A Randomized Prospective Evaluation of Leuprolide versus Diethylstilbestrol in the Treatment of Stage D2 Metastatic Prostate Cancer: Results of a Multicenter Study
For the past 40 years since the observation by Huggins and Hodges that surgical castration or diethylstilbestrol (DES) could bring relief of symptoms from metastatic prostate cancer, these have been the standard therapies for the initial treatment of that disease (1,2). However, during that time the search for less toxic and more acceptable forms of therapy has continued.
KeywordsAcid Phosphatase Bone Pain Metastatic Prostate Cancer LHRH Agonist Hormonal Manipulation
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