Structural Comparisons of Streptococcus Pneumoniae Specific Polysaccharides of Group 9 (9N, 9V, 9L, 9A) Related to the Choice of Vaccine Components
- 116 Downloads
Within the group 9 Streptococcus pneumoniae, four serologically cross reacting types are recognized (9A, 9L, 9N and 9V) which together are responsible for 3–4% of pneumococcal disease in North America1. Microchemical methods of glycose analysis, gas-liquid chromatography-mass spectrometry and 13C and 1H n.m.r. has permitted the complete structural elucidation of the capsular polysaccharides of the four group 9 serotypes2–6. The capsular antigens were found to be polymers of a repeating pentasaccharide unit sharing several similarities but differing in certain component glycoses and the presence of O-acetyl groups (Table).
KeywordsStreptococcus Pneumoniae Pneumococcal Disease Capsular Polysaccharide Vaccine Component Minimum Energy Conformation
- 6).Richards, J.C. and Perry, M.B., Unpublished result.Google Scholar