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Microfilament Involvement in Hirano Body Formation

  • Chapter
Alterations in the Neuronal Cytoskeleton in Alzheimer Disease

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 34))

Abstract

The neuron, like many other types of cells, contains three major morphologically distinct filamentous systems: microfilaments, intermediate filaments and microtubules.1 The role of these cytoskeletal components in the neuron has been unclear until recently. These discoveries have implicated the cytoskeleton in many cell functions, including internal organization.2–5 Microfilaments in neurons have mainly been studied in relation to axonal transport.6–9 By light microscopy, actin filaments have been demonstrated in neurites,10–13 growth cones of avian dorsal root ganglia cells14–18 and in microspikes of murine neuroblastoma cells.10–11 In situ organization of actin filaments in dendritic spines, dendrites and axon terminals has been demonstrated19 using heavy meromyosin decoration.20

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  1. Case Western Reserve University, Cleveland, Ohio, USA

    Pamela G. Galloway & George Perry

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    George Perry

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Galloway, P.G., Perry, G. (1987). Microfilament Involvement in Hirano Body Formation. In: Perry, G. (eds) Alterations in the Neuronal Cytoskeleton in Alzheimer Disease. Advances in Behavioral Biology, vol 34. Springer, Boston, MA. https://doi.org/10.1007/978-1-4613-1657-2_15

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