Abstract
Many viruses infect their host cells by transfer of the genetic material contained within the viral nucleocapsid to the cytoplasm of the cell. For enveloped viruses, fusion of the viral membrane with a cellular target membrane is a key step in the transfer mechanism (White et al., 1983). Certain viruses, such as Sendai virus, fuse directly with the cellular plasma membrane and, consequently, fusion occurs at the neutral pH of the extracellular medium. Other viruses are first internalized via a process of receptor-mediated endocytosis, routing the viral particles into the endosomal compartment of the cell. The mildly acidic pH in this compartment then triggers a fusion reaction between the viral membrane and the limiting membrane of the endosomes, which also results in release of the viral nucleocapsid into the cytoplasm of the cell.
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© 1988 Plenum Press, New York
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Wilschut, J., Stegmann, T. (1988). Fusion Activity of Influenza Virus and Reconstituted Viral Envelopes: Direct Evidence for Fusion in an Intracellular Acidic Compartment. In: Ohki, S., Doyle, D., Flanagan, T.D., Hui, S.W., Mayhew, E. (eds) Molecular Mechanisms of Membrane Fusion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1659-6_32
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DOI: https://doi.org/10.1007/978-1-4613-1659-6_32
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