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The Chemical Basis for Expression of the Sialyl-Lea Antigen

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The Molecular Immunology of Complex Carbohydrates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 228))

Abstract

Tumor antigens can be defined by antibodies that bind cancer cells and/or their secreted products, but not cells or secreted products of normal tissues from which the cancer cells derive (1,2). Tumor antigens are of interest for three major reasons: (i) they are strategic targets for immunodiagnosis and immunotherapy; (ii) they are potential receptors mediating physiological events that determine cellular organization in tumors; (iii) they are substances produced due to altered biosynthetic control, understanding of which might provide insights into mechanisms for malignant transformation. During the past few years, several laboratories have produced monoclonal antibodies that specifically bind human cancer cells. Many of these recognize complex carbohydrate antigens (3). Such antigens sometimes are present at specific stages of normal embryonic development but disappear completely during later development or persist only in isolated, specialized tissues in the mature organism (4). Carbohydrate tumor antigens probably result from aberrant expression of glycosyltransferases that normally appear and disappear in an orderly and selective fashion according to the genetic program for histologic development and cytodifferentiation (reviewed in 5–7). the sialyl-Lea (SLea) antigen, originally defined by antibody 19–9 (8), occurs during early development in the gastrointestinal tract, but after birth is virtually absent from cells that line the stomach and intentines, persisting only in ducts and secretions of the digestive glands, respiratory tract, and reproductive system (9,10).

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Authors and Affiliations

  1. Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    David Zopf

  2. Department of Medical Biochemistry, University of Gothenburg, P.O. Box 33031, S-400 33, Gothenburg, Sweden

    Gunnar C. Hansson

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  1. David Zopf
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  1. Texas Agricultural Experimental Station, Texas A&M University, College Station, Texas, USA

    Albert M. Wu  & L. Garry Adams  & 

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Zopf, D., Hansson, G.C. (1988). The Chemical Basis for Expression of the Sialyl-Lea Antigen. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_26

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  • DOI: https://doi.org/10.1007/978-1-4613-1663-3_26

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