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Cyclosporin in the Therapy of Idiopathic Nephrotic Syndrome in Children

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Book cover International Yearbook of Nephrology 1989

Part of the book series: International Yearbooks of Nephrology ((IYNE,volume 1))

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Abstract

Idiopathic nephrotic syndrome, which is the most frequent glomerular disease in children, is defined by the combination of nephrotic syndrome and minimal change glomerular disease, with foot process fusion on electron microscopy. No immunoglobulin or complement fraction deposits are seen on immunofluorescent examination. However, in some cases, diffuse mesangial proliferation or focal and segmental glomerulosclerosis may be seen on light microscopy. In addition, immunofluorescent examination sometimes reveals mesangial immunoglobulin deposits found either in isolation or in association with C1q and/or C3 deposits. The most frequently found immunoglobulin is IgM, leading some authors to consider IgM nephropathy as a disease entity (1). IgA deposits have also been found in some patients (2, 3) as well as granular C3 deposits.

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Authors and Affiliations

  1. Service de Nephrologie Pédiatrique and INSERM U 192, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75015, Paris, France

    P. Niaudet & M. Broyer

Authors
  1. P. Niaudet
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  2. M. Broyer
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Editor information

Editors and Affiliations

  1. University of Naples, Naples, Italy

    Vittorio E. Andreucci

  2. University of California, Los Angeles, School of Medicine, California, USA

    Leon G. Fine

  3. Nihon University, Tokyo, Japan

    Michinobu Hatano

  4. Karolinska Hospital, Stockholm, Sweden

    Carl M. Kjellstrand

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© 1989 Kluwer Academic Publishers

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Niaudet, P., Broyer, M. (1989). Cyclosporin in the Therapy of Idiopathic Nephrotic Syndrome in Children. In: Andreucci, V.E., Fine, L.G., Hatano, M., Kjellstrand, C.M. (eds) International Yearbook of Nephrology 1989. International Yearbooks of Nephrology, vol 1. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1673-2_8

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  • DOI: https://doi.org/10.1007/978-1-4613-1673-2_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8934-0

  • Online ISBN: 978-1-4613-1673-2

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