Blood Group Active Haptens in Urine and Faeces

  • Arne Lundblad
  • M. Alan Chester
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)

Abstract

A number of oligosaccharides found in normal urine and faeces have been identified as blood group active haptens, particularly within the ABO and Lewis systems. The oligosaccharide composition in these materials is therefore dependent upon the ABO, H, Lewis and Secretor genotype of the individual.

Keywords

Oligosaccharide Galactose Disaccharide Glycopeptide Fucose 

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References

  1. 1.
    Yosida, K. (1928). Uber die gruppenspezifischen Unterschiede der Transudate, Exsudate, Sekrete, Exkrete, Organextrakte und Organzellen des Menschen und ihre rechtsmedizinischen Anwendungen. Z. ges. explt. Med. 63:331–339.CrossRefGoogle Scholar
  2. 2.
    Freudenberg, K. and Eichel, H. (1935). Uber spezifische Kohlenhydrate der Blutgruppen. Ann. Chem. 518:97–102.Google Scholar
  3. 3.
    Jorpes, E. and Norlin, G. (1934). Uber die blutgruppenmerkmale im Harn des Menschen. Acta path. microbiol. scand. 11:91–118.CrossRefGoogle Scholar
  4. 4.
    Masamune, H., Hakomori, S., Masamune O. and Takase, S. (1956) Biochemical studies on carbohydrates. Group A, B and O substances from human urine. Tohoku. J. Exp. Med. 64:67–80.PubMedCrossRefGoogle Scholar
  5. 5.
    Lundblad, A. and Berggård, I. (1967). Isolation and characterization of urinary A and B agglutinogen fractions. Biochim. Biophys. Acta 148:146–150.PubMedGoogle Scholar
  6. 6.
    Jorpes, E. and Thaning, T. (1945). On the inhomogeneity of the urinary human A-substance. J. Immunol. 51:221–225.PubMedGoogle Scholar
  7. 7.
    Price Evans, D.A., Monnel, R.B. and Donohoe, W.T.A. (1964) Fucose and agglutinogen contents of urine from patients with duodenal ulcers. J. Lab. Clin. Med. 64:581–593.Google Scholar
  8. 8.
    Lundblad, A. (1976). Urinary glycoproteins, glycopeptides and oligosaccharides. In “Mammalian Glycoproteins” (eds. M. Horowitz and W. Pigman). Acad. Press, New York, pp. 441–458.Google Scholar
  9. 9.
    Watkins, W.M. (1966). Blood group specific substances. “Glycoproteins”, ed. Gottschalk, A. Elsevier, Amsterdam pp. 481–483.Google Scholar
  10. 10.
    Hallgren, P. and Lundblad, A. (1977). Structural analysis of urine oligosaccharides isolated from the urine of blood group O, non-secretor woman during pregnancy and lactation. J. Biol. Chem. 252:1014–1022.PubMedGoogle Scholar
  11. 11.
    Hallgren, P. and Lundblad, A. (1977). Structural analysis of oligosaccharides isolated from the urine of a blood group A, secretor woman during pregnancy and lactation. J. Biol. Chem. 252:1023–1033.PubMedGoogle Scholar
  12. 12.
    Hallgren, P., Lindberg, B.S. and Lundblad, A. (1977). Quantitation of some urinary oligosaccharides during pregnancy and lactation. J. Biol. Chem. 252:1034–1040.PubMedGoogle Scholar
  13. 13.
    Lundblad, A., Hallgren, P., Rudmark, A. and Svensson, S. (1973). Structures and serological activities of three oligosaccharides isolated from urines of nonstarved secretors and from secretors on lactose diet. Biochemistry 13:3341–3345.CrossRefGoogle Scholar
  14. 14.
    Chester, M.A., Hallgren, P., Lundblad, A. and Messeter, L. (1979). Urinary oligosaccharide excretion induced by galactose given orally or intravenously. Eur. J. Biochem. 100:385–392.PubMedCrossRefGoogle Scholar
  15. 15.
    Chester, M.A., Hallgren, P., Lindberg, B.S. and Lundblad, A. (1977). Biosynthesis of the blood group B-specific trisaccharide in a Rhesus monkey. Eur. J. Biochem. 77:87–91.PubMedCrossRefGoogle Scholar
  16. 16.
    Björndal, H. and Lundblad, A. (1970). Structure of two urinary oligosaccharides characteristic of blood group O(H) and B-secretors. Biochim. Biophys. Acta 201:434–437.PubMedGoogle Scholar
  17. 17.
    Strecker, G. and Montreuil, J. (1973). Isolement et étude de la structure de 16 oligosaccharides isolés de l urine humaine. C.R. Acad. Sc. Paris 277:1393–1396.Google Scholar
  18. 18.
    Strecker, G., Trentesaux-Chauvet, C., Riazi-Farzad, T., Fournet, B., Bouquelet, S. and Montreuil, J. (1973). Mise en évidence d’une oligosaccharidosurie associée à diverses mélituries et détermination de la structure des oligosaccharides excrétés. Hypothèse concernant l’origine des oligosaccharides des liquides biologiques. C.R. Acad. Sc. Paris 277:1569–1572.Google Scholar
  19. 19.
    Lundblad, A. and Svensson, S. (1973). The structure of a urinary difucosyl pentasaccharide, characteristic of secretors with the blood group A gene. Carbohydr. Res. 30:187–189.PubMedCrossRefGoogle Scholar
  20. 20.
    Derappe, C., Lundblad, A., Messeter, L. and Svensson, S. (1980). Isolation and characterization of a blood group A-specific urinary tetrasaccharide. FEBS Lett. 119:177–180.PubMedCrossRefGoogle Scholar
  21. 21.
    Sabharwal, H., Nilsson, B., Chester, M.A., Sjoblad, S. and Lundblad, A. (1984). Blood group specific oligosaccharides from faeces of a blood group A breast-fed infant. Mol. Immunol. 21:1103–1112.CrossRefGoogle Scholar
  22. 22.
    Sabharwal, H., Nilsson, B., Chester, M.A., Lindh, F., Gronberg, G. and Lundblad, A. (1983). Structures of the main oligosaccharides isolated from faeces of a blood group B, secretor, breast-fed infant. Proc. VIII Int. Symp. Glycoconj. Houston, Texas. 1983.Google Scholar
  23. 23.
    Lundblad, A. and Kabat, E.A. (1971). Immunochemical studies on blood groups. XLVIII Activity of fucose-containing oligosaccharides isolated from human urine and from human ovarian cyst A and B blood group substances. J. Immunol. 106:1372–1577.Google Scholar
  24. 24.
    Furukawa, K., Clausen, H., Hakomori, S., Sakamoto, J., Look, K., Lundblad, A., Mattes, M.J. and Lloyd, K.O. Analyses of the specificity of five murine anti-blood group A monoclonal antibodies, including one that identifies type 3 and type 4 A determinants. Biochemistry, in press.Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Arne Lundblad
    • 1
  • M. Alan Chester
    • 1
  1. 1.Department of Clinical ChemistryUniversity of LundLundSweden

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