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Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated with Tumors

  • Byron Anderson
  • Lyman E. Davis
  • Mario Venegas
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)

Abstract

There are very many glycol ipid and glycoprotein carbohydrate sequences which may be expressed in varying quantities on mammalian cells from different tissues. The types and quantities of the carbohydrate sequences may also vary during the cell cycle, throughout the developmental stages of tissues, during cellular differentiation and in response to extracear signals. The complexity of the carbohydrate sequences is evident and is further emphasized with reports of new sequences in the recent Iiterature. Presumably, all such carbohydrate sequences are available for expression on transformed cells of benign and malignant tissue growths. Transformed cells may make use of this vast repertoire of sequences to maintain their viability in the various environments experienced in their metastatic ventures, to gain a growth advantage, and, in some cases, to maintain a de-differentiated state. Alterations in carbohydrate sequence expression by transformed cells may also allow such cells to escape the host defense mechanisms which would otherwise recognize and react with tumor-specific or -associated carbohydrate (as well as non-carbohydrate) antigenic differences.

Keywords

Blood Group Blood Group Antigen Antibody Reagent Human Blood Group Blood Group Substance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Byron Anderson
    • 1
  • Lyman E. Davis
    • 1
  • Mario Venegas
    • 1
  1. 1.Department of Molecular BiologyNorthwestern University Medical SchoolChicagoUSA

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