Structural Comparisons of Streptococcus Pneumoniae Specific Polysaccharides of Group 9 (9N, 9V, 9L, 9A) Related to the Choice of Vaccine Components

  • James C. Richards
  • Malcolm B. Perry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 228)


Within the group 9 Streptococcus pneumoniae, four serologically cross reacting types are recognized (9A, 9L, 9N and 9V) which together are responsible for 3–4% of pneumococcal disease in North America1. Microchemical methods of glycose analysis, gas-liquid chromatography-mass spectrometry and 13C and 1H n.m.r. has permitted the complete structural elucidation of the capsular polysaccharides of the four group 9 serotypes2–6. The capsular antigens were found to be polymers of a repeating pentasaccharide unit sharing several similarities but differing in certain component glycoses and the presence of O-acetyl groups (Table).


Streptococcus Pneumoniae Pneumococcal Disease Capsular Polysaccharide Vaccine Component Minimum Energy Conformation 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • James C. Richards
    • 1
  • Malcolm B. Perry
    • 1
  1. 1.Division of Biological SciencesNational Research Council of CanadaOttawaCanada

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