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The Molecular Immunology of Complex Carbohydrates pp 153–186Cite as

Interaction of Viruses, Bacteria and Bacterial Toxins with Host Cell Surface Glycolipids. Aspects on Receptor Identification and Dissection of Binding Epitopes

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 228))

Abstract

Specific attachment of viruses and bacteria to carbohydrate has long been known, although it is only recently that the subject is being treated more extensively. The work of Burnet and co-workers in the 1940’s revealed an enzyme activity, “receptor destroying enzyme”, RDE, responsible for specific inhibition of influenza virus binding to cell surfaces.1 Later, Faillard in Klenk’s laboratory identified the substance being split off as NeuAc.2 At about the same time it was shown that several bacte specifically recognized Man.3 About 15 years after, van Heyningen and co-workers opened up4 an intense period of studies on the NecAc containing glycolipid, the ganglioside GM1, as a specific receptor for cholera toxin.5 Concerning glycolipid receptors**, Haywood demonstrated6 a specific binding of Sendai virus to liposomes containing brain gangliosides. Since then, its specificity and biological relevance have been further investigated.7, 8 More recently, two independent groups9, 10 demonstrated a specific binding of E. coli to Galα1→4Gal- containing glycolipids causing urinary tract infection of man. This result was the impetus for a more systematic study of glycolipids as receptors for viruses and bacteria as is now being performed in our laboratory. Recent reviews summarize the receptor knowledge in the case of viruses,11 bacteria12 and bacterial toxins.5

Authors appear in alphabetical order

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References

  1. Burnet, F.M. and Stone, J.D. (1947) The receptor-destroying enzyme of Vibrio cholerae, Austr. J. Exp. Biol. Med. Sci., 25:227–233.

    Article  CAS  Google Scholar 

  2. Faillard, H. (1957) Uber die Abspaltung von N-Acetylneur- aminsáure aus Mucinen durch das “Receptor-Destroying- Enzyme” aus Vibrio cholerae, Z. Physiol. Chem., 307:62–86.

    Article  CAS  Google Scholar 

  3. Collier, W.A. and DeMiranda, J.C. (1955) Bakterien-Hämag-glutination. III. Die Hemmung der Coli-Hámagglutination durch Mannose, Antonie van Leeuwenhoek J. Microbiol. Serol., 21:135–188.

    Google Scholar 

  4. van Heyningen, W.E., Carpenter, C.C.J., Pierce, N.F. and Greenough, W.B. (1971) Deactivation of cholera toxin by ganglioside, J. Infect. Dis., 124:415–418.

    Article  PubMed  Google Scholar 

  5. Eidels, L., Proia, R.L. and Hart, D. A. (1983) Membrane receptors for bacterial toxins, Microbiol. Rev. 47:596–620.

    PubMed  CAS  Google Scholar 

  6. Haywood, A. M. (1974) Characteristics of Sendai virus receptors in a model membrane, J. Mol. Biol., 83:427–436.

    Article  PubMed  CAS  Google Scholar 

  7. Holmgren, J., Svennerholm, L., Elwing, H., Fredman, P. and Stránnegard, Ö. (1980) Sendai virus receptor: Proposed recognition structure based on binding to plastic-adsorbed gangliosides, Proc. Natl. Acad. Sci. USA, 77:1947–1950.

    Article  PubMed  CAS  Google Scholar 

  8. Markwell, M.A., Svennerholm, L. and Paulson, J.C. (1981) Specific gangliosides function as host cell receptors for Sendai virus, Proc. Natl. Acad. Sci. USA, 78:5406–5410.

    Article  PubMed  CAS  Google Scholar 

  9. Källenius, G., Möllby, R., Svenson, S.B., Winberg, J., Lundblad, A., Svensson, S. and Cedergren, B. (1980) The pk antigen as receptor for the haemagglutinin of pyelonephritic Escherichia coli FEMS Microbiol. Lett., 7:297–302.

    Article  Google Scholar 

  10. Leffler, H. and Svanborg Edén, C. (1980) Chemical identi fication of a glycosphingolipid receptor for Escherichia coli attaching to human erythrocytes, FEMS Microbiol. Lett., 8:127–134.

    Article  CAS  Google Scholar 

  11. Dimmock, N.J. (1982) Initial stages in infection with animal viruses, J. Gen. Virol., 59:1–22.

    Article  PubMed  CAS  Google Scholar 

  12. Jones, G.W. and Isaacson, R.E. (1983) Proteinaceous bacterial adhesins and their receptors, CRC Crit. Rev. Microbiol., 10:229–260.

    Article  CAS  Google Scholar 

  13. Lund, B., Lindberg, F.P., Bága, M. and Normark, S. (1985) Globoside-specific adhesins of uropathogenicEscherichia coli are encoded by similar trans-complementable gene clusters, J. Bacterid., 162:1293–1301.

    CAS  Google Scholar 

  14. Wilson, I.A., Skehel, J.J. and Wiley, D.C. (1981) Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3Å resolution, Nature, 289: 366–373.

    Article  PubMed  CAS  Google Scholar 

  15. Rogers, G.N., Paulson, J.C., Daniels, R.S. Skehel, J.J., Wilson, I.A. and Wiley, D.C. (1983) Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity, Nature, 304:76–68.

    Article  PubMed  CAS  Google Scholar 

  16. Sabesan, S., Bock, K. and Paulson, J.C. (1985) Synthesis of sialyloligosaccharides and the determination of their conformational properties based on HSEA calculations and nuclear magnetic resonance spectroscopy, in: “Glyco- conjugates”, E.A. Davidson, J.C. Williams and N.M. Di Ferrante, eds., Praeger Publishers, New York.

    Google Scholar 

  17. Quiocho, F.A. and Vyas, N.K. (1984) Novel sterospecificity of the L-arabinose-binding protein, Nature, 310:381–386.

    Article  PubMed  CAS  Google Scholar 

  18. Berger, E.G., Buddecke, E., Kamerling, J.P., Kobata, A., Paulson, J.Q. and Vliegenthart, J.F.G. (1982) Structure, biosynthesis and functions of glycoprotein glycans, Experientia, 38: 1129–1162.

    Article  PubMed  CAS  Google Scholar 

  19. Hakomori, S.–i. (1983) Chemistry of Glycosphingolipids, in: “Sphingolipid Biochemistry”, J. Kanfer and S.-i Hakomori, eds. Plenum Press, New York.

    Google Scholar 

  20. Höök, M., Kjellen, L. Johansson, S. and Robinson, J. (1984) Cell-surface glycosaminoglycans, Ann. Rev. Biochem., 53:847–869.

    Article  PubMed  Google Scholar 

  21. Podolsky, D.K. (1985) Oligosaccharide structures of human colonic mucin, J. Biol. Chem.,260: 8262–8271.

    PubMed  CAS  Google Scholar 

  22. Hascall, V.C. (1981) Proteoglycans: Structure and function, in: “Biology of Carbohydrates”, Vol. 1, V. Ginsburg and P. Robbins, eds., John Wiley and Sons, New York.

    Google Scholar 

  23. Karlsson, K.-A. (1982) Glycosphingolipids and surface membranes, in: “Biological Membranes”, Vol. 4, D. Chapman, ed., Academic Press, London.

    Google Scholar 

  24. Björk, S., Breimer, M.E., Hansson, G.C., Karlsson, K.–A., Larson, G. and Leffler, H.(1983) Blood group glycosphingolipids of human gastrointestinal tissues, in: “Red Cell Membrane Glycoconjugates and Related Genetic Markers”, J.P. Cartron, P. Rouger and C. Salmon, eds., Librairie Arnette, Paris.

    Google Scholar 

  25. Breimer, M.E., Hansson, G.C., Karlsson, K.-A. and Leffler, H. (1981) Blood group type glycosphingolipids from the small intestine of different animals analysed by mass spectrometry and thin-layer chromatography. A note on species diversity, J. Biochem., 90:589–609.

    PubMed  CAS  Google Scholar 

  26. Breimer, M.E., Hansson, G.C., Karlsson, K.–A. and Leffler, H. (1982) Glycosphingolipids of rat tissue. Different composition of epithelial and nonepithelial cells of small intestine, J. Biol. Chem., 257:557–568.

    PubMed  CAS  Google Scholar 

  27. White, J., Kielian, M. and Helenius, A. (1983) Membrane fusion proteins of enveloped animal viruses, Quart. Rev. Biophys., 16: 151–195.

    Article  CAS  Google Scholar 

  28. Gahmberg, C.G. (1977) Cell surface proteins: changes during cell growth and malignant transformation, in: “Cell Surface Reviews”, Vol. 3, G. Poste and G.L. Nicolson, eds., North-Holland Publishing Company, Amsterdam.

    Google Scholar 

  29. Gahmberg, C.G. and Hakomori, S.–i. (1975) Surface carbohydrates of hamster fibroblasts. I. Chemical characterization of surface-labeled glycosphingolipids and a ceramide tetrasaccharide specific for transformants. J. Biol. Chem., 250: 2438–2446.

    PubMed  CAS  Google Scholar 

  30. Gahmberg, C.G. and Hakomori, S.–i. (1975) Surface carbohydrates of hamster fibroblasts. II. Interaction of hamster NIL cell surfaces with Ricinus communis lectin and concanavalin A as revealed by surface galactosyl label. J. Biol. Chem., 250: 2447–2451.

    PubMed  CAS  Google Scholar 

  31. Hellström, I., Brankovan, V. and Hellström, K.E., (1985) Strong anti-tumor activities of I3 antibodies to a human melanoma-associated ganglioside, Proc. Natl. Acad. Sci. USA, 82: 14 99–1502.

    Google Scholar 

  32. Lampio, A., Finne, J., Homer D. and Gahmberg, C.G (1984) Exposure of the major human red-cell glycolipid, globo- side, to galactose oxidase, Eur. J. Biochem., 145.: 77–82.

    Article  PubMed  CAS  Google Scholar 

  33. Breimer, M.E., Hansson, G.C., Karlsson, K.–A. Larson, G. and Leffler, H. (1986) Glycosphingolipid composition and surface carbohydrate architecture of epithelial cells of human small intestine including the density of cholera toxin receptor, submitted for publication.

    Google Scholar 

  34. Bell, G.I., Dembo, M. and Bongrand, P. (1984) Cell adhesion: Competition betwen nonspecific repulsion and specific bonding. Biophys. J., 4JL: 1051–1064.

    Article  Google Scholar 

  35. Beachey, E.H. (1980) “Bacterial Adherence”, Receptors and Recognition, series B, Vol. 6, Chapman and Hall, London.

    Google Scholar 

  36. Lonberg-Holm, K. and Philipson, L. (1981) “Virus Receptors. Part 2. Animal Viruses”, Receptors and Recognition, Series B, Vol.8, Chapman and Hall, London.

    Google Scholar 

  37. Loomes, L.M., Uemura, K.–i., Childs, R.A., Paulson, J.C., Rogers, G.N., Scudder, P.R., Michalski, J.–C., Hounsell, E.F., Taylor-Robinson, D. and Feizi, T (1984) Erythrocyte receptors for Mycoplasma pneumoniae are sialylated oligosaccharides of the Ii antigen type, Nature, 307:560–563.

    Article  PubMed  CAS  Google Scholar 

  38. Firon, N., Ofek, I. and Sharon, N. (1984) Carbohydrate- binding sites of the mannose-specific fimbrial lectins of Enterobacteria, Infect. Immun. 43:1088–1090.

    PubMed  CAS  Google Scholar 

  39. Lindberg, A.A., Schultz, J.E., Westling, M., Brown, J.E., Rothman, S.W., Karlsson, K.–A. and Strömberg, N. (1986) Identification of the receptor glycolipid for Shiga toxin produced by Shigella dysenteriae type 1, in: “Protein- Carbohydrate Interactions in Biological Systems. The Molecular Biology of Microbial Pathogenicity”, D.L. Lark, ed., Academic Press, pp. 439–446.

    Google Scholar 

  40. Holmgren, J., Elwing, H., Fredman, P., Strannegård, Ö. (1980) Gangliosides as receptors for bacterial toxins and Sendai virus, Adv. Exp. Med. Biol., 125:453–470.

    PubMed  CAS  Google Scholar 

  41. Magnani, J.L., Brockhaus, M., Smith, D.F., Ginsburg, V., Blaszczyk, M., Mitchell, K.F., Steplewski, Z. and Koprowski, H (1981) A monosialoganglioside is a monoclonal antibody- defined antigen of colon carcinoma, Science, 212:55–56.

    Article  PubMed  CAS  Google Scholar 

  42. Hansson, G.C., Karlsson, K.–A., Larson, G., Mibbin, J.M., Blaszczyk, M., Herlyn, M. Steplewski, Z. and Koprowski, H. (1983) Mouse monoclonal antibodies against human cancer cell lines with specificities for blood group and related antigens. Characterization by antibody binding to glycosphingolipids in a chromatogram binding assay, J. Biol. Chem., 258: 4091–4097.

    PubMed  CAS  Google Scholar 

  43. Hansson, G.C., Karlsson, K.–A., Larson, G., Strömberg, N., Thurin, J., Örvell, C. and Norrby, E. (1984) A novel approach to the study of glycolipid receptors for viruses. Binding of Sendai virus to thin-layer chromatograms, FEBS Lett., 170:15–18.

    Article  PubMed  CAS  Google Scholar 

  44. Hansson, G.C., Karlsson, K.–A., Larson, G., Stromberg, N. and Thurin, J. (1985) Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms: a rationalized approach to the study of host cell glycolipid receptors, Anal. Biochem., 146:158–163.

    Article  PubMed  CAS  Google Scholar 

  45. Karlsson, K.–A. and Strömberg, N. (1986) Overlay and solid-phase analysis of glycolipid receptors for bacteria and viruses, Meth. Enzymol., in press.

    Google Scholar 

  46. Bock, K., Breimer, M.E., Brignole, A., Hansson, G.C., Karlsson, K.-A., Larson G., Leffler, H., Samuelsson, B.E., Stromberg, N., Svanborg Eden, C. and Thurin, J. (1985) Specificity of binding of a strain of uropathogenic Escherichia coli to Galα1→4Gal-containing glycosphingo- lipids, J. Biol. Chem., 260:8545–8551.

    PubMed  CAS  Google Scholar 

  47. Holgersson, J., Karlsson, K.–A., Karlsson, P., Norrby, E., Örvell, C. and Strömberg, N. (1985) Approaches to the study of receptors, in: “World’s Debt to Pasteur”, H. Koprowski and S.A. Plotkin, eds., Alan Liss, New York.

    Google Scholar 

  48. Umeda, M., Nojima, S. and Inoue, K. (1984) Activity of human erythrocyte gangliosides as a receptor to HVJ, Virol., 133 172–182.

    Article  CAS  Google Scholar 

  49. Hansson, G.C., Karlsson, K.–A., Larson, G., Lindberg, A.A., Stromberg, N. and Thurin, J. (1983) Lactosylceramide is the probable adhesion site for major indigenous bacteria of the gastrointestinal tract, in: “Glycoconjugates”, M.A. Chester, D. Heinegård, A. Lundblad and S. Svensson, eds., Rahms i Lund, Lund, Sweden.

    Google Scholar 

  50. Magnani, J.L. (1985) Immunostaining free oligosaccharides directly on thin-layer chromatograms, Anal. Biochem., 150:13–17.

    Article  PubMed  CAS  Google Scholar 

  51. Breimer, M.E., Hansson, G.C., Karlsson, K.-A. and Leffler, H. (1983) The preparative separation of sialic acid- containing lipids from sulphate group-containing glycolipids from small intestine of different animals, J. Biochem., 93:1473–1485.

    PubMed  CAS  Google Scholar 

  52. Karlsson, K.–A. (1986) Preparation of total non-acid glycolipids for overlay analysis of receptors for bacteria and viruses and for other studies, Meth. Enzymol., in press.

    Google Scholar 

  53. Karlsson, K.–A. (1973) Carbohydrate composition and sequence analysis of cell surface components by mass spectrometry. Characterization of the major monosialo- ganglioside of brain, FEBS Lett., 32:317–320.

    Article  PubMed  CAS  Google Scholar 

  54. Breimer, M.E., Hansson, G.C., Karlsson, K.-A., Leffler, H., Pimlott, W. and Samuelsson, B.E. (1979) Selected ion monitoring of glycosphingolipid mixtures. Identification of several blood group type glycolipids in the small intestine of an individual rabbit, Biomed. Mass Spectrom., 6: 231–241.

    Article  PubMed  CAS  Google Scholar 

  55. Samuelsson, B.E. (1986) Investigation of the structures of large molecules with special reference to glycoconjugates, Adv. Mass Spectrom., 10: 225–241.

    Google Scholar 

  56. Kushi, Y. and Handa, S. (1985) Direct analysis of lipids on thin-layer plates by matrix-assisted secondary ion mass spectrometry, J. Biochem., 98: 265–268.

    PubMed  CAS  Google Scholar 

  57. Breimer, M.E., Hansson, G.C., Karlsson, K.–A., Leffler, H., Pimlott, W. and Samuelsson, B.E. (1981) Sequencing of oligosaccharides by mass spectrometry applied on a 12- sugar glycolipid, FEBS Let., 124:299–303.

    Article  CAS  Google Scholar 

  58. Dahmén, J., Frejd, T., Grönberg, G., Lave, T., Magnusson, G. and Noori, G (1983) 2-Bromoethylglycosides: applications in the synthesis of spacer-arm glycosides, Carb. Res., 118: 292–301.

    Article  Google Scholar 

  59. Sugita, M., Nakae, H., Yamamura, T., Takamiya, Y., Itasaka, O. and Hori, T. (1985) The occurence of glycosphingo- lipids containing mannose in the sea-water bivalve, Meretrix lusoria (Hamaguri), J. Biochem., 98: 27–34.

    PubMed  CAS  Google Scholar 

  60. Bock, K., Karlsson, K.-A., Strómberg, N. and Tenenberg, S. (1986) Fine dissection of binding epitopes on carbohydrate receptors for microbiological ligands, in: “Protein- Carbohydrate Interaction in Biological Systems. The Molecular Biology of Microbial Pathogenicity”, D.L. Lark, ed., Academic Press, pp. 207–213.

    Google Scholar 

  61. Sabesan, S., Bock, K. and Lemieux, R.U. (1984) The conformational properties of the gangliosides GM2 and GM1 based on 1H and 13C nuclear magnetic resonance studies, Can. J. Chem.,.62: 1034–1045.

    Article  CAS  Google Scholar 

  62. Brown, J.E., Karlsson, K.–A., Lindberg, A., Strómberg, N. and Thurin, J. (1983) Identification of the receptor glycolipid for the toxin of Shigella dysenteriae, in: “Glycoconjugates”, M.A. Chester, D. Heinegárd, A. Lundblad and S. Svensson, eds., Rahms i Lund, Lund, Sweden.

    Google Scholar 

  63. Lemieux, R.U., Wong, T.C., Liao, J. and Kabat E.A. (1984) The combining site of anti-I-Ma (Group 1), Mol. Immunol., 21: 751–759.

    Article  PubMed  CAS  Google Scholar 

  64. Lemieux, R.U., Venot, A.P., Spohr, U., Bird, P., Mandal, G., Morishima, N., Hindsgaul, O. and Bundle, D.R. (1985) Molecular recognition. V. The binding of the B human blood group determinant by hybridoma monoclonal antibodies, Can. J. Chem, 63: 2664–2668.

    Article  CAS  Google Scholar 

  65. Lemieux, R.U. (1985) The hydrated polar—group ‘gate’effect on the specificity and strength of the binding of oligosaccharides by protein receptor sites, manuscript.

    Google Scholar 

  66. Thøgersen, H., Lemieux, R.U., Bock, K. and Meyer, B. (1982) Further justification for the exo-anomeric effect. Conformational analysis based on nuclear magnetic resonance spectroscopy of oligosaccharides, Can. J. Chem., 60: 44–57.

    Article  Google Scholar 

  67. Svensson, S.B., Janson, P.E., Källenius, G., Leontein, K., Óscarson, S., Nilsson, M. and Norberg, T. (1986) Identification, structural and conformational studies of carbohydrate receptor structures in fimbriae mediated binding, in: “Protein-Carbohydrate Interactions in Biological Systems. The Molecular Biology of Microbial Pathogenicity”, D.L. Lark, ed., Academic Press, in press.

    Google Scholar 

  68. Svanborg Edén, C., Freter, R., Hagberg, L., Hull, R., Hull, S., Leffler, H. and Schoolnik, G. (1982) Inhibition of experimental ascending urinary tract infection by an epithelial cell-surface receptor analogue, Nature, 298:560–562.

    Article  Google Scholar 

  69. Källenius, G., Jacobson, S.H., Tullus, K. and Svenson, S.B. (1985) P-fimbriae studies on the diagnosis and prevention of acute pyelonephritis, Infection, 13:159–162.

    Article  PubMed  Google Scholar 

  70. Breimer, M.E., Hansson, G.C. and Leffler, H. (1985) The specific glycosphingolipid composition of human ureteral epithelial cells, J. Biochem., 98:1169–1180.

    PubMed  CAS  Google Scholar 

  71. Iwamori, M., Shimomura, J. and Nagai, Y. (1985) Specific binding of cholera toxin to rat erythrocytes revealed by analysis with a fluorescence-activated cell sorter, J. Biochem., 97: 729–735.

    PubMed  CAS  Google Scholar 

  72. Fishman, P.H., Pacuszka, T., Hom, B. and Moss, J. (1980) Modification of ganglioside GM1. Effect of lipid moiety on choleragen action, J. Biol. Chem., 255:7657–7664.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Organic Chemistry, The Technical University of Denmark, DK-2800, Lyngby, Denmark

    Klaus Bock

  2. Department of Medical Biochemistry, University Göteborg, P.O. Box 33031, S-400 33, Göteborg, Sweden

    Karl-Anders Karlsson, Nicklas Strömberg & Susann Teneberg

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  1. Texas Agricultural Experimental Station, Texas A&M University, College Station, Texas, USA

    Albert M. Wu  & L. Garry Adams  & 

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Bock, K., Karlsson, KA., Strömberg, N., Teneberg, S. (1988). Interaction of Viruses, Bacteria and Bacterial Toxins with Host Cell Surface Glycolipids. Aspects on Receptor Identification and Dissection of Binding Epitopes. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_7

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