Abstract
Close apposition is a prerequisite for fusion. That apposition is determined by the interaction energies of the polar species populating the surfaces. Those energies are largely influenced by the hydration properties of the polar groups and hydration repulsion often precludes close apposition (1,2). We describe here large differences in the hydration properties of bilayers made of different phospholipid species and their mixtures; differences that greatly affect bilayer separation and may influence the facility of fusion. We have attributed some of the differences to varying contributions of an attractive hydration force (3,4). That force requires correlations between complementary polar groups on the apposing surfaces; correlations that are determined not only by the structure of the polar groups but also by the constraints imposed on them by the packing of their attached hydrocarbon chains. In another sense, hydration attraction reflects the tendency of the assembled polar groups to precipitate.
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© 1988 Plenum Press, New York
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Rand, R.P., Parsegian, V.A. (1988). The Influence of Polar Group Identity on the Interactions between Phospholipid Bilayers. In: Ohki, S., Doyle, D., Flanagan, T.D., Hui, S.W., Mayhew, E. (eds) Molecular Mechanisms of Membrane Fusion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1659-6_6
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DOI: https://doi.org/10.1007/978-1-4613-1659-6_6
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