N-Glycolylneuraminic Acid-Containing Gangliosides as a Tumor Associated Antigen in Human: Expression of Hanganutziu-Deicher Antigen Active Gangliosides on Human Colon Carcinoma and Melanoma Tissues

  • Yoshio Hirabayashi
  • Makoto Matsumoto
  • Hideyoshi Higashi
  • Shiro Kato
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)


The function of glycosphingolipids on cell surface membranes as “cellular” antigen has recently received much attention. Hanganutziu-Deicher (HD) antigen is an antigen recognized by a human heterophile antibody, HD antibody. Glycosphingolipids containing N-glycolylneuraminic acid (NeuGc) were found to possess HD antigen activity (1). NeuGc is widely distributed in most animals except human and chickens. Recently, the antigen has been found in malignant tissues and sera from patients with various tumors (2, 3). Here we described isolation and characterization of HD antigen-active gangliosides as a tumor associated antigen in human colon carcinoma and melanoma tissues.


Sialic Acid Cell Surface Membrane Melanoma Tissue Sialidase Treatment Antigenic Ganglioside 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Yoshio Hirabayashi
    • 1
  • Makoto Matsumoto
    • 1
  • Hideyoshi Higashi
    • 2
  • Shiro Kato
    • 2
  1. 1.Department of BiochemistryShizuoka College of PharmacyOshika, Shizuoka-shiJapan
  2. 2.Department of PathologyResearch Institute for Microbial Diseases, Osaka UniversitySuita, OsakaJapan

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