Abstract
Under physiologic conditions, mast cells are stimulated to secrete (“degranulate”) when a multivalent antigen simultaneously binds two or more IgE antibodies that, in turn, are bound to IgE receptors in the mast cell membrane. The antigen-antibody binding apparently brings IgE-receptors into close proximity so that they form dimers or oligomers. Since the IgE receptor is a membrane-spanning protein, this oligomerization communicates itself to the cytoplasmic face of the membrane, and thereby initiates a chain of events that ultimately leads to degranulation (Ishizaka & Ishizaka, 1984). Any maneuver leading to oligomerization or clustering of IgE receptors induces degranulation. Probably the first effect of IgE-receptor oligomerization is to activate a phospholipase-C, probably via GTP binding to a G-protein (Gomperts, 1986).
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© 1988 Plenum Press, New York
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Almers, W., Breckenridge, L.J. (1988). Early Steps in the Exocytosis of Secretory Vesicles in Mast Cells. In: Ohki, S., Doyle, D., Flanagan, T.D., Hui, S.W., Mayhew, E. (eds) Molecular Mechanisms of Membrane Fusion. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1659-6_15
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DOI: https://doi.org/10.1007/978-1-4613-1659-6_15
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