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The Chemical Basis for Expression of the Sialyl-Lea Antigen

  • David Zopf
  • Gunnar C. Hansson
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)

Abstract

Tumor antigens can be defined by antibodies that bind cancer cells and/or their secreted products, but not cells or secreted products of normal tissues from which the cancer cells derive (1,2). Tumor antigens are of interest for three major reasons: (i) they are strategic targets for immunodiagnosis and immunotherapy; (ii) they are potential receptors mediating physiological events that determine cellular organization in tumors; (iii) they are substances produced due to altered biosynthetic control, understanding of which might provide insights into mechanisms for malignant transformation. During the past few years, several laboratories have produced monoclonal antibodies that specifically bind human cancer cells. Many of these recognize complex carbohydrate antigens (3). Such antigens sometimes are present at specific stages of normal embryonic development but disappear completely during later development or persist only in isolated, specialized tissues in the mature organism (4). Carbohydrate tumor antigens probably result from aberrant expression of glycosyltransferases that normally appear and disappear in an orderly and selective fashion according to the genetic program for histologic development and cytodifferentiation (reviewed in 5–7). the sialyl-Lea (SLea) antigen, originally defined by antibody 19–9 (8), occurs during early development in the gastrointestinal tract, but after birth is virtually absent from cells that line the stomach and intentines, persisting only in ducts and secretions of the digestive glands, respiratory tract, and reproductive system (9,10).

Keywords

Blood Group Human Milk SW1116 Cell Seminal Plasma Blood Group Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David Zopf
    • 1
  • Gunnar C. Hansson
    • 2
  1. 1.Laboratory of PathologyNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Department of Medical BiochemistryUniversity of GothenburgGothenburgSweden

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