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Prevention of Prostatic Carcinogenesis — Is it Realistic?

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A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer

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Summary

At present there is no effective therapy for increasing survival to metastatic prostatic cancer. New approaches to this major disease are, therefore, urgently needed. One approach is to study the biology of prostatic carcinogenesis in order to develop a therapeutic modality to prevent the initial development of clinically manifest prostatic cancer. This optimism is based upon the demonstration that prostatic carcinogenesis is a multi-step process which can occur over an extended time period. Due to the extended timeframe required to complete all of the malignant steps required for full transformation of a normal prostatic epithelial cell to cancer, it may be possible to block one of the steps involved in this process. Indeed, based upon international epidemiological data of prostatic cancer incidence and the data on migrant populations, this possibility is both possible and practical. Based upon this data, at least one of the steps in prostatic carcinogenesis is preventable or there would not be a more than 10-fold difference between the high versus low prostatic cancer incidence among various international male populations. Therefore, great effort should be focused upon the experimental study of prostatic carcinogenesis in order to detail the specific steps involved in this process. Once the steps are identified, it should be possible to develop therapeutic methods to block at least one of these steps.

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References

  1. Silverberg, F. Cancer Statistics. Cancer 32:15–35, 1982.

    CAS  Google Scholar 

  2. Seidman, H., Silverberg, E. and Bodden, A. Probabilities of eventually developing and dying of cancer (risk among persons previously undiagnosed with cancer). CA - Cancer Journal Clinics 28:33–46, 1978.

    Article  CAS  Google Scholar 

  3. Mettlin, C. Epidemiology of prostate cancer in different population groups. Clin. Oncol. 2:287–300, 1983.

    Google Scholar 

  4. Young, J.L., Percey, C.L. and Asire, A.J. Surveillance, epidemiology and end results: Incidence and mortality data, 1973–1977. National Cancer Institute Monograph 57, DHHS Publication No. (NIH) 81–2330, 1981.

    Google Scholar 

  5. Devesa, S.S. and Silverman, D.T. Cancer incidence and morbidity trends in the United States: 1935–1974. J. Natl. Cancer Inst. 60:545–571, 1978.

    PubMed  CAS  Google Scholar 

  6. Scott, W.W., Menon, M. and Walsh, P.C. Hormonal therapy of prostatic cancer. Cancer (45)1929–1936, 1980.

    Google Scholar 

  7. The Leuprolide Study Group. Leuprolide versus diethylstilbestrol for metastatic prostatic cancer. New Engl. J. Med. 311:1281–1286, 1984.

    Article  Google Scholar 

  8. Menon, M. and Walsh, P.C. Hormonal therapy for prostatic cancer, in: “Prostatic Cancer”, Murphy, G.P. ed., PSG Publishing Co., Littleton, Mass., 1979.

    Google Scholar 

  9. Lepor, H., Ross, A. and Walsh, P.C. The influence of hormonal therapy on survival of men with advanced prostatic cancer. J. Urol. 128:335–340, 1982.

    PubMed  CAS  Google Scholar 

  10. Segi, M. and Karihara, M. Cancer mortality for selected sites in 24 countries, No. 6 (1966–1967). Japanese Cancer Society, p. 81, 1972.

    Google Scholar 

  11. Rotkin, I.D. Epidemiologic factors associated with prostatic cancer, in: “Prostate Cancer. A Series of Workshops on the Biology of Human Cancer”, D.S. Coffey and J.T. Isaacs, eds., Report No. 9, UICC Technical Report Series, 48:56–80, 1979.

    Google Scholar 

  12. Haenszel, W. and Kurihara, M. Studies of Japanese migrants. I. Mortality from cancer and other diseases among Japanese in the United States. J. Natl. Cancer Inst. 40:43–68, 1965.

    Google Scholar 

  13. Staszewski, J. and Haenszel, W. Cancer mortality among the Polish-born in the United States. J. Natl. Cancer Inst. 35:291–297, 1965.

    PubMed  CAS  Google Scholar 

  14. Kastendieck, H. Correlation between atypical primary hyperplasia and carcinoma of the prostate. Histologic studies on 180 total prostatectomies due to manifest carcinoma. Pathology, Research, and Practice 169:366–387, 1980.

    CAS  Google Scholar 

  15. Harbitz, T.B. and Haugen, O.A. Histology of the prostate in elderly men. Acta Pathol, et Microbiol. Scand., Section A 80:756–768, 1972.

    CAS  Google Scholar 

  16. Helpap, B. The biological significance of atypical hyperplasia of the prostate. Virchows Arch. A. Pathol, and Histol. 387:307- 317, 1980.

    Article  CAS  Google Scholar 

  17. Brawn, P.N. Adenosis of the prostate: A dysplastic lesion that can be combined with prostatic adenocarcinoma. Cancer 49:826–833, 1982.

    Article  PubMed  CAS  Google Scholar 

  18. McNeal, J.E. Morphogenesis of prostatic carcinoma. Cancer 18:1659–1666, 1965.

    Article  PubMed  CAS  Google Scholar 

  19. McNeal, J.E. Origin and development of carcinoma in the prostate. Cancer 23:24–34, 1969.

    Article  PubMed  CAS  Google Scholar 

  20. Altenaehr, E., Kastendieck, H. and Siefert, H. Koinzidenz von prostatacarcinom und dysplasie bei totalen prostatektomien und bei autopsien. Verhandlungen der Deutschen Gesellschaft fur Pathologie 63:415, 1979.

    Google Scholar 

  21. Byar, D.P. and Mostofi, F.K. Carcinoma of the prostate: Prognostic evaluation of certain pathological features in 208 radical prostatectomies, examined by the step section technique. Cancer 30:5–13, 1972.

    Article  PubMed  CAS  Google Scholar 

  22. Isaacs, J.T. The aging ACI/Seg versus Copenhagen male rat as a model for the study of prostatic carcinogenesis. Cancer Res. 44:5785–5796, 1984.

    PubMed  CAS  Google Scholar 

  23. Rich, A.P. On the frequency of occurrence of occult carcinoma of the prostate. J. Urol. 33:215–223, 1935.

    Google Scholar 

  24. Moore, R.A. The morphology of small prostatic carcinoma. J. Urol. 33:224–234, 1935.

    Google Scholar 

  25. Franks, L.M. Latent carcinoma of the prostate. J. Pathol. Bacterid. 68:603–616, 1954.

    Article  CAS  Google Scholar 

  26. Sheldon, C.A., Williams, R.D. and Trawley, E.E. Incidental carcinoma of the prostate: A review of the literature and critical reappraisal of classification. J.Urol. 124:626–631, 1980.

    PubMed  CAS  Google Scholar 

  27. Cantrell, B.B., DeKlerk, D.P., Eggleston, J.C.,Boitnott, J. K. and Walsh, P.C. Pathological factors that influence prognosis in Stage A prostatic cancer: The influence of extent versus grade. J. Urol. 125:516–520, 1981.

    PubMed  CAS  Google Scholar 

  28. Ashley, D.J. On the incidence of carcinoma of the prostate J. Pathol. Bacteriol. 90:217–224, 1965.

    Article  PubMed  CAS  Google Scholar 

  29. Breslow, N., Chan, C., Dhom, G., Drury, R., Franks, L.M., Geller, B., Lee, Y., Lundberg, S., Sparke, B., Stemby, N. and Tulinius, H. Latent carcinoma of the prostate at autopsy in seven areas. Int. J. Cancer 10:680–688, 1977.

    Google Scholar 

  30. Waterhouse, J., Muir, C.S., Correa, P. and Powell, J., eds.,Cancer Incidence in Five Continents, Vol. 3, Lyon, IARC 1976.

    Google Scholar 

  31. Huggins, C. and Johnson, M.A. Carcinoma of the bladder and prostate. JAMA 135:1146–1152, 1947.

    CAS  Google Scholar 

  32. Akazaki, K. and Stemmerman, G.N. Comparative study of latent carcinoma of the prostate among Japanese in Japan and Hawaii. J. Natl. Cancer Inst. 50:1137–1144, 1973.

    PubMed  CAS  Google Scholar 

  33. Isaacs, J.T. Prostatic structure and function in relation to the etiology of prostatic cancer. The Prostate 4:351–366, 1983.

    Article  PubMed  CAS  Google Scholar 

  34. Isaacs, J.T. Development and characteristics of the available animal model systems for the study of prostatic cancer, in: “Current Concepts and Approaches to the Study of Prostate Cancer”, D.S. Coffey, N. Bruchovsky, W.A. Gardner, Jr., M.I. Resnick and J.P. Karr, eds., Alan R. Liss, Inc., New York, 1987.

    Google Scholar 

  35. Shain, S.A., McCullough, B. and Segaloff, A. Spontaneous adenocarcinoma of the ventral prostate of aged AXC rats. J. Natl. Cancer Inst. 55:177–180, 1975.

    PubMed  CAS  Google Scholar 

  36. Shain, S.A., McCullough, B. and Nitchuk, W.N. Primary and transplantable adenocarcinomas of the AXC rat ventral prostate gland: Morphologic characterization-tion and examination of C19-steroid metabolism of early-passage tumors. J. Natl. Cancer Inst. 62:313–322, 1979.

    PubMed  CAS  Google Scholar 

  37. Ward, J.M., Reznik, G., Stinson, G.F., Lattuada, C.P., Longfellow, D.S. and Cameron, T.P. Histogenesis and morphology of naturally occurring prostatic carcinoma in the ACI/Seg Hap BR rat. Lab. Invest. 43:517–522, 1980.

    PubMed  CAS  Google Scholar 

  38. Noble, R.L. and Hoover, L. The classification of transplantable tumors in Nb rats controlled by estrogen from dormancy to autonomy. Cancer Res. 35:2935–2940, 1975.

    PubMed  CAS  Google Scholar 

  39. Noble, R.L. The development of prostatic adenocarcinoma in the Nb rat following prolonged sex hormone administration. Cancer Res. 37:1929–1933, 1977.

    PubMed  CAS  Google Scholar 

  40. Drago, J.R. The induction of Nb rat prostatic carcinomas. Anticancer Res. 4:255–256, 1984.

    PubMed  CAS  Google Scholar 

  41. Pollard, M., Luckert, P.H. and Schmidt, M.A. Induction of prostatic adenocarcinomas in Lobund-Wistar rats by testosterone. The Prostate 3:563–568, 1982.

    Article  PubMed  CAS  Google Scholar 

  42. Pollard, M. and Luckert, P.A. Promotional effects of testosterone and dietary fat on prostatic carcinogenesis in genetically susceptible rats. The Prostate 6:1–6, 1985.

    Article  PubMed  CAS  Google Scholar 

  43. Pollard, M. and Luckert, P.H. Production of autochthmous prostate cancer in Lobund-Wistar rats by treatment with N-nitroso-N- methylurea and testosterone. J. Natl. Cancer Inst. 77:538–589, 1986.

    Google Scholar 

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Authors and Affiliations

  1. The Oncology Center and Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    John T. Isaacs Ph.D.

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  1. John T. Isaacs Ph.D.
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Editors and Affiliations

  1. Johns Hopkins University and Hospital, Baltimore, Maryland, USA

    Donald S. Coffey

  2. University Hospitals of Cleveland, Cleveland, Ohio, USA

    Martin I. Resnick

  3. National Cancer Institute, Bethesda, Maryland, USA

    F. Andrew Dorr

  4. Roswell Park Memorial Institute, Buffalo, New York, USA

    James P. Karr

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© 1988 Plenum Press, New York

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Isaacs, J.T. (1988). Prevention of Prostatic Carcinogenesis — Is it Realistic?. In: Coffey, D.S., Resnick, M.I., Dorr, F.A., Karr, J.P. (eds) A Multidisciplinary Analysis of Controversies in the Management of Prostate Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1667-1_4

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  • DOI: https://doi.org/10.1007/978-1-4613-1667-1_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8925-8

  • Online ISBN: 978-1-4613-1667-1

  • eBook Packages: Springer Book Archive

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