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Structural Elucidation of Complex Carbohydrates

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The Molecular Immunology of Complex Carbohydrates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 228))

Abstract

The ability to recognize the chemical markers that distinguish “self” from “foreign” molecules is the first and most important step in the initiation of an immune response. The recognition process essentially involves two components, the antibody/receptor and the antigen. The complete structures of these two components need to be established so that the highly specific process can be understood at the molecular level. In the past decade the application of recombinant DNA technology to dissect the immune system has provided a great deal of insight into the structure and function of antibodies and antigens.

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References

  1. Barber, M., Bordoli, R.S., Sedgwick, R.D. and Tyler, A.N. (1981). Fast Atom Bombardment of Solids as an Ion Source in Mass Spectrometry, Nature, (London) 293, 270–275.

    Article  CAS  Google Scholar 

  2. Carr, S.A. and Reinhold, V.N. (1984). Structural Characterization of Glycosphingolipids by Direct Chemical Ionization Mass Spectrometry, Biomed. Mass Spectrom., ll, 633–642.

    Article  Google Scholar 

  3. Carr, S.A., Reinhold, V.N., Green, B.N. and Hass, J.R. (1985). Enhancement of Structural Information in FAB Ionized Carbohydrate Samples by Neutral Gas Collision. Biomed. Mass Spectrom, 12, 288–295.

    Article  PubMed  CAS  Google Scholar 

  4. Chan, K.W.S. and Cook, R. D. (1983). Factors Affecting Mass Spectral Sensitivity for Ions Sampled by Field Evaporation from a Liquid Matrix, Anal. Chem. 55, 1306–1309

    Article  CAS  Google Scholar 

  5. Cooks, R.G. (1978). Collision Spectroscopy, (e d. R.G. Cooks), Plenum Press, New York, p. 458.

    Google Scholar 

  6. Dell, A. and Ballou, C.E. (1983a). Fast Atom Bombardment, Negative-Ion, Mass Spectrometry of the Mycobacterial O-Methyl-D-Glucose Polysaccharide and Lipopolysaccharides, Carbohydr. Res., l20, 95-lll.

    Article  Google Scholar 

  7. Dell, A. and Ballou, C.E. (1983b). Fast Atom Bombardment Mass Spectrometry of 6–0-Methylglucose polysaccharide, Biomed. Mass Spectrom., 10, 50–56.

    Article  CAS  Google Scholar 

  8. Dell, A., Oates, J., Lugowski, C., Romanowska, E., Kenne, L. and Lindberg, B. (1984). The Enterobacterial Commontigen, A Cyclic Polysaccharide, Carbohydr. Res., 133, 95–104.

    Article  PubMed  CAS  Google Scholar 

  9. Dell, A. and Taylor, G.W. (1983). High-Field Magnet Mass Spectrometry of Biological Molecules, Mass Spectrom. Rev., 3, 357–394.

    Article  Google Scholar 

  10. DeMark B.R. and Klein P.D. (1981). Ammonia gas: An Improved Reagent for Chemical Ionization Mass Spect rometry of Bile Acid Methyl Ester Acetates, J. Lipid Res., 22, 166–177.

    PubMed  CAS  Google Scholar 

  11. Egge, H., Dell, A. and von Nicolai, H. (1 983). Fucose Containing Oligosaccharides from Human Milk. I. Separation and Identification of New Constituents, Arch. Biochem. Biophys., 224, 235–253.

    Article  PubMed  CAS  Google Scholar 

  12. Gower, J. L. (1985). Matrix Compounds for Fast Atom Bombardment Mass Spectrometry, Biomed. Mass Spectrom., 12, 191–196.

    Article  CAS  Google Scholar 

  13. Hanfland, P., Dabrowski, U., Peter-Katalinic, J., Kordowicz, M., Niermann, H., Egge, H., Dabrowski, J. (1983a). Isolation and Characterization of Three Different Blood Group B Active Complex Glycosphingolip ids from Human Eryt hrocyte Membranes, Proc. 7t h Int. Symp.on Glycoconjugates, Lund, S weden, Chester, M.A., Heinegard, D., Lundblad, A., Svensson, S., Ed s.: pp. 411–412.

    Google Scholar 

  14. Hanfland, P., Dabrowski, U., Kordowicz, M., Peteatalinic, J., Dabrowski, J., Egge, H. (1983b). Purification and Structural Elucidation of Th re e Different Blood Group B and I or i Glycosphingolipids from Rabbit Erythrocyte Membranes. Proc. 7th Int. Symp. on Glycoconjugates, L un d, Sweden, Chester, M.A., Heinegard, D., Lundblad, A., Svensson, S., Eds.; pp. 413–414.

    Google Scholar 

  15. Harada, K., Ito, S., Takeda, N., Suzuki, M. and Tatematsu, A. (1983). Sequence Determination of Permethylated Oligosaccharides by Chemical I onization Mass Spectrometry, Biomed. Mass Spectrom., 10, 5–12.

    Article  CAS  Google Scholar 

  16. Harada, K., Ito, S., Suzuki, M. and Iwashita, T. (1983). Structural Investigation o f t he Antibiotic Sporaviridin. VII. Structural Studies on the Constituent Pentasaccharides, Viridopentoses, Cherm. Pharm. Bull. (Japan), 31, 3829–3843.

    CAS  Google Scholar 

  17. Harrison, A.G. (1983). Chemical Ionization Mass SpectrometryCRC Press, Inc., Boca Raton, FL.

    Google Scholar 

  18. Hunt, D.F. (1974). “Reagent Gases for Chemical Ionization Mass Spec trometry,” in Advanc es in Mass Spectrometry(Ed. A. R. West), pp. 143–152. Applied Science Publishers, London.

    Google Scholar 

  19. Jensen, N. J., Tomer, K.B. and Gross, M.L. (1985). Gasphase Ion Decomposition Occurring Remote to a Charged Site, J. Am. Cherm. Soc., 107, 1863–1868.

    Article  CAS  Google Scholar 

  20. Kamerling, J.P., Heerma, W., Vliegenthart, J.F.G., Green, B.N., Lewis, LA.S., Strecker, G. and Spik, G. (1983). Fast Atom Bombardment Mass Spectrometry of Carbohydrate Chains Derived from Glycoproteins, Biomed. Mass Spectrom., 10, 420–425.

    Article  CAS  Google Scholar 

  21. Karlsson, K.-A., Pascher, I., Pimlott, W. and Samuelsson, B.E. (1974). Use of Mass Spectrometry for the Carbohydrate Composition and Sequence Analysis of 2-Hydroxy Fatty Acids, Biomed. Mass Spectrom., l, 49–55.

    Article  PubMed  CAS  Google Scholar 

  22. Keough, T. (1985). Cationization of Organic Molecules Using Fast Atom Bombardment Mass Spectrometry, Anal. Chem., 57, 2027–2034.

    Article  CAS  Google Scholar 

  23. Kondrat, R.W. and Cooks, R. G. (1978) Direct Analysis of Mixtures by Mass Spectrometry, Anal. Cherm., 50, 81A-92A.

    Article  CAS  Google Scholar 

  24. Miller, J. K., Kennedy, E. and Reinhold, V. N. (1986). Osmotic Adaption by Gram-Negative Bacteria: Possible Role for periplasmic Oligosaccharides, Science, 231, 48–51.

    Article  PubMed  CAS  Google Scholar 

  25. Madden, W. H., Schwartz, H. L. and Evans, S. (1976). Direct Analysis of Liquid Chromatographic Effluents, J. Chromatogr., 122, 389–396.

    Article  Google Scholar 

  26. McLafferty, F.W. (1983). Tandem Mass Spectrometry, Wiley-Interscience, New York.

    Google Scholar 

  27. McLafferty, F.W. and Bockhoff, F.M. (1978). Separation/Identification System f or Complex Mixtures Using Mass Separation and Mass Characterization, Anal. Chem., 50, 69–76.

    Article  CAS  Google Scholar 

  28. Munson, B. (1977). Chemical Ionization Mass Spectrometry: Ten Years Later, Anal. Chem., 49, 772A-776A.

    Article  CAS  Google Scholar 

  29. Reinhold, V.N., Coles, E. and Carr, S.A. (1982). New Techniques for Oligosaccharide Sequencing, J. Carbohydr. Chem., 2, 1–18.

    Article  Google Scholar 

  30. Rudewicz, P. and Munson, B. (1985). Neutral Reactions in Gas Chromatography/Chemical Ionization Mass Spectrometry, Anal. Chem., 57, 786–789.

    Article  CAS  Google Scholar 

  31. Santikarn, S., Her, G.-R. and Reinhold, V.N. (1986). Fast Atom Bombardment Mass Spectrometry o f Complex Carbohydrates Desorbed from a Moving Belt. (Manuscript in preparation).

    Google Scholar 

  32. Santikarn, S., Trimble, R.B. and Reinhold, V.N. (1985). Unpublished results.

    Google Scholar 

  33. Stroh, J.G., Cook, J. C., Milberg, R.M., Brayton, L., Kihara, T., Haung, Z. and Rinehart, K.L., Jr. (1985). On-Line Liquid Chromatography/Fast Atom Bombardment Mass Spectrometry, Anal. Chem., 57, 985–991.

    Article  CAS  Google Scholar 

  34. Tabet, J.C. and Fraisse, C. (1981). Reaction. of Cyclohexanone with NH4Ion Under Chemical Ionization Conditions. 1. Formation of Protonated Unsubstituted Imines, Org. Mass Spectrorm., 16, 45–47.

    Article  CAS  Google Scholar 

  35. Van Langenhove, A., and Reinhold, V. N. (1985a). Determination of Polysaccharide Linkage and Branching by Reductive Depolymerization: GC and GC-MS Reference Data, Carbohydr. Res., 140, 1–20.

    Article  Google Scholar 

  36. van der Peyl, G. J.Q., Isa, K., Haverkamp, J. and Kistemaker, P. G. (1981). Gas Phase Ion /Molecule Reactions in Laser Desorption Mass Sp ectrometry, Org. Mass Spectrom., 16, 416–420.

    Article  Google Scholar 

  37. van der Peyl, G.J.Q., van der Zande, W. J., Hoogerbrugge, R. and Kistemaker, P. G. (1985). Kinetic Energy Distributions of Organic Ions Sputtered from Solids and Liquids. Int. J. Mass Spectrom. Ion Proc., 67, 147–159.

    Article  Google Scholar 

  38. Yost, R.A. and Enke, C.G. (1979). Triple Quadrupole Mass Spectrometry for Direct Mixture Analysis and Structural Elucidation, Anal. Chem., 51, 1251A–1264A.

    Article  CAS  Google Scholar 

  39. Yost, R.A. and Fetterolf, D.O. (1983). Tandem Mass Spectrometry (MS/MS). Mass Spectrom. Rev., 2, 1–45.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Nutrition, Harvard School of Public Health, 02115, Boston, Massachusetts, USA

    Vernon N. Reinhold & Sitthivet Santikarn

Authors
  1. Vernon N. Reinhold
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  2. Sitthivet Santikarn
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Editor information

Editors and Affiliations

  1. Texas Agricultural Experimental Station, Texas A&M University, College Station, Texas, USA

    Albert M. Wu  & L. Garry Adams  & 

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© 1988 Plenum Press, New York

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Reinhold, V.N., Santikarn, S. (1988). Structural Elucidation of Complex Carbohydrates. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_31

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  • DOI: https://doi.org/10.1007/978-1-4613-1663-3_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8923-4

  • Online ISBN: 978-1-4613-1663-3

  • eBook Packages: Springer Book Archive

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