. 128:36–41, 1974.

    PubMed  Google Scholar 

  35. Heubi, J.E., Daugherty, C.C., Partin, J.S., Partin, J.C., and Schubert, W.K. N. Engl. J. Med. 311:1539–1542, 1984.

    Article  PubMed  CAS  Google Scholar 

  36. Brown, R.E., and Forman, D.T. Crit. Rev. Clin. Lab. Sci. 17:247–297, 1982.

    Article  PubMed  Google Scholar 

  37. Roe, C.R., Schonberger, L.B., Gelbach, S.H., Wies, L.A., and Sidbury, J.B. Pediatr. 55:119–126, 1975.

    CAS  Google Scholar 

  38. Huttenlocher, P.R., Schwartz, A.D., and Klatskin, G. Pediatr. 43:443–454, 1969.

    CAS  Google Scholar 

  39. Juggi, J.S., Iyngkaran, N., and Prathap, K. SPIIn: Reye’s syndrome II (Ed. J.F.S. Crocker), Grune and Stratton, 1979, pp.411–432.

    Google Scholar 

  40. Tonsgard, J.H., Huttenlocher, P.R., and Thisted, R.A. Pediatr. 69:64–69, 1982.

    CAS  Google Scholar 

  41. Trauner, D.A., Stockard, J.J., and Sweetman, L. Arch. Neurol. 34:116–118, 1977.

    PubMed  CAS  Google Scholar 

  42. Ogburn, P.L., Sharp, H., Lloyd-Still, J.D., Johnson, S.B., and Holman, R.T. Proc. Natl. Acad. Sci. 79:908–911, 1982.

    Article  PubMed  CAS  Google Scholar 

  43. Brown, T., Hug, G., Lansky, L., Bove, K., Scheve, A., Ryan, M., Brown, H., Schubert, W.K., Partin, J.C., and Lloyd-Still, J. N. Engl. J. Med. 294:861–866. 1976.

    Article  CAS  Google Scholar 

  44. Snodgrass, P.J., and De Long, G.R. N. Engl. J. Med. 294:855–860, 1976.

    Article  CAS  Google Scholar 

  45. Bove, K.E., McAdams, A.J., Partin, J.C., Partin, J.S., Hug, G., and Schubert, W.K. Gastroenterol. 69:685–697, 1975.

    CAS  Google Scholar 

  46. DeVivo, D.C. and Keating, J. P. Adv. Pediatr. 22:175–229, 1976.

    PubMed  CAS  Google Scholar 

  47. Svoboda, D.J., and Reddy, J.K. Lab. Invest. 32:571–579, 1975.

    PubMed  CAS  Google Scholar 

  48. Partin, J.C., Schubert, W.K., and Partin, J.S. N. Engl. J. Med. 285:1339–1343, 1971.

    Article  CAS  Google Scholar 

  49. Iancu, T.C., Mason, W.H., and Neustein, H.B. Human Path. 8:421–431, 1977.

    Article  CAS  Google Scholar 

  50. Chang, L.W., Gilbert, E.F., Tanner, W., and Moffat, H.L. Arch. Pathol. 96:127–132, 1973.

    PubMed  CAS  Google Scholar 

  51. Brown, R.E., and Madge, G.E. Arch. Patho. 92:244–247, 1971.

    CAS  Google Scholar 

  52. Glick, T.H., Ditchek, N.T., Salitsky, S., and Freimuth, E.J. A. J. Dis. Child. 119:68–71, 1970.

    CAS  Google Scholar 

  53. Pronstin, M.H., Moore, L.W., Ruffolo, E.H., and Hooper, G.S. Clin. Pathol. 49:704–709, 1968.

    Google Scholar 

  54. Evans, H., Bourgeois, C.H., Comer, D.S., and Keschamras, N. Arch. Path. 90:543–546, 1970.

    PubMed  CAS  Google Scholar 

  55. Manz, H.J., Colon, A.R., and McCullough, D.C. J. Nat. Reyes Synd. Found. 2:3–19, 1981.

    Google Scholar 

  56. Cullity, G.J., and Kakulas, B.A. Brain 93:77–88. 1970.

    Article  PubMed  CAS  Google Scholar 

  57. Linnemann, C.C., Ueda, K., Hug, G., Schaeffer, A., Clark, A., and Schiff, G.M. Pediat. Res. 13:517–44–47, 1979.

    Article  Google Scholar 

  58. Deshmukh, D.R., Maassab, H.F., and Mason, M. Proc. Natl. Acad. Sci. 79:7557–7560, 1982.

    Article  PubMed  CAS  Google Scholar 

  59. Deshmukh, D.R., and Thomas, P.E. Lab. Animal Sci. 35:242–245, 1985.

    CAS  Google Scholar 

  60. Deshmukh, D.R., Shope, T.C. J. Nutr. 113:1664–1667. 1983.

    PubMed  CAS  Google Scholar 

  61. Sugg, J.Y. J. Bact. 57:399–403, 1949.

    Google Scholar 

  62. Pierson, D., Knight, V., Hansard, P., and Chan, E. Proc. Soc. Exp. Biol. Med. 152:67–70. 1976.

    PubMed  CAS  Google Scholar 

  63. Crocker, J.F.S., Renton, K.W., Lee, S.H., Rozee, K.R., Digout, S.C., and Malatjalian, D.A. Lab. Invest. 54:32–40, 1986.

    PubMed  CAS  Google Scholar 

  64. Henle, W., and Henle, G. J. Exp. Med. 84:639–660. 1946,

    Article  CAS  Google Scholar 

  65. Mims, C.A. Brit. J. Expt. Path. 41:593–598, 1960.

    CAS  Google Scholar 

  66. Davis, L.E., Cole, L.L., Lockwood, S.J., and Kornfeld, M. Lab. Invest. 48:140–417, 1983.

    PubMed  CAS  Google Scholar 

  67. Davis, L.E., and Kornfeld, M. Am. J. Path. 122:190–192, 1985.

    Google Scholar 

  68. NIH Consensus Conference. JAMA 246:2441–2444. 1981.

    Article  Google Scholar 

  69. Davis, L.E., Green, C.L., and Wallace, J.M. Ann. Neurol. 18:556–559, 1985.

    Article  PubMed  CAS  Google Scholar 

  70. Davis, L.E. Lab. Invest, (in press).

    Google Scholar 

  71. Woodfin, B.M., and Davis, L.E. Biochem. Med. 28:109–114, 1982.

    Article  PubMed  CAS  Google Scholar 

  72. Trauner, D.A., Donoviel, M., and Davis, L.E. Neurol. 33:88, 1983.

    Google Scholar 

  73. Monto, A.S., Ceglarek, J.P., and Hayner, N.S. Amer. J. Epidemiol. 114:750–759, 1981.

    CAS  Google Scholar 

  74. Couch, R.B. In: Reye’s Syndrome IV (Ed. J.D. Pollack), National Reye’s Syndrome Foundation, Bryan, Ohio, 1985, pp. 86–99.

    Google Scholar 

  75. Kerr, A.A., Downham, M.A.P.S., McQuillin, J., and Gardner, P.S. Lancet 1:291–295, 1975.

    Article  PubMed  CAS  Google Scholar 

  76. Wright, P.F., Bryant, J. D., and Karzon, D.T. J. Infect. Dis. 141:430–435, 1980.

    Article  CAS  Google Scholar 

  77. Lichtenstein, P.K., Heubi, J.E., Daugherty, C.C., Farrell, M.K., Sokol, R.J., Rothbaum, R.J., Suchy, F.J., and Balistreri, W.F. N. Engl. J. Med. 309:133–139, 1983.

    Article  CAS  Google Scholar 

  78. Lamontagne, J.R. J. Infect. Dis. 142:452–465, 1980.

    Article  CAS  Google Scholar 

  79. Noble, G.R., Corey, L., and Rubin, R.J. In: Reye’s Syndrome. (Ed. J.D. Pollack), Grune and Stratton, New York, 1975, pp. 189–197.

    Google Scholar 

  80. Partin, J.S., McAdams, A.J., Partin, J.C., Schubert, W.K., McLavrin, R.L. Neuropath. Exp. Neurol. 37:796–819, 1978.

    Article  CAS  Google Scholar 

  81. Norrby, E. J. Gen. Virol. 5:221–236, 1969.

    Article  CAS  Google Scholar 

  82. Boudin, M.-L., Moncany, M., D’Halluin, J.-C., and Boulanger, P.A. Virol. 92:125–138, 1979.

    Article  CAS  Google Scholar 

  83. Rowe, W.P., Hartley, J.W., Roizman, B., and Levy, H.B. J. Exp. Med. 108:713–729, 1958.

    Article  CAS  Google Scholar 

  84. Pettersson, U., and Hoglund, S. Virol. 39:90–106. 1969.

    Article  CAS  Google Scholar 

  85. Ladisch, S., Lovejoy, F.H., Hierholzer, J.C., Oxman, M.N., Strieder, D., Vawter, G.F., Finer, N., and Moore, M. J. Pediatr. 95:348–355, 1979.

    Article  PubMed  CAS  Google Scholar 

  86. Sweet, C., and Smith H. Microbiol. Rev. 44:303–330. 1980.

    PubMed  CAS  Google Scholar 

  87. Gut, J.P., Anton, M., Bingen, A., Vetter, J.M., and Kirn, A. Lab. Invest. 45:218–228, 1981.

    PubMed  CAS  Google Scholar 

  88. Gut, J.P., Schmitt, S., Bingen, A., Anton, M., and Kirn, A. J. Infect. Dis. 146:594–605, 1982.

    Article  CAS  Google Scholar 

  89. Cooperstock, M.S., Tucker, R.P., and Baublis, J.V. Lancet 1:1272–1274, 1975.

    Article  PubMed  CAS  Google Scholar 

  90. Nolan, J.P., and Camara, D.S. In: Alan R. Liss, Inc., New York, 1985.

    Google Scholar 

  91. Mortimer, E.A., Lepow, M.L. Am. J. Dis. Child. 103:583–590, 1962.

    PubMed  CAS  Google Scholar 

  92. Waldman, R.J., Hall, W.N., McGee, H., and Van Amburg, G. JAMA 247:3089–3094, 1982.

    Article  PubMed  CAS  Google Scholar 

  93. Halpin, T.J., Holtzhauer, F.J., Campbell, R.J., Hall, L.J., Correa-Villasenor, A., Lanese, R., Rice, J., and Hurwitz, E.S. JAMA 248:687–691, 1982.

    Article  PubMed  CAS  Google Scholar 

  94. Starko, K.M., Ray, C.G., Dominguez, L.B., Stromberg, W.L., and Woodall, D.F. Pediatr. 66:859–864, 1980.

    CAS  Google Scholar 

  95. Hurwitz, E.S., Barrett, M.J., Bregman, D., Gunn, W.J., Schonberger, L.B., Fairweather, W.R., Drage, J.S., Lamontagne, J.R., Kaslow, R.A., Burlington, D.B., Quinnan, G.V., Parker, R.A., Phillips, K., Pinsky, P., Dayton, D., and Dowdle, W.R. N. Engl. J. Med. 313:849–857, 1985.

    Article  CAS  Google Scholar 

  96. Kaplan, E.H., Kennedy, J., and Davis, J. Arch, Biochem. Biophys. 51:47–61, 1954.

    Article  CAS  Google Scholar 

  97. Miyahara, J.T., and Karler, R. Biochem. J. 97:194–198, 1965.

    PubMed  CAS  Google Scholar 

  98. You, K. Science 221:163–165, 1983.

    Article  PubMed  CAS  Google Scholar 

  99. Olson, L.C., Bourgeois, C.H., Cotton, R.B., Harikul, S., Grossman, R.A. and Smith, T. J. Pediatr. 47:707–716, 1971.

    CAS  Google Scholar 

  100. Nelson, D.B., Kimbrough, R., Landrigan, P.S., Hayes, A.W., Yang, G.C., and Benanides, J. Pediatr. 66:865–869, 1980.

    CAS  Google Scholar 

  101. Rogan, W.J., Yang, G.C., and Kimbrough, R.D. Arch. Environ. Helath 40:91–95, 1985.

    CAS  Google Scholar 

  102. Rogers, A.E. In: Reye’s Syndrome (Ed., J. Dennis Pollack), Grune and Stratton, New York, 1975, pp. 135–145.

    Google Scholar 

  103. Spitzer, W.O. Clin. Invest. Med. 5:203–214, 1982.

    PubMed  CAS  Google Scholar 

  104. Connolly, J.H., Aller, I.V., and Hurwitz, L.J. Lancet 1:542–544, 1967.

    Article  PubMed  CAS  Google Scholar 

  105. Griffin, D.E., Mullinix, J., Narayan, O., and Johnson, R.T. Infect. Immun. 9:690–695, 1974.

    PubMed  CAS  Google Scholar 

  106. Herndon, R.M., Rena-Descalzi, L., Griffin, D.E., and Coyle, P.K. Lab. Invest. 33:544–553, 1975.

    PubMed  CAS  Google Scholar 

  107. Franklin, R.M., and Breitenfeld, P.M. Virol. 8:293–307, 1959.

    Article  CAS  Google Scholar 

  108. Fraser, K.B. Virol. 8:544–546, 1959.

    Article  CAS  Google Scholar 

  109. Bosch, F.X., Hay, A.J., and Skehel, J.J. In:Negative Strand Viruses and the Host Cell (Eds. B.W.J. Mahy and R.D. Barry), Academic Press, New York, 1978, pp.465–474.

    Google Scholar 

  110. Lohmeyer, J., Talens, L.T., and Klenk, H.-D. J. Gen. Virol. 42:73–88, 1979.

    Article  PubMed  CAS  Google Scholar 

  111. Henle, G., Giradi, A., and Henle, W. J. Exp. Med. 101:25–41, 1955.

    Article  CAS  Google Scholar 

  112. Hillis, W.D., Moffat, M.A.J., and Holtermann, O.A. Acta Path. Microbiol. Scand. 50:419–429, 1960.

    Article  PubMed  CAS  Google Scholar 

  113. Ter Meulen, V., and Love, R. J. Virol. 1:626–639, 1967.

    PubMed  Google Scholar 

  114. Lerner, R.A., and Hodge, L.D. Proc. Natl. Acad. Sci. 64:544–551, 1969.

    Article  PubMed  CAS  Google Scholar 

  115. Schrom, M., and Caliguiri, L.A. In: Genetic Variation Among Influenza Viruses (Ed. D.P. Nayak), Academic Press Inc., New York, 1981, pp. 273–282.

    Google Scholar 

  116. Henle, G. and Henle, W. Science 100:410–411, 1944.

    Article  PubMed  CAS  Google Scholar 

  117. Mims, C.A. Brit. J. Exp. Pathcl. 41:586–592, 1960.

    CAS  Google Scholar 

  118. Evans, C.A., and Rickard, E.R. Proc. Soc. Exp. Med. 58:73–74, 1945.

    CAS  Google Scholar 

  119. Johnson, R.T. and Johnson, K.P. Exp. Molec. Pathol. 10:68–80, 1969.

    Article  Google Scholar 

  120. London, W.T., Fuccillo, D.A., and Sever, J.L. Nature 255:483–484, 1975.

    Article  PubMed  CAS  Google Scholar 

  121. Davenport, F.M. In: Viral Infections of Humans (Ed. A.S. Evans), Plenum Medical Book Company, New York, 1982, pp.373–396.

    Google Scholar 

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Authors and Affiliations

  1. University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

    Larry E. Davis M.D.

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Editors and Affiliations

  1. Department of Neurology, University of Colorado Health Sciences Center, Denver, CO, 80262, USA

    Donald H. Gilden M.D. (Professor and Chairman) (Professor and Chairman)

  2. Department of Neurology, Northwestern University Medical School, Chicago, Illinois, 60611, USA

    Howard L. Lipton M.D. (Professor and Acting Chairman) (Professor and Acting Chairman)

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Davis, L.E. (1988). Influenza Virus and Reye’s Syndrome. In: Gilden, D.H., Lipton, H.L. (eds) Clinical and Molecular Aspects of Neurotropic Virus Infection. Developments in Medical Virology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1675-6_6

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