Skip to main content
SpringerLink
Log in

Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated with Tumors

  • Chapter
The Molecular Immunology of Complex Carbohydrates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 228))

Abstract

There are very many glycol ipid and glycoprotein carbohydrate sequences which may be expressed in varying quantities on mammalian cells from different tissues. The types and quantities of the carbohydrate sequences may also vary during the cell cycle, throughout the developmental stages of tissues, during cellular differentiation and in response to extracear signals. The complexity of the carbohydrate sequences is evident and is further emphasized with reports of new sequences in the recent Iiterature. Presumably, all such carbohydrate sequences are available for expression on transformed cells of benign and malignant tissue growths. Transformed cells may make use of this vast repertoire of sequences to maintain their viability in the various environments experienced in their metastatic ventures, to gain a growth advantage, and, in some cases, to maintain a de-differentiated state. Alterations in carbohydrate sequence expression by transformed cells may also allow such cells to escape the host defense mechanisms which would otherwise recognize and react with tumor-specific or -associated carbohydrate (as well as non-carbohydrate) antigenic differences.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hakomori, S. (1981) Blood Group ABH and li Antigens of Human Erythrocytes: Chemistry, Polymorphism, and Their Developmental Change, Semln. Hematol. 18: 39–62.

    CAS  Google Scholar 

  2. Lemleux, R. U. (I978) Human Blood Groups and Carbohydrate Chemistry (Hayworth Memorial Lecture), Chem. Soc. Rev.7: 423–427.

    Article  Google Scholar 

  3. Watkins, W. M., Yates A. D. and Greenwel I, P. (1981) Blood Group Antigens and the Enzymes Involved in Their Synthesis: Past and Present. Blochem. Soc. Trans. 9: 186–191.

    CAS  Google Scholar 

  4. Kabat, E. A. (1982) Contributions of Quantitative Immunochem-Istry to Knowledge of Blood Group A, B, H, Le, 1 and 1 Antigens, Am. J. Clin. Pathol. 78: 281–292.

    PubMed  CAS  Google Scholar 

  5. Clausen, H., Levery, S. B., Nudelman, E., Tsuchiya, S. and Hakomori, S. (1985) Repetitive A Epitope (Type 3 Chain A) Defined by Blood Group Apeflc Monoclonal Antibody TH-l: Chemical Basis of Qualitative A1 and A2 Distinction, Proc. Natl. Acad. Scl. USA 82: 1199–1203.

    Article  CAS  Google Scholar 

  6. Clausen, H., Levery, S. B., Kannagl, R. and Hakomori, S. (1986) Novel Blood Group H Glycolipid Antigens Exclusively Expressed in Blood Group A and AB Erythrocytes (Type 3 Chain H), J. Biol, Chem. 261: 1380–1387.

    CAS  Google Scholar 

  7. Gardas, A. and Koscielak, J. (1971) A, B and H Blood Group Specificities in Glycoprotein and Glycolipid Fractions of Human Erythrocyte Membrane. Absence of Blood Group Active Glycoproteins in Membranes of Non-secretors, Vox Sang. 20: 137–149.

    Article  PubMed  CAS  Google Scholar 

  8. Anstee D. J. and Tanner, M. J. A. (1974) The Distribution of Blood-Group Antigens on Butanol Extraction of Human Erythrocyte Ghosts, Biochem. J. 138: 381–386.

    PubMed  CAS  Google Scholar 

  9. Dejter-Juszynski, M, Harpaz, N., Flowers, H. M. and Sharon, N. (1978) Blood-group ABH-Specific Macroycol ipids of Human Erythrocytes: Isolation in High Yield from a Crude Membrane Glycoprotein Fraction, Eur. J. Biochem. 85: 363–373.

    Article  Google Scholar 

  10. Jarnefelt, J., Rush, J., Li, Y. and Laine, R.A. (1978) Ery-throglycan, a High Molecular Weight Glycopeptide With The Repeating Structure (Galactosyl-(l->4)-2-deoxy-2-acetamido-ucos (1->3)1 Comprising More Than One-third Of The Protein-bound Carbohydrate of Human Erythrocyte Stroma, J. Biol. Chem. 253: 8006–8009.

    PubMed  CAS  Google Scholar 

  11. Whittemore, N.B., Trabold, N.C.H., Reed, C. F. and Weed, R. I. (1969) Solubilized Glycoprotein from Human Erythrocyte Membrane Possessing Blood Group A, B and H Activity, Vox Sang. 17: 289–299.

    Article  PubMed  CAS  Google Scholar 

  12. Karhi, K.K. and Gahmberg, C.G. (1980) Identification of Blood Group A-active Glycoproteins in the Human Erythrocyte Membrane, Biochim. Biophys. Acta 622: 344–354.

    CAS  Google Scholar 

  13. Schenkel-Brunner, H. (1980) Blood Group -ABH Antigens of Human Erythrocytes. Quantitative Studies on the Distribution of H Antigenic Sites Among Different Classes of Membrane Components, Eur. J. Biochem. J04: 529–534.

    Article  Google Scholar 

  14. Wilczynska, Z., Mer-Podraza, H. and Koscielak, J. (1980) The Contribution of Different Glycoconjugates to the Total ABH Blood Group Activity of Human Erythrocytes, FEBS Lett. 112: 277–279.

    Article  PubMed  CAS  Google Scholar 

  15. Mehta, N. G. (1980) ABO(H) Blood Group Antigens Of The Human Erythrocyte Membrane: Contribution of Glycoprotein and Glycolipid, J. Membrane Biol. 52: 17–24.

    Article  CAS  Google Scholar 

  16. Coon, J. S. and Weinstein, R. S. (1983) Blood Group Antigens in Tumor Cell Membranes, in Biomembranes -Pathological Membranes, Vol. II, Nowotny A., ed., Plenum Press, New York, pp. 173–205.

    Google Scholar 

  17. Courtney, M., Jallat, S., Tessier, L., Benavente, A., Crystal, R.G. and Lecocq, J. (1985) Synthesis in E. col i of α-Antitrypsin Variants of Therapeutic Potential for Emphysema and Thrombosis, Nature. 313: 149–152.

    Article  PubMed  CAS  Google Scholar 

  18. Bathurst, I. C., Stenflo, J., Errington, D.M. and Carrel I, R.W. Translation and Processing of Normal (Pi MM) and Abnormal (Pi ZZ) Human antitrypsin, FEBS Lett. l53: 270–273.

    Google Scholar 

  19. Foreman, R.C., Judah, J.D. Anolman, A. (1984) Xenopus Oocytes can Synthesize but do not Secrete the Z Variant of Human a]-Antitrypsin. FEBS Lett. I68: 84–88.

    Article  Google Scholar 

  20. Lambert, R.M., Zelenski, S.K. and Kratzel, R.J. (1976) Blood Group Activity in Butanol Extracts of Human Tissues, in: Human Blood Groups 5th Int. Convocation on Immunology, Mohn, F., Plunkett, R.W., Cunningham, R.K., and Lambert, R.M., eds. Karger, Basel, pp. 410–416.

    Google Scholar 

  21. Sakamoto, J., Yin, B.W.T. and Lloyd, K.O. (1984) Analysis of the Expression Of H, Lewis, X, Y and Precursor Blood Group Determinants in Saliva and Red Cells Using a Panel of Mouse Monoclonal Antibodies, Mol. Immunol. 21: 1093–1098.

    Article  PubMed  CAS  Google Scholar 

  22. Koscielak, J., Miller-Podroza, H., Krauze, R. and Piasek, A. (1976) Isolation and Characterization Of Poly(glycosyl) Ceramides (Megaloglycolipids) with A, H, and I Blood-group Activities, Eur. J. Biochem. 71: 9–18.

    Article  PubMed  CAS  Google Scholar 

  23. Sharom, F. J. and Grant, C.W.M. (1978) A Model for Ganglioside Behaviour in Cell Membranes, Biochem. Biophys. Acta 507: 280–293.

    Article  CAS  Google Scholar 

  24. Abdelfattah-Gad, M. and Denk, H. (1980) Epithelial Blood Group Antigens in Human Carcinomas of The Distal Colon: Further Studies on Their Pathologic Significance, J. Natl. Cancer Inst. 64: 1025–1028.

    PubMed  CAS  Google Scholar 

  25. Cooper, H. and Haesler, W.E. (1978) Blood Group Substances as Tumor Antigens in the Distal Colon, Am. J. Clin. Pathol. 69: 594–598.

    PubMed  CAS  Google Scholar 

  26. Denk, H.S., Tappeiner, G., Davidovits, A., Eckerstorfer, R. and Holzner, J.H. (1974) Careinoembryonic Antigen and Blood Group Substances in Carcinomas of the Stomach and Colon, J. Natl. Cancer Inst. 53: 933–942.

    PubMed  CAS  Google Scholar 

  27. Ernst, C., Thurin, J., Atkinson, B., Wurzel, H., Meenhard, H., Stomberg, N., Civin, C. and Koprowski, H. (1984) Monoclonal Antibody Localization of A and B Isoantigens in Normal and Malignant Fixed Human Tissues, Am. J. Pathol. 117: 451–461.

    PubMed  CAS  Google Scholar 

  28. Wiley, E.L., Murphy, P., Mendelsohn, G. and Eggleston, J.C. (1981) Distribution of Blood Group Substances in Normal Human Colon. Use of the Unlabeled Antibody (PAP) Immunoperoxidase Technic to Identify A and B Blood Group Substances, Am. J. Clin. Pathol. 76: 806–809.

    PubMed  CAS  Google Scholar 

  29. Holborow, E.J., Brown, P.C., Glynn, L., Gresham, G.A., O’Brien, T.F. and Coombs, R.R.A. (1960) The Distribution of the Blood-Group A Antigen in Human Tissue, Br. J. Exp. Pathol. 41: 430–437.

    PubMed  CAS  Google Scholar 

  30. Dabelsteen, E., Vedtofte, P., Hakomori, S. and Young, W.W. (1982) Carbohydrate Chains Specific for Blood Group Antigens in Differentiation of Human Oral Epithelium. J. Invest. Derm. 79: 3–7.

    Article  PubMed  CAS  Google Scholar 

  31. Dabelsteen, E., Vedtofte, P., Hakomori, S. and Young, W.W. (1983)Accumulation of a Blood Group Antigen Precursor in Oral Premalignant Lesions, Cancer Res. 43: 1451–1454.

    PubMed  CAS  Google Scholar 

  32. Vedtofte, P., Dabelsteen, E., Hakomori, S. and Young, W.W.(1984) Regional Variations of Cell Surface Carbohydrates in Human Oral Stratified Epithelium, Differentiation 23: 221–228.

    Google Scholar 

  33. Vedtofte, P. (1985) Distribution of Type 1 and 2 Blood Group Chains in Normal and Pathological Odontogenic Epithelium Defined by Monoclonal Antibodies Specific for Le, A and H Type 2, Acta. Path. Microbiol. Immunol. Scand. Sect. A, 93: 265–276.

    CAS  Google Scholar 

  34. Vedtofte, P., Pindborg, J.J. and Hakomori, S. (1985) Relation of Blood Group Carbohydrates to Differentiation Patterns of Normal and Pathological Odontogenic Epithelium, Acta. Path. Microbiol. Immunol. Scand. Sect. A, 93: 25–34.

    CAS  Google Scholar 

  35. Hindsgaul, O., Norberg, T., Le Pendu, J. and Lemieux, R.U. (1982) Synthesis of Type 2 Human Blood Group Antigenic Determinants. The H, X, and Y Haptens and Variations of the H Type 2 Determinant as Probes for the Combining Site of the Lectin I of Ulex europaeus, Carbohydr. Res. 109: 109–142.

    Article  PubMed  CAS  Google Scholar 

  36. Dabelsteen, E. and Fejerskov, 0. (1974) Distribution of Blood Group Antigen A in Human Oral Epithelium, Scand. J. Dent. Res. 82: 206–211.

    PubMed  CAS  Google Scholar 

  37. Coon, J.S. and Weinstein, R.S. (1981) Detection of ABH Tissue Isoantigens by Immunoperoxidase Methods in Normal and Neoplastic Urothelium, Am. J. Clin. Pathol. 76: 163–171.

    PubMed  CAS  Google Scholar 

  38. Bonfiglio, T.A. and Feinberg, M.R. (1976) Isoantigen Loss in Cervical Neoplasia, Arch. Pathol. Lab. Med. 100: 307–310.

    PubMed  CAS  Google Scholar 

  39. Lee, A.K., Delellis, R.A., Rosen, P.P., Saigo, P.E., Gangi, M.D., Bagin, R., Groshen, S. and Wolfe, H.J. (1985) ABH Blood Group Isoantigen Expression in Breast Carcinomas -An Immunohistochemical Evaluation Using Monoclonal Antibodies. Am. J. Clin. Path. 83: 308–319.

    PubMed  CAS  Google Scholar 

  40. Kumazaki, T. and Yoshida, A. (1984) Chemical Evidence that Secretor Gene, Se, is a Structural Gene Encoding a Specific Fuco-sy I transferase, Proc. Natl. Acad. Sci. USA 8J: 4193–4197.

    Article  Google Scholar 

  41. Watkins, W. M. (1980) Biochemistry and Genetics of the ABO, Lewis and P Blood Group Systems, Adv. Hum. Genet J 10: 1–136.

    CAS  Google Scholar 

  42. Le Pendu, J., Lemieux R. U., Lambert F., Dalix, A. M. and Oriol, R. (1982) Distribution of H Type I and Type 2 Antigenic Determinants in Human Sera and Saliva, Am. J. Hum. Genet. 34: 402–415.

    PubMed  Google Scholar 

  43. Oriol, R., Danilovs, J. and Hawkins, B.R. (1981) A New Genetic Model Proposing that the Se Gene is a Structural Gene Closely Linked to the H Gene, Am. J. Hum. Genet. 53: 421–431.

    Google Scholar 

  44. Le Pendu, J., Cartron, J.P., Lemieux, R. U. and Oriol, R. (1985) The Presence of at Least Two Different H-Blood Group-ReIated β-D-Gal α-2-L-Fucos transferases in Human Serum and the Genetics of Blood Group H Substances, Am. J. Hum. Genet. 37: 749–760.

    PubMed  Google Scholar 

  45. Betteridge, A. and Watkins, W. M. (1985) Variant Forms of α-2-L-Fucos transferase in Human Submaxillary Glands from Blood Group ABH “Secretor” and “Non-secretor” Individuals, Glycoconjugate J. 2: 61–78.

    Article  CAS  Google Scholar 

  46. Limas, C. and Lange, P. (1980) Altered Reactivity for A, B, H Antigen in Transitional Cell Carcinomas of the Urinary Bladder. A Study of the Mechanisms Involved, Cancer 46: 1366–1373.

    Article  PubMed  CAS  Google Scholar 

  47. Limas, C. and Lange, P. (1982) A, B, H Antigen Detectability in Normal and Neoplastic Urothelium. Influence of Methodologic Factors. Cancer 49: 2476–2484.

    Article  PubMed  CAS  Google Scholar 

  48. Juhl, B. R. (1985) Semiquantitative Immunohistochemica1 Evaluation of H-Antigen Expression in Human Ureters of Different AB0-and Lewis Types, J. Histochem. Cytochem. 33: 867–874.

    Article  PubMed  CAS  Google Scholar 

  49. Juhl, B.R. (1985) Methodologic and Genetic Influence on Immunohi stochemic Demonstration and Semi quant i tat ion of Blood Group Antigen A in Human Ureter Urothelium, J. Histochem. Cytochem. 33: 21–26.

    Article  PubMed  CAS  Google Scholar 

  50. Vedtofte, P., Hansen, H.E. and Dabelsteen, E. (1981). Distribution of Blood Antigen H in Human Buccal Epithelium of Secretors and Nonsecretors, Scan. J. Dent. Res. 89: 188–195.

    CAS  Google Scholar 

  51. Mollicone, R., Bara, J., Le Pendu, J. and Orio1, R. (1985) Immuno-histologic Pattern of Type 1 (Lea, Leb) and Type 2 (X, Y, H) Blood Group-Related Antigens in the Human Pyloric and Duodenal Mucosae, Lab. Invest. 53: 219–227.

    CAS  Google Scholar 

  52. Sheares, B. T. and Carlson, D.M. (1983) Characterization of UDP-Galactose: 2-Acetamido-2-Deoxy-D-GIucose 3-Beta-Gactosyl-transferase from Pig Trachea, J. Biol. Chem. 258: 9893–9898.

    PubMed  CAS  Google Scholar 

  53. Kannagi, R., Levery, S. B. and Hakomori, S. (1985) Lea-active Heptag Iycosy Iceramide, a Hybrid of Type I and Type 2 Chain, and the Pattern of Glycol ipids with Lea, Leb, X (Lex) and Y (L) Determinants in Human Blood Ceil Membranes (Ghosts), J. Biol. Chem. 260: 6410–6415.

    PubMed  CAS  Google Scholar 

  54. Le Pendu, J., Lemieux, R. U., Dalix, A.M., Lambert, F. and Oriol, R. (1983) Competition Between ABO and Le Gene Specified Enzymes, Vox Sang. 45: 349–358.

    Article  PubMed  Google Scholar 

  55. Johnson, P.H. and Watkins, W. M. (1985) Acceptor Substrate Specificities of Human α-3-and α3,4-L-Fucos transferases, in: Glycoconjugates; Proceedings of the VIII Scientific International Symposium, Davidson, E.A., Williams, J.L. and Derrante, N.M., eds., vol. I, Praeger Scientific, New York, pp. 222–223.

    Google Scholar 

  56. Hansson, G. C. and Zopf, D. (1985) Biosynthesis of the Cancer-Associated Sialy l-Lea Antigen, in: Glycoconjugates -Proceedings of the VI I Ith International Symposium, Davidson E.A., Williams J.C. and Di Ferrante N.M., eds., vol. 2, Praeger Scientific, New York, pp. 554–555.

    Google Scholar 

  57. Brockhaus, M., Wysocka, M., Magnani, J., Steplewski, Z., Koprowski, H. and Ginsburg, V. (1985) Normal Salivary Mucin Contains the Gastrointestinal Cancer-Associated Antigen Detected by Monoclonal Antibody 19–9, in the Serum Mucin of Patients, Vox Sang. 48: 34–38.

    Article  PubMed  CAS  Google Scholar 

  58. Crookston, M. C. (1980) Blood Group Antigens Acquired from the Plasma, in: Immunobiology of the Erythrocyte, Sandler, G.S., Nusbacher, J. and Schamfield, eds., Alan R. Liss, New York, pp. 99–114.

    Google Scholar 

  59. Oriol, R., Danilovs, J., Lemieux, R., Terasaki, P. and Bernoco, D. (1980) Lymphocytotoxic Definition of Combined ABH and Lewis Antigens and their Transfer from Sera to Lymphocytes, Human Immunol. 195–205.

    Google Scholar 

  60. Race, R. R. and Sanger, R. (1975) in: Blood Groups in Man, 6th ed., Blackwell Scientific Publications, Oxford.

    Google Scholar 

  61. Matsukura, Y. (1976) Electron Microscopic Observations on the H Antigen Sites of Human Erythrocytes using Ferritin Antibody Conjugates, Vox Sang. 31: 321–331.

    Article  PubMed  CAS  Google Scholar 

  62. Schachter, H., Michaels, M.A., Tilley, C.A., Crookston, M.C. and Crookston, J.H. (1973) Qualitative Differences in the N-Acet-D-gactosamin transferases Produced by Human A* and A2 Genes, Proc. Natl. Acad. Sci. USA 70: 220–224.

    Article  PubMed  CAS  Google Scholar 

  63. Schachter, H., Michaels, M.A., Crookston, M.C., Tilley, C.A. and Crookston, J.H. (1971) A Quantitative Difference in the Activity of Blood Group A-Specific N-acetylgactosaminy1 transferase in Serum from A1 and A2 Human Subjects, Biochem. Biophys. Res. Commun. 45: 101 1–1018.

    Google Scholar 

  64. Carton, J.P., Ropars, C., Calkovska, Z. and Salmon, C. (1976) Detection of A1 A2 and A1 Am A Heterozygotes Among Human A Blood Group Heterozygotes, J. Immunogenet. 3: 155–161.

    Article  Google Scholar 

  65. Topping, M.D. and Watkins, W. M. (1975) isoelectric Points of the Human Blood Group A1, and A2 and B Gene-Associated Glycosyl-transferases in Ovarian Cyst Fluids and Serum, Biochem. Biophys. Res. Commun. 64:89–96.

    Article  CAS  Google Scholar 

  66. Davidsohn, I. (1972) Early Immunologic Diagnosis and Prognosis of Carcinoma, Am. J. Clin. Path. 57, 715–730.

    PubMed  CAS  Google Scholar 

  67. Davidsohn, I., Kovarik, S. and Lee, C.L. (1966) A, B, and 0 Substances in Gastrointestinal Carcinoma. Arch. Pathol. 81: 381–390.

    PubMed  CAS  Google Scholar 

  68. Dabelsteen, E. (1972) Quantitative Determination of Blood Group Substance A of Oral Epithelial Cells by Immunofluorescence and Immunoperoxidase Methods. Acta. Pathol. Microbiol. Scand. Sect. A, 80: 847–853.

    CAS  Google Scholar 

  69. Thorpe, S.J., Abel, P., Slavin, G. and Feizi, T. (1983) Blood Group Antigens in the Normal and Neoplastic Bladder Epithelium, J. Clin. Pathol. 36: 873–882.

    Article  PubMed  CAS  Google Scholar 

  70. Farr, A.G. and Nakane, P.K. (1981) Immunohistochernistry with Enzyme Labeled Antibodies: A Brief Review, J. Immunol. Methods 47: 129–144.

    Article  PubMed  CAS  Google Scholar 

  71. Sesterhenn, I., Mostofi, F.K. and Davis. C.J. (1984) Immuno-pathology in Prostate and Bladder Tumors, in: Immunocytochemis-try in Tumor Diagnosis, Russo, J., ed., Martinus Nijhoff, Boston, pp. 337–361.

    Google Scholar 

  72. Alroy, J., Ucci, A.A. and Pereira, M.E.A. (1984) Lectins: Histo-chemicalProbes for Specific Carbohydrate Residues, in: Advances in immunohistochernistry, Deleilis, R.A., ed., Masson Publ., New York, pp. 67–88.

    Google Scholar 

  73. Iman, A. and Taylor, C.R. (1985) Application of Immunohisto-chemical Methods in the Diagnosis of Malignant Disease, Cancer Investigation 3: 339–359.

    Article  Google Scholar 

  74. Taylor, C.R. (1983) Immunoenzyme Techniques and Their Application to Diagnostic Studies, Ann. N.Y. Acad. Sci. 420: 115–126.

    Article  PubMed  CAS  Google Scholar 

  75. Mason, D.Y., Abduiaziz, Z., Falini, B. and Stein, H. (1983) Single and Double Immunoenzymatic Techniques for Labeling Tissue Sections with Monoclonal Antibodies, Ann. Acad. Sci. 420: 127–133.

    Article  CAS  Google Scholar 

  76. Hsu, S.M., Raine, L. and Fanger, H. (1981) Use of Avidin-Bio-tin-Peroxidase Complex (ABC) in Immunoperoxidase Techniques: A Comparison Between ABC and Unlabeled Antibody (PAP) Procedures. J. Hi stochern. Cytochem., 29: 577–580.

    Article  CAS  Google Scholar 

  77. Ormanns, W. and Schaffer, R. (1985) An Alkine-Phosphatase Staining Method in Avidin-biotin Immunohistochernistry. Hi stochern. 82: 421–424.

    CAS  Google Scholar 

  78. Bayer, E.A. and Wiichek, M. (1984). The Avidin-Biotin Complex in Immunology, Immunol. Today 5: 39–43.

    Article  Google Scholar 

  79. Stein, H., Gatter, K., Asbahr, H. and Mason, D.Y. (1985) Methods in Laboratory Investigation: Use of Freeze-Dried Paraffin-Em-bedded Sections for Immunohistogic Staining with Monoclonal Antibodies, Lab. Invest. 52: 676–683.

    CAS  Google Scholar 

  80. Taylor, C.R. (1985) Monoclonal Antibodies and ’Routine’ Paraffin Sections, Arch. Pathol. Lab. Med. 109: 115–116.

    Google Scholar 

  81. Weinstein, R.S., Coon, J., Alroy, J. and Davidsohn, I. (1981) Tissue-Associated Blood Group Antigens in Human Tumors, in: Diagnostic Immunohistochernistry, (Dellis, R.A., ed.,) Masson Pub., New York, pp. 239–261.

    Google Scholar 

  82. Chapman, C.M., AMhoff, E.P., Proppe, K.H. and Prout, G.R., Jr.(1983)Use of Monoclonal Antibodies for the Localization of Tissue Isoantigens A and B in Transitional Cell Carcinoma of the Upper Urinary Tract, J. Hi stochern. Cytochem. 31: 557–561.

    Article  CAS  Google Scholar 

  83. Seal, G.M., Rowland, R.G., Thomalla, J.V., Rudolph, R.A., Pfaff, D.S., Kamer, M. and Eble, J.N. (1985) A, B and H Antigens in Normal Urothelium: An Immunohistochernic Study using Monoclonal Antibodies with the Avidin-Biotin Complex Technique, J. Urol. 133: 513–516.

    PubMed  CAS  Google Scholar 

  84. Dabelsteen, E., Buschard, K., Hakomori, S. and Young, W.W. (1984) Pattern of Distribution of Blood Group Antigens on Human Epidermal Cells During Maturation, J. Invest. Dermatol. 82: 13–17.

    Article  PubMed  CAS  Google Scholar 

  85. Horikawa, M., Chisaka, N., Yokoyama, S. and Onoe, T. (1976) Effect of Stirring During Fixation Upon Immunofluorescence. Results with Distribution of Albumin-Producing Cells in Liver, J. Hi stochern. Cytochem. 24: 926–932.

    Article  CAS  Google Scholar 

  86. Larson, L.-L. (1981) Peptide Immunocytochemistry. Prog. Hi stochern. Cytochem. J 3: 1–83.

    Google Scholar 

  87. Coruh, G. and Mason, D.Y. (1980) Serum Proteins in Human Squamous Epithelium, Br. J. Dermatol. 102: 497–505.

    Article  PubMed  CAS  Google Scholar 

  88. Brandtzaeg, P. and Rognum, T.O. (1984) Evaluation of Nine Different Fixatives. 2. Preservation of IgG, lgA and Secretory Component in an Artificial Immunohistochernic Test Substrate, Histochemistry 81: 213–219.

    Article  PubMed  CAS  Google Scholar 

  89. Loeffel, S.C., Gillespie, G. Y. and Mirmiran, S.A. (1985) Cellular Immunol oca Iization of S100 Protein within Fixed Tissue Sections by Monoclonal Antibodies, Arch. Path. Lab. Med. 109: 117–122.

    PubMed  CAS  Google Scholar 

  90. Nemes, Z., Thomazy, V. and Szeifert, G. (1983) Demonstration Of Light Chain Monotypia in B Cell Non-Hodgkins Lymphomas Using Unfixed Freeze-Dried and Formalin-Fixed Trypsinized Paraffin Sections, J. Clin. Pathol. 36: 883–893.

    Article  PubMed  CAS  Google Scholar 

  91. Pankow, M.L., Davis, L.E., Becker, S.P., Ossoff, R.H., and Anderson, B.E. (1984) Use of Dextran and Post-Primary Antibody Fixation in Immunoperoxidase Staining of Fresh Frozen Tissue: Detection of Immunoglobulin Associated with Squamous Carcinomas of the Head and Neck, J. Histochem. Cytochem. 32: 771–777.

    Article  PubMed  CAS  Google Scholar 

  92. Landis, D.M.D. (1985) Promise and Pitfalls in Immunocytochemistry, Trends Neur. Sci. 8: 312–317.

    Article  CAS  Google Scholar 

  93. Taylor, C.R. (1978) Immunoperoxidase Techniques -Practical and Theoretical Aspects, Arch. Pathol. Lab. Med. 102: 113–121.

    PubMed  CAS  Google Scholar 

  94. Petrusz, P. (1983) Essential Requirements for the Validity of Immunocytochemical Staining Procedures, J. Histochem. Cytochem. 31: 177–179.

    Article  PubMed  CAS  Google Scholar 

  95. Thogersen, H., Lemieux, R.U., Bock, K. and Meyer, B. (1982) Further Justification of the Exo-Anomeric Effect: Conformational Analysis Based on Nuclear Magnetic Resonance Spectrosocpy of Oligosaccharides, Can. J. Chem. 60: 44–57.

    Article  Google Scholar 

  96. Marcus, D. M. and Grollman, A. P. (1966) Studies of Blood Group Substances: I. Caprine Precipitating Antisera to Human Lea and Leb Blood Group Substances, J. Immunol. 97: 867–875.

    PubMed  CAS  Google Scholar 

  97. Marr, A.M.S., Donald, A.S.R., Watkins, W. M. and Morgan, W.T.J. (1967) Molecular and Genetic Aspects of Human Blood-Group Leb Specificity, Nature 215: 1345–1349.

    Article  PubMed  CAS  Google Scholar 

  98. Messeter, L., Brodin, T., Chester, M.A., Karlsson, K.A., Zopf, D. and Lundblad, A. (1984) Immunochemical Characterization of a Monoclonal Anti-Leb Blood Grouping Reagent, Vox. Sang. 46: 66–74.

    Article  PubMed  CAS  Google Scholar 

  99. Young, W. W., Johnson, H.S., Tamura, Y., Karlsson, K.A., Larson, G., Parker, J.M.R., Khare, D.P., Spohr, U., Baker, D.A., Hindsgaul, O. and Lemieux R. U. (1983) Characterization of Monoclonal Antibodies Specific for the Lewis a Human Blood Group Determinant, J. Biol. Chem. 258, 4890–4894.

    PubMed  CAS  Google Scholar 

  100. Gooi, H.C., Picard, J.K., Hounsell, E.F., Gregoriou, M., Rees, A.R. and Feizi, T. (1985) Monoclonal Antibody (EGR/649) Reactive with the Epidermal Growth Factor Receptor of A431 Cells Recognizes The Blood Group ALeb and AL Structures, Mo I. Immunol. 22: 689–693.

    Article  CAS  Google Scholar 

  101. Fredman, P., Richert, N.D., Magnani, J.L., Willingham, M.C., Pastan, I. and Ginsburg, V. (1983) A Monoclonal Antibody that Precipitates the Glycoprotein Receptor for Epidermal Growth Factor is Directed Against the Human Blood Group H Type 1 Antigen, J. Biol. Chem. 258: 11206–11210.

    PubMed  CAS  Google Scholar 

  102. Le Pendu, J., Fredman, P., Richter, N.D., Magnani, J.L., Willingham, M.C., Pastan, I., Oriol, R. and Ginsburg, V. (1985) Monoclonal Antibody 101 that Precipitates the Glycoprotein Receptor for Epidermal Growth Factor is Directed Against the Y Antigen, Not the H Type 1 Antigen, Carbohydr. Res. 141: 347–349.

    Article  PubMed  Google Scholar 

  103. Feizi, T. (1985) Demonstration by Monoclonal Antibodies that Carbohydrate Structures of Glycoproteins and Glycolipids are Oncodevelopment Antigens, Nature 314: 53–57.

    Article  PubMed  CAS  Google Scholar 

  104. Hakomori, S. (1984) Tumor-associated Carbohydrate Antigens, Ann. Rev. Immunol. 2: 103–126.

    Article  CAS  Google Scholar 

  105. Lloyd, K.O. (1983) Human Tumor Antigens: Detection and Characterization with Monoclonal Antibodies, in: Basic and Clinical Tumor Immunology, Herberman, R.B., ed., Martinus Nijhoff, Boston, MA, pp. 159–214.

    Google Scholar 

  106. Koprowski, H. (1982) Embryonic Precancerous and Cancerous Human Antigens Recognized by Monoclonal Antibodies, in: Fetal Antigens and Cancer (Ciba Foundation Symposium no. 96) Evered, D. and Whelan, J., eds., Pitman, London, pp. 204–229.

    Google Scholar 

  107. Damjanov, I. and Knowles, B.B. (1984) Monoclonal Antibodies and Tumor-Associated Antigens, in: Advances in the Biology of Disease, Rubin, E. and Danjanor, l., eds. Williams and Wilkins, Baltimore, MD, pp. 181–196.

    Google Scholar 

  108. Kuhns, W.J. and Primus, F.J. (1985) Alterations of Blood Groups and Blood Group Precursors in Cancer, in: Progress in Clinical Biochemistry and Medicine, vol. 2., Springer-Verlag, Berlin, pp. 49–95.

    Google Scholar 

  109. Hakomori, S. and Kannagi, R. (1983) Glycosphingolipids as Tumor-Associated and Differentiation Markers, J. Natl. Cancer Inst. 71: 231–251.

    PubMed  CAS  Google Scholar 

  110. Cowan, W. K. (1962) Blood Group Antigens on Human Gastrointestinal Carcinoma Cells, Br. J. Cancer 16: 535–540.

    Article  PubMed  CAS  Google Scholar 

  111. Davidsohn, l., Ni, L. Y. and Stejskal, R. (1971) Tissue isoan-tigens A, B, and H in Carcinoma of the Stomach, Arch. Pathol. 92: 456–464.

    PubMed  CAS  Google Scholar 

  112. Eklund, A. E., Gullbring, B. and Langerlof, B. (1963) Blood Group Specific Substances in Human Gastric Carcinoma. A Study using the Fluorescent Antibody Technique, Acta. Pathol. Microbiol. Scand. 59: 447–455.

    Article  PubMed  CAS  Google Scholar 

  113. Sheahan, D. G., Horowitz, S. and Zamcheck, N. (1971) Deletion of Epithelial ABH Isoantigens in Primary Gastric Neoplasms and in Metastatic Cancer, Am. J. Dig. Dis. 16: 961–969.

    Article  PubMed  CAS  Google Scholar 

  114. Kay, H.E. M. (1957) A and B Antigens of Normal and Malignant Cells, Br. J. Cancer 11: 409–414.

    Article  PubMed  CAS  Google Scholar 

  115. Lange, P.H., Limas, C. and Fraley, E.E. (1978) Tissue Blood-group Antigens and Prognosis in Low Stage Transitional Ceil Carcinoma of the Bladder, J. Urol. 119: 52–55.

    PubMed  CAS  Google Scholar 

  116. Davidsohn, l., Kovarik, S. and Ni, L.Y. (1969) isoantigens A, B and H in Benign and Malignant Lesions of the Cervix, Arch. Pathol. 87: 306–314.

    PubMed  CAS  Google Scholar 

  117. Davidsohn, I. and Stejskal R. (1972) Tissue Antigens A, B and H in Health and Disease, Haemotologia (Budap) 6: 177–184.

    CAS  Google Scholar 

  118. Gupta, R. K., Schuster, R. and Christian, W. D. (1973). Loss of isoantigens A, B and H in Prostate, Am J. Pathol. 70: 439–447.

    PubMed  CAS  Google Scholar 

  119. Davidsohn, I., Ni, L.Y. and Stejskal, R. (1971) Tissue Isoantigens A, B and H in Carcinoma of the Pancreas. Cancer Res. 31: 1244–1250.

    PubMed  CAS  Google Scholar 

  120. Davidsohn, I. and Ni, L.Y. (1969) Loss of isoantigens A, B and H in Carcinoma of the Lung, Am. J. Pathol. 51: 307–334.

    Google Scholar 

  121. Gupta, R. K. and Schuster, R. (1973) Isoantigens A, B, and H in Benign and Malignant Lesions of Breast, Am. J. Pathol. 72: 253–260.

    PubMed  CAS  Google Scholar 

  122. Liu, P. I., Mregor, D.H. and Liu, J.G. (1974) Carcinoma of the Oral Cavity Evaluated By Specific Red Cell Adherence Test, Oral Surg. 32: 56–64.

    Article  Google Scholar 

  123. Lin, F., Liu, P.I. and Mregor, D.H. (1977) Isoantigens A, B, and H in Morphologically Normal Mucosa and in Carcinoma of the Larynx, Am. J. Clin. Pathol. 68: 1372–376.

    Google Scholar 

  124. Davis, L.E., Pankow, M.L., Sobut, R., Keesara, S. and Anderson, B. (1984) Blood Group (BG) Antigen (Ag) Expression by Normal and Squamous Carcinoma Epithelia, Fed. Proc. 43: 1751.

    Google Scholar 

  125. Fujita, J., Matsumoto, K., Kishi, K. and Ishiyama, I. (1981) Synthesis of ABH Blood Group Substances in Bladder Tumors, Br. J. Urol. 53: 448–452.

    Article  PubMed  CAS  Google Scholar 

  126. Hall, L., Faddoul, A., Saberi, A. and Edson, M. (1982) The Use of the Red Cell Surface Antigen to Predict the Malignant Potential of Transitional Cell Carcinoma of the Ureter and Renal Pelvis, J. Urol. 127: 23–25.

    PubMed  CAS  Google Scholar 

  127. Emmott, R. C., Javadpour, N., Bergman, S. M. and Soares, T. (1979) Correlation of the Ceil Surface Antigens with Stage and Grade in Cancer of the Bladder, J. Urol. 121: 37–39.

    PubMed  CAS  Google Scholar 

  128. Richie, J.P., Blute, R.D. and Waisman, J. (1980) Immunologic Indicators of Prognosis in Bladder Cancer: The Importance of Cell Surface Antigens, J. Urol. 123: 22–24.

    PubMed  CAS  Google Scholar 

  129. Decenzo, J. M., Howard, P. and Irish, C.E. (1975) Antigenic Deletion and Prognosis of Patients with Stage A Transitional Cell Bladder Carcinoma, J. Urol. 114: 874–878.

    PubMed  CAS  Google Scholar 

  130. Newman, A. J., Carlton, C.E. and Johnson, S. (1980) Cell Surface A, B or O (H) Blood Group Antigens as an Indicator of Malignant Potential in Stage A Bladder Cancer, J. Urol. 124: 27–29

    PubMed  Google Scholar 

  131. Bergman, S. and Javadpour, N. (1978) The Cell Surface Antigen A, B or 0 (H) as an Indicator of Malignant Potential in Stage A Bladder Carcinoma: Preliminary Report, J. Urol. 119: 49–51.

    PubMed  CAS  Google Scholar 

  132. Cooper, H.S. and D’Elia, F. L. (1982) Comparison Between the Methods of Indirect Immunofluorescence and Specific Red Cell Adherence in Detecting ABH lso-antigens in Bladder Carcinoma, Am. J. Clin. Pathol. 77: 548–554.

    PubMed  CAS  Google Scholar 

  133. Sträuchen, J.A., Bergman, S.M. and Hanson, T.A.S. (1980) Expression of A and B Tissue Isoantigens in Benign and Malignant Lesions of the Breast, Cancer, 4 5: 2149–2155.

    Article  Google Scholar 

  134. King, C. T., Clark, T.D., Lovett, J., Cash, J.B., Primus, F.J., Moberts, J.W. and Flanigan, R.C. (1983) A Comparison of Clinical Course with Blood Group Antigen Testing by Specific Red Cell Adherence and Immunoperoxidase in Ureteral and Renal Pelvic Tumors, J. Urol. 130: 871–873.

    PubMed  CAS  Google Scholar 

  135. Flanigan, R. C., King, C.T., Clark, T.D., Cash, J.B., Greenfield, B. J., Sniecinski, I.J. and Primus, F.J. (1983) Immuno-histochernic Demonstration of Blood Group Antigens in Neoplastic and Normal Human Urothelium, J. Urol. 130: 499–503.

    PubMed  CAS  Google Scholar 

  136. Von Kleist, S., King, M. and Huet, C. (1980) Evidence for Membrane Bound Antibodies Directed Against Antigens Expressed on Tumors, in: Contempary Topics in Immunobiology, vol. 10, Witz, I.P. and Hanna, Jr., M.G., eds., Plenum Press, New York, pp. 177–189.

    Google Scholar 

  137. Ran, M., Yaakubowicz, M., Amitai, o. and Witz, I.P. (1980) Tumor-1 oczing Lymphocytoxic Antibodies, in: Contemporary Topics in Immunobiology, vol. 10, Witz, I.P. and Hanna, Jr. M.G., eds., Plenum Press, New York, pp. 191–211.

    Google Scholar 

  138. Gupta, R.K. and Morton, D.L. (1985) Clinical Significance and Nature of Circulating Immune Complexes in Melanoma Patients, in: Immune Complexes and Human Cancer, Contemporary Topics in Immunobiology, vol. 15, Salinas, F.A. and Hanna, Jr., M.G., eds., Plenum Press, New York, pp. 1–53.

    Google Scholar 

  139. Salinas, F.A., Wu, K.H. and Silver, H.K. (1985) Clinical Relevance of Immune Complexes, Associated Antigen and Antibody in Cancer, in: Immune Complexes and ’ Human Cancer, Contemporary Topics in Immunobiology, vol. 15, Salinas, F.A. and Hanna, Jr., M.G., eds., Plenum Press, New York, pp. 55–109.

    Google Scholar 

  140. Witz, I.P. (1971) Tumor-Associated Immunoglobulins, Isr. J. Med. Sci. 7: 230–238.

    PubMed  CAS  Google Scholar 

  141. Witz, I.P. (1973). The Biological Significance of Tumor-Bound Immunoglobulins, Curr. Top. Microbiol. Immunol. 61 151–171.

    PubMed  CAS  Google Scholar 

  142. Cruse, J.M. and Azar, M.M. (1967) Immunologic Enhancement Induced by 7S Antibody Globulin, Z. Immun.-Forsch. 132: 240–246.

    CAS  Google Scholar 

  143. Takasugi, M. and Hildemann, W. H. (1969) Regulation of Immunity Toward Allogeneic Tumors in Mice. I. Effect of Antiserum Fractions on Tumor Growth, J. Natl. Cancer Inst. 43: 843–856.

    PubMed  CAS  Google Scholar 

  144. Sjogren, H.O., Heílstrom, I., Bansol, S.C. and Heilstrom, K.E. (I971) Suggestive Evidence that the “Blocking Antibodies” of Tumor-Bearing Individuals May be Antigen-Antibody Complexes, Proc. Natl. Acad. Sci. 68: 1372–1375.

    Article  PubMed  CAS  Google Scholar 

  145. Brandtzaeg, P. (1974) Mucosal and Glandular Distribution of Immunoglobulin Components. Immunohistochemistry With a Cold Ethanol-Fixation Technique, Immunology 26: 1101–1114.

    PubMed  CAS  Google Scholar 

  146. Brandtzaeg, P. and Baklien, K. (1972) Extra-and Intracellular Distribution of Immunoglobulins and Secretory Component in Human Intestinal Mucosa as Revealed by Immunofluorescence, Scand. J. Gastroenterol., Suppl.16: 12–24.

    Google Scholar 

  147. Brandtzaeg, P., Surjan,L., Jr., and Rerdal, P. (1978) Immunoglobulin Systems of Human Tonsils. I. Control Subjects of Various Ages: Quantification of lg-producing Cells, Tonsillar Morphometry and Serum Ig concentrations. Clin. Exp. Immunol. 31: 367–381.

    PubMed  CAS  Google Scholar 

  148. Brandtzaeg, P., Fjefllanger, I. and Gjeruldsen, S.T. (1970) Human Secretory Immunoglobulins. I. Salivary Secretions from Individuals with Normal or Low Levels of Serum Immunoglobulins, Scand. J. Haemat., Suppl. 12: 3–83.

    CAS  Google Scholar 

  149. Quismorio, F.P., Rea, T. H., Levan, N.E. and Friou, G. J. (1975) Immunoglobulin Deposits in Lepromatous Leprosy Skin. Presence of Deposits in Apparently Uninvolved Skin and Occurrence of Serum Antiepitheli Antibodies, Arch. Dermatol. 111: 331–334.

    Article  PubMed  CAS  Google Scholar 

  150. Izsak, F.C., Brenner, H.J., Landes, E., Ran, M. and Witz, I.P. (1974) Correlation Between Clinicopathologica1 Features of Malignant Tumors and Cell Surface Immunoglobulins, Isr. J. Med. Sci. 10: 642–646.

    PubMed  CAS  Google Scholar 

  151. Braslawsky, G. R., Ran, M. and Witz, I.P. (1976) Tumor Bound Immunoglobulins: The Relationship Between the In Vivo Coating of Tumor Cells by Potentially Cytotoxic Anti-Tumor Antibodies, and the Expression of Immune Complex Receptors, Int. J. Cancer 18: 116–121.

    Article  PubMed  CAS  Google Scholar 

  152. Lewis, M.G., Avis, P.J.G., Phillips, T.M. and Sheikh, K.M.A. (1973) Tumor-Associated Antigens in Human Malignant Melanoma, Yale J. Biol. Med. 46: 661–668.

    PubMed  CAS  Google Scholar 

  153. Lewis, M.G., Hartman, D. and Jerry, L.M. (1976) Antibodies and Anti-Antibodies in Human Malignancy: An Expression of Deranged Immune Regulation, Ann. N.Y. Acad. Sci. 276, 316–327.

    Article  PubMed  CAS  Google Scholar 

  154. Gerber, M.A., Koffler, D. and Cohen, C.J. (1977) Circulating Antibodies in Patients with Ovarian Carcinoma, Gynecol. Oncology 5: 228–232.

    CAS  Google Scholar 

  155. Richman, A.V. (1976) Immunofluorescence Studies of Benign and Malignant Human Mammary Tissue, J. Natl. Cancer Inst. 57: 263–267.

    PubMed  CAS  Google Scholar 

  156. Popovic, D., Gill, L., Sisson, G., Applebaum, E. and Anderson, B. (1976). Detection and Localization of Tumor-Associated Immune Components of Head and Neck Squamous Cell Carcinomas, Tr. Am. Acad. Opth. Otol. 82: 119–130.

    CAS  Google Scholar 

  157. Koneval, T., Applebaum, E., Popovic, D., Gilí, L., Sisson, G., Wood, G.W. and Anderson, B. (1977) Demonstration of Immunoglobulin in Tumor and Marginal Tissues of Squamous Cell Carcinomas of the Head and Neck, J. Natl. Cancer Inst. 59: 1089–1097.

    PubMed  CAS  Google Scholar 

  158. Moav, N., Hochberg, Y., Cohen, G. and Witz, I.P. (1978) Binding Patterns of Immunoglobulins from Tumor-Bear ing Mice to the Corresponding Tumor Cells, J. Immunol. Methods 22: 37–49.

    Article  PubMed  CAS  Google Scholar 

  159. Moav, N. and Witz, I.P. (1978) Characterization of Immunoglobulins Eiuted from Murine Tumor Cs: Binding Patterns of Cytotoxic Anti-Tumor I, J. Immunol. Methods 22: 51–62.

    Article  PubMed  CAS  Google Scholar 

  160. Brown, J.P., Klitzman, J.M. and Hellstrom, K.E. (1977) A Mi-croassay for Antibody Binding to Tumor Cel i Surface Antigens Using 125-Labelled protein A from Staphylococcus Aureus, J. Immunoi. Methods 15: 57–66.

    Article  CAS  Google Scholar 

  161. Ting, C. C. (1976) Detection of Anti-Tumor Antibody in Virally Induced Tumors and Its Relationship to Tumor Growth, Int. J. Cancer 18: 205–215.

    Article  PubMed  CAS  Google Scholar 

  162. Wood, G. W. and Barth, R.F. (1974) Jmmunof I uorescent Studies of the Serologic Reactivity of Patients with Malignant Melanoma Against Tumor-Associated Cytoplasmic Antigens, J. Natl. Cancer Inst. 53: 309–316.

    PubMed  CAS  Google Scholar 

  163. Lewis, M.G. and Phillips, T.M. (1972) The Specificity of Surface Membrane Immunofluorescence in Human Malignant Melanoma, Int. J. Cancer 10: 105–111.

    Article  PubMed  CAS  Google Scholar 

  164. Chapuis, B. J., Powles, R. and Alexander, P. (1978) Inability to Demonstrate Lytic Antibodies to Autologous Leukemia Cells in the Sera from Remission Patients with Acute Myogenous Leukaemia Treated with Active Specific Immunotherapy, CI in. Exp. Immunol. 32: 253–258.

    CAS  Google Scholar 

  165. Paluch, E. and loachim, H.L. (1978) Lung Carcinoma-Reactive Antibodies Isolated from Tumor Tissues and Pleural Effusions of Lung Cancer Patients, J. Natl. Cancer Inst. 61: 319–325.

    PubMed  CAS  Google Scholar 

  166. Sheikh, K.M.A., Apuzzo, M.L.J., Kochsiek, K.R. and Weiss, M.H. (1977) Malignant Glial Neoplasms: Definition of a Humoral Host Response to Tumor-Associated Antigen(s), Yale J. Biol. Med. 50: 397–403.

    CAS  Google Scholar 

  167. Gupta, R.K., Irie, R.F. and Morton, D.L. (1978) Antigens on Human Tumor Cells Assayed by Complement Fixation with Allogeneic Sera, Cancer Res. 38: 2573–2580.

    PubMed  CAS  Google Scholar 

  168. Gupta, R.K., Silver, H.K.B., Reisfeld, R.A. and Morton, D.L. (1978) Isolation and Characterization of Antitumor Antibodies from Cancer Patient Sera by Affinity Chromatography. Proc. Am. Assoc. Cancer Res. 19: 133.

    Google Scholar 

  169. Edynak, E.M., Hirshaut, Y., Bernhard, M. and Trempe, G. (1972) Fluorescent Antibody Studies of Human Breast Cancer, J. Natl. Cancer Inst. 48: 1137–1143.

    PubMed  CAS  Google Scholar 

  170. Sofen, H. and O’Toole, C. (1978) Anti-Squamous Tumor Antibodies in Patients with Squamous Cell Carcinoma, Cancer Res. 38: 199–203.

    PubMed  CAS  Google Scholar 

  171. Rosenberg, S. A., Schwarz, S., Anding, H., Hyatt, C. and Williams, G.M. (1977) Comparison of Mtiple Assays for Detecting Human Antibodies Directed Against Surface Antigens on Normal and Malignant Human Tissue Culture Cells. J. Immunol. Methods 17, 225–239.

    Article  PubMed  CAS  Google Scholar 

  172. Boyle, M.D.P., Ohanian, S.H. and Borsos, T. (1976) Lysis of Tumor Cells by Antibody and Complement. VI. Enhanced Killing of Enzyme-Pretreated Tumor Cells, J. Immunol. 116: 661–668.

    PubMed  CAS  Google Scholar 

  173. Nordquist, R.E., Schafer, F.B., Manning, N.E., Ishmael, D.R. and Hoge, A.F. (1977) Antitumor Antibodies in Human Breast Cancer Sera as Detected by Fixed Cell Immunofluorescence and Living Cell Membrane Immunofluorescence Assays, J. Lab. Clin. Med. 89: 257–261.

    PubMed  CAS  Google Scholar 

  174. Lerner, M.P., Anglin, J.H. and Nordquist, R.E. (1978) Cell-Surface Antigens From Human Breast Tumor Cells, J. Natl. Cancer Inst. 60: 39–44.

    PubMed  CAS  Google Scholar 

  175. Springer, G.F., Desai, P.R. and Scanlon, E.F. (1976) Blood Group MN Precursors as Human Breast Carcinoma-Associated Antigens and “Naturally”y Occurring Human Cytotoxins Against Them, Cancer 37: 169–176.

    Article  PubMed  CAS  Google Scholar 

  176. Ferrone, S. and Pellegrino, M.A. (1977) Cytotoxic Antibodies to Cultured Meianoma Cells in the Sera of Melanoma Patients, J. Natl. Cancer Inst. 58: 1201–1204.

    PubMed  CAS  Google Scholar 

  177. Zeltzer, P.M. and Seeger, R.C. (1977) Microassay Using Radio-iodinated Protein A from Staphylococcus Aureus for Antibodies Bound to Cell Surface Antigens of Adherent Tumor Cells, J. Immunol. Methods 17: 163–175.

    Article  PubMed  CAS  Google Scholar 

  178. Hahn, W.V., Kagnoff, M.F. and Hatlen, L.H. (1978) Immune Responses in Human Colon Cancer. II. Cytotoxic Antibody Detected in Patients1 Sera, J. Natl. Cancer Inst. 60: 779–784.

    PubMed  CAS  Google Scholar 

  179. Sloan, T.B., Martincic, R.R. and Anderson, B. (1981) Synovial Cell Antigens -Production of Heterologous Anti-Human Synovial Cell Sera and General Reactivities of the Antisera, Exp. Cell Biol. 49: 20–33.

    PubMed  CAS  Google Scholar 

  180. Sloan, T.B., Martincic, R.R. and Anderson, B. (1981) Synovial Cell Antigens -Differences of Antigen Compositions Between Rheumatoid Arthritic (RA)-and Non-RA-Derived Synovial Cells Detected with Anti-Synovial Cell Sera, Exp. Cell Biol. 49: 195–206.

    PubMed  CAS  Google Scholar 

  181. Sloan, T.B., Martincic, R.R. and Anderson, B. (1981) Differences of Antigen Composition of Rheumatoid Arthritic (RA) and Non-RA Derived Tissue Cultured Synovial Cells as Detected by Monkey Anti-RA Synovial Cell Sera, J. Rheumatol. 8: 204–213.

    PubMed  CAS  Google Scholar 

  182. Oettgen, H.F., Shiku, H., Takahashi, T., Carey, T., Resnick, L., Ueda, R., Pfreundschuh, M. and Old, L.J. (1978) Human Cancer Immunology, in: Brain Metastasis, Weiss, L., Gilbert, H.A. and Posner, J.B., eds., vol. 2, G.K. Hall and Co., Boston, pp. 165–185.

    Google Scholar 

  183. Houghton, A.N., Taormina, M.C., Ikeda, H., Watanabe, T., Oettgen, H.F. and Old, L.J. (1980) Serological Survey of Normal Humans for Natural Antibody to Ceil Surface Antigens of Melanoma, Proc. Natl. Acad. Sci. 77 4260–4264.

    Article  PubMed  CAS  Google Scholar 

  184. Wood, G.W. and Gillespie, G.Y. (1975) Studies on the Role of Macrophages In Regulation of Growth and Metastasis of Murine Chemically Induced Fi brosarcomas, Int. J. Cancer 16: 1022–1029.

    Article  PubMed  CAS  Google Scholar 

  185. Bleiberg, H. and Galand, P. (1976) In Vitro Autoradiographic Determination of Cell Kinetic Parameters in Adenocarcinomas and Adjacent Healthy Mucosa of the Human Colon and Rectum, Cancer Res. 36: 325–328.

    PubMed  CAS  Google Scholar 

  186. Filipe, M.L. (1975) Mucous Secretion in Rat Colonic Mucosa During Carcinogenesis Induced by Dimethhydrazine. A Morphological and Hi stochemic Study, Br. J. Cancer 32: 60–77.

    Article  PubMed  CAS  Google Scholar 

  187. Dawson, P.A. and Filipe, M.L. (1976) An Ultrastructur and Histochemical Study of the Mucous Membrane Adjacent to and Remote From Carcinoma of the Colon, Cancer 37: 2388–2398.

    Article  PubMed  CAS  Google Scholar 

  188. Lipkin, M. (1975) Biology of Large Bowel Cancer: Present Status and Research Frontiers, Cancer36: 2319–2324.

    Article  Google Scholar 

  189. Koutcher, J.A., Goldsmith, M. and Damadion, R. (1978) NMR in Cancer. X. A Malignancy Index to Discriminate Normal and Cancerous Tissue, Cancer 41: 174–182.

    Article  PubMed  CAS  Google Scholar 

  190. Tickle, C., Crawley, A. and Goodman, M. (1978) Mechanisms of Invasiveness of Epithelial Tumors: UItrastructure of the Interactions of Carcinoma Cells with Embryonic Mesenchyme and Epithelium, J. Cell Sci. 33: 133–155.

    PubMed  CAS  Google Scholar 

  191. Kluchapeva, T.E., Matveeva, V.A. and Deichman, G.I. (1978) Sensitivity of TSTA and Species-Specific Cell Membrane Antigens of Tumor Cells to Glutardehyde Treatment, Neoplasma 25: 273–278.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Biology, Northwestern University Medical School, Chicago, Illinois, USA

    Byron Anderson, Lyman E. Davis & Mario Venegas

Authors
  1. Byron Anderson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lyman E. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mario Venegas
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Texas Agricultural Experimental Station, Texas A&M University, College Station, Texas, USA

    Albert M. Wu  & L. Garry Adams  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Plenum Press, New York

About this chapter

Cite this chapter

Anderson, B., Davis, L.E., Venegas, M. (1988). Tumor-Associated Blood Group Antigen Expressions and Immunoglobulins Associated with Tumors. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4613-1663-3_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4612-8923-4

  • Online ISBN: 978-1-4613-1663-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation