Abstract
Within the group 9 Streptococcus pneumoniae, four serologically cross reacting types are recognized (9A, 9L, 9N and 9V) which together are responsible for 3–4% of pneumococcal disease in North America1. Microchemical methods of glycose analysis, gas-liquid chromatography-mass spectrometry and 13C and 1H n.m.r. has permitted the complete structural elucidation of the capsular polysaccharides of the four group 9 serotypes2–6. The capsular antigens were found to be polymers of a repeating pentasaccharide unit sharing several similarities but differing in certain component glycoses and the presence of O-acetyl groups (Table).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Szu, S.C., Lee, C.-J., Parke, C.J., Jr., Schiffman, G., Henrichsen, J., Austrian, R., Rastogi, S.C., and Robbins, J.B.b, Infect. Immun. 35, 777–782 (1982).
Bennett, L.G. and Bishop, C.T., Can. J. Chem. 58, 2724–2727, (1980).
Richards, J.C., Perry, M.B. and Kniskern, P.J., Can. J. Biochem. Cell Biol. 62, 1309–1320, (1984).
Rosell, K.-G. and Jennings, H.J., Can. J. Biochem. Cell Biol. 61, 1102–1107, (1983); Jones, C., personal communication.
Perry, M.B., Daoust, V. and Carlo, D.J., Can. J. Biochem. 59, 524–533, (1981).
Richards, J.C. and Perry, M.B., Unpublished result.
Bock, K., Pure Appl. Chem. 55, 605–622 (1983)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1988 Plenum Press, New York
About this chapter
Cite this chapter
Richards, J.C., Perry, M.B. (1988). Structural Comparisons of Streptococcus Pneumoniae Specific Polysaccharides of Group 9 (9N, 9V, 9L, 9A) Related to the Choice of Vaccine Components. In: Wu, A.M., Adams, L.G. (eds) The Molecular Immunology of Complex Carbohydrates. Advances in Experimental Medicine and Biology, vol 228. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1663-3_21
Download citation
DOI: https://doi.org/10.1007/978-1-4613-1663-3_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4612-8923-4
Online ISBN: 978-1-4613-1663-3
eBook Packages: Springer Book Archive