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N-Glycolylneuraminic Acid-Containing Gangliosides as a Tumor Associated Antigen in Human: Expression of Hanganutziu-Deicher Antigen Active Gangliosides on Human Colon Carcinoma and Melanoma Tissues

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The Molecular Immunology of Complex Carbohydrates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 228))

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Abstract

The function of glycosphingolipids on cell surface membranes as “cellular” antigen has recently received much attention. Hanganutziu-Deicher (HD) antigen is an antigen recognized by a human heterophile antibody, HD antibody. Glycosphingolipids containing N-glycolylneuraminic acid (NeuGc) were found to possess HD antigen activity (1). NeuGc is widely distributed in most animals except human and chickens. Recently, the antigen has been found in malignant tissues and sera from patients with various tumors (2, 3). Here we described isolation and characterization of HD antigen-active gangliosides as a tumor associated antigen in human colon carcinoma and melanoma tissues.

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References

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Authors and Affiliations

  1. Department of Biochemistry, Shizuoka College of Pharmacy, 422, Oshika, Shizuoka-shi, Japan

    Yoshio Hirabayashi & Makoto Matsumoto

  2. Department of Pathology, Research Institute for Microbial Diseases, Osaka University, 565, Suita, Osaka, Japan

    Hideyoshi Higashi & Shiro Kato

Authors
  1. Yoshio Hirabayashi
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  2. Makoto Matsumoto
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  3. Hideyoshi Higashi
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  4. Shiro Kato
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Editor information

Editors and Affiliations

  1. Texas Agricultural Experimental Station, Texas A&M University, College Station, Texas, USA

    Albert M. Wu  & L. Garry Adams  & 

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© 1988 Plenum Press, New York

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Hirabayashi, Y., Matsumoto, M., Higashi, H., Kato, S. (1988). N-Glycolylneuraminic Acid-Containing Gangliosides as a Tumor Associated Antigen in Human: Expression of Hanganutziu-Deicher Antigen Active Gangliosides on Human Colon Carcinoma and Melanoma Tissues. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_30

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  • DOI: https://doi.org/10.1007/978-1-4613-1663-3_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8923-4

  • Online ISBN: 978-1-4613-1663-3

  • eBook Packages: Springer Book Archive

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