Herpes Simplex Virus Infections of the Nervous System

  • William G. Stroop
  • J. Richard Baringer
Part of the Developments in Medical Virology book series (DIMV, volume 5)


Herpes simplex viruses are a major cause of recurrent mucocutaneous vesicular diseases and can cause myelitis, aseptic meningitis, ocular disease and encephalitis. In this chapter we review the classification, replication and pathophysiology of herpetic infections. The clinical features of oral-facial, ocular, systemic, and nervous system herpetic infections are described with particular emphasis on the pathogenesis, diagnosis and treatment of encephalitis. We review experimental evidence that indicates that infection of the olfactory pathway is fundamental to establishing the proper conditions for development of encephalitis. The concepts of reactivation of a latent temporal lobe infection and exogenous reinfection of the olfactory pathway as they relate to the development of encephalitis are discussed.


Temporal Lobe Thymidine Kinase Aseptic Meningitis Herpes Simplex Virus Encephalitis Olfactory Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • William G. Stroop
    • 1
    • 2
    • 3
  • J. Richard Baringer
    • 1
    • 2
    • 3
  1. 1.Neurovirology Research Laboratory, Veterans Administration Medical CenterUniversity of Utah Medical SchoolSalt Lake CityUSA
  2. 2.Department of NeurologyUniversity of Utah Medical SchoolSalt Lake CityUSA
  3. 3.Department of PathologyUniversity of Utah Medical SchoolSalt Lake CityUSA

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